Search Results - "Wolthers, B O"

Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol by Wolthers, B O, Frandsen, T L, Abrahamsson, J, Albertsen, B K, Helt, L R, Heyman, M, Jónsson, Ó G, Kõrgvee, L T, Lund, B, Raja, R A, Rasmussen, K K, Taskinen, M, Tulstrup, M, Vaitkevičienė, G E, Yadav, R, Gupta, R, Schmiegelow, K

“…Asparaginase (ASP)-associated pancreatitis (AAP) occurs during acute lymphoblastic leukemia treatment. Among 1285 children (1.0–17.9 years) diagnosed during…”
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Intermittent Versus Continuous PEG-Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study by Albertsen, Birgitte Klug, Grell, Kathrine, Abrahamsson, Jonas, Lund, Bendik, Vettenranta, Kim, Jónsson, Ólafur G, Frandsen, Thomas L, Wolthers, Benjamin O, Heyman, Mats, Schmiegelow, Kjeld

“…Asparaginase is an essential drug in childhood acute lymphoblastic leukemia (ALL) therapy and is frequently given for months to obtain continuous asparagine…”
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Acute liver failure in a four-year old girl during maintenance therapy of acute lymphoblastic leukemia by Raja, R. A., Wolthers, B. O., Frandsen, T. L., Albertsen, B. K., Schulz, N., Damholt, M. B., Schmiegelow, K., Jørgensen, M. H.

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Effects of germ line DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia by Tulstrup, M., Moriyama, T., Jiang, C., Grosjean, M., Nersting, J., Abrahamsson, Jonas, Grell, K., Hjalgrim, L. L., Jonsson, O. G., Kanerva, J., Lund, B., Nielsen, S. N., Nielsen, R. L., Quist-Paulsen, P., Pruunsild, K., Wolthers, B. O., Zhang, H., Gupta, R., Yang, J. J., Schmiegelow, K.

“…Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment…”
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NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia by Tulstrup, Morten, Grosjean, Marie, Nielsen, Stine Nygaard, Grