Search Results - "Wolthers, Katja C"

World-Wide Prevalence and Genotype Distribution of Enteroviruses by Brouwer, Lieke, Moreni, Giulia, Wolthers, Katja C, Pajkrt, Dasja

“…Enteroviruses (EVs) are highly prevalent viruses world-wide, causing a wide range of diseases in both children and adults. Insight in the global prevalence of…”
Get full text

Neurotropic virus infections as the cause of immediate and delayed neuropathology by Ludlow, Martin, Kortekaas, Jeroen, Herden, Christiane, Hoffmann, Bernd, Tappe, Dennis, Trebst, Corinna, Griffin, Diane E., Brindle, Hannah E., Solomon, Tom, Brown, Alan S., van Riel, Debby, Wolthers, Katja C., Pajkrt, Dasja, Wohlsein, Peter, Martina, Byron E. E., Baumgärtner, Wolfgang, Verjans, Georges M., Osterhaus, Albert D. M. E.

“…A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and…”
Get full text

A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine by Roodsant, Thomas, Navis, Marit, Aknouch, Ikrame, Renes, Ingrid B, van Elburg, Ruurd M, Pajkrt, Dasja, Wolthers, Katja C, Schultsz, Constance, van der Ark, Kees C H, Sridhar, Adithya, Muncan, Vanesa

“…Gut organoids are stem cell derived 3D models of the intestinal epithelium that are useful for studying interactions between enteric pathogens and their host…”
Get full text

Parechovirus A Pathogenesis and the Enigma of Genotype A-3 by Sridhar, Adithya, Karelehto, Eveliina, Brouwer, Lieke, Pajkrt, Dasja, Wolthers, Katja C

“…is a species in the genus within the family that can cause severe disease in children. Relatively little is known on epidemiology and pathogenesis. This review…”
Get full text

Apical-out airway organoids as a platform for studying viral infections and screening for antiviral drugs by Stroulios, Georgios, Brown, Tyler, Moreni, Giulia, Kondro, Douglas, Dei, Alessandro, Eaves, Allen, Louis, Sharon, Hou, Juan, Chang, Wing, Pajkrt, Dasja, Wolthers, Katja C., Sridhar, Adithya, Simmini, Salvatore

“…Airway organoids are polarized 3D epithelial structures that recapitulate the organization and many of the key functions of the in vivo tissue. They present an…”
Get full text

Transmission of Zika virus by dendritic cell subsets in skin and vaginal mucosa by Eder, Julia, Zijlstra-Willems, Esther, Koen, Gerrit, Kootstra, Neeltje A, Wolthers, Katja C, Geijtenbeek, Teunis B

“…Zika virus is a member of the Flaviviridae family that has caused recent outbreaks associated with neurological malformations. Transmission of Zika virus…”
Get full text

Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection by García-Rodríguez, Inés, Sridhar, Adithya, Pajkrt, Dasja, Wolthers, Katja C

“…The knowledge about enteric viral infection has vastly increased over the last eight years due to the development of intestinal organoids and enteroids that…”
Get full text

Amino acid variation at VP1-145 of enterovirus A71 determines the viral infectivity and receptor usage in a primary human intestinal model by Aknouch, Ikrame, García-Rodríguez, Inés, Giugliano, Francesca Paola, Calitz, Carlemi, Koen, Gerrit, van Eijk, Hetty, Johannessson, Nina, Rebers, Sjoerd, Brouwer, Lieke, Muncan, Vanesa, Stittelaar, Koert J, Pajkrt, Dasja, Wolthers, Katja C, Sridhar, Adithya

“…Enterovirus A71 (EV-A71) can elicit a wide variety of human diseases such as hand, foot, and mouth disease and severe or fatal neurological complications. It…”
Get full text

Replication and Inhibitors of Enteroviruses and Parechoviruses by van der Linden, Lonneke, Wolthers, Katja C, van Kuppeveld, Frank J M

“…The Enterovirus (EV) and Parechovirus genera of the picornavirus family include many important human pathogens, including poliovirus, rhinovirus, EV-A71,…”
Get full text

Parechovirus A prevalence in adults in The Netherlands by Brouwer, Lieke, Wolthers, Katja C., Pajkrt, Dasja

“…Human parechoviruses (HPeV) of the species Parechovirus A are highly prevalent disease-causing pathogens in children worldwide. HPeVs are capable of causing…”
Get full text

Human Brain Organoids as Models for Central Nervous System Viral Infection by Depla, Josse A, Mulder, Lance A, de Sá, Renata Vieira, Wartel, Morgane, Sridhar, Adithya, Evers, Melvin M, Wolthers, Katja C, Pajkrt, Dasja

“…Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood, and this is partly due to the limitations of currently used…”
Get full text

Parechoviruses in children: understanding a new infection by Harvala, Heli, Wolthers, Katja C, Simmonds, Peter

“…PURPOSE OF REVIEWHuman parechoviruses (HPeVs) within the large and growing family of Picornaviridae are common human pathogens associated with a wide spectrum…”
Get full text

Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe by Benschop, Kimberley S M, Broberg, Eeva K, Hodcroft, Emma, Schmitz, Dennis, Albert, Jan, Baicus, Anda, Bailly, Jean-Luc, Baldvinsdottir, Gudrun, Berginc, Natasa, Blomqvist, Soile, Böttcher, Sindy, Brytting, Mia, Bujaki, Erika, Cabrerizo, Maria, Celma, Cristina, Cinek, Ondrej, Claas, Eric C J, Cremer, Jeroen, Dean, Jonathan, Dembinski, Jennifer L, Demchyshyna, Iryna, Diedrich, Sabine, Dudman, Susanne, Dunning, Jake, Dyrdak, Robert, Emmanouil, Mary, Farkas, Agnes, De Gascun, Cillian, Fournier, Guillaume, Georgieva, Irina, Gonzalez-Sanz, Ruben, van Hooydonk-Elving, Jolanda, Jääskeläinen, Anne J, Jancauskaite, Ruta, Keeren, Kathrin, Fischer, Thea K, Krokstad, Sidsel, Nikolaeva-Glomb, Lubomira, Novakova, Ludmila, Midgley, Sofie E, Mirand, Audrey, Molenkamp, Richard, Morley, Ursula, Mossong, Joël, Muralyte, Svajune, Murk, Jean-Luc, Nguyen, Trung, Nordbø, Svein A, Österback, Riikka, Pas, Suzan, Pellegrinelli, Laura, Pogka, Vassiliki, Prochazka, Birgit, Rainetova, Petra, Van Ranst, Marc, Roorda, Lieuwe, Schuffenecker, Isabelle, Schuurman, Rob, Stoyanova, Asya, Templeton, Kate, Verweij, Jaco J, Voulgari-Kokota, Androniki, Vuorinen, Tytti, Wollants, Elke, Wolthers, Katja C, Zakikhany, Katherina, Neher, Richard, Harvala, Heli, Simmonds, Peter

“…In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30…”
Get full text

Successful IVIG treatment of human parechovirus-associated dilated cardiomyopathy in an infant by Wildenbeest, Joanne G, Wolthers, Katja C, Straver, Bart, Pajkrt, Dasja

“…Human parechoviruses (HPeVs) are closely related to human enteroviruses and exhibit many similarities in disease spectrum and symptoms. HPeV1 is most commonly…”
Get full text

Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease by Capendale, Pamela E., García-Rodríguez, Inés, Ambikan, Anoop T., Mulder, Lance A., Depla, Josse A., Freeze, Eline, Koen, Gerrit, Calitz, Carlemi, Sood, Vikas, Vieira de Sá, Renata, Neogi, Ujjwal, Pajkrt, Dasja, Sridhar, Adithya, Wolthers, Katja C.

“…Picornaviruses are a leading cause of central nervous system (CNS) infections. While genotypes such as parechovirus A3 (PeV-A3) and echovirus 11 (E11) can…”
Get full text

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3 by García-Rodríguez, Inés, van Eijk, Hetty, Koen, Gerrit, Pajkrt, Dasja, Sridhar, Adithya, Wolthers, Katja C

“…Human parechovirus (PeV-A), one of the species within the family, is known to cause disease in humans. The most commonly detected genotypes are PeV-A1,…”
Get full text

Seroepidemiology of Parechovirus A3 Neutralizing Antibodies, Australia, the Netherlands, and United States by Karelehto, Eveliina, Brouwer, Lieke, Benschop, Kimberley, Kok, Jen, Basile, Kerri, McMullan, Brendan, Rawlinson, William, Druce, Julian, Nicholson, Suellen, Selvarangan, Rangaraj, Harrison, Christopher, Lankachandra, Kamani, van Eijk, Hetty, Koen, Gerrit, de Jong, Menno, Pajkrt, Dasja, Wolthers, Katja C

“…Recent parechovirus A3 (PeV-A3) outbreaks in Australia suggest lower population immunity compared with regions that have endemic PeV-A3 circulation. A…”
Get full text

Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis by Shakeel, Shabih, Westerhuis, Brenda M., Domanska, Ausra, Koning, Roman I., Matadeen, Rishi, Koster, Abraham J., Bakker, Arjen Q., Beaumont, Tim, Wolthers, Katja C., Butcher, Sarah J.

“…The poorly studied picornavirus, human parechovirus 3 (HPeV3) causes neonatal sepsis with no therapies available. Our 4.3-Å resolution structure of HPeV3 on…”
Get full text

Evaluation of 3D Human Intestinal Organoids as a Platform for EV-A71 Antiviral Drug Discovery by Masmoudi, Fatma, Santos-Ferreira, Nanci, Pajkrt, Dasja, Wolthers, Katja C, DeGroot, Jeroen, Vlaming, Maria L H, Rocha-Pereira, Joana, Buti, Ludovico

“…Enteroviruses are a leading cause of upper respiratory tract, gastrointestinal, and neurological infections. Management of enterovirus-related diseases has…”
Get full text

Human Parechoviruses as an Important Viral Cause of Sepsislike Illness and Meningitis in Young Children by Wolthers, Katja C., Benschop, Kimberley S. M., Schinkel, Janke, Molenkamp, Richard, Bergevoet, Rosemarijn M., Spijkerman, Ingrid J. B., Kraakman, H. Carlijn, Pajkrt, Dasja

“…Background. Enteroviruses (EVs) belong to the family Picornaviridae and are a well-known cause of neonatal sepsis and viral meningitis. Human parechoviruses…”
Get full text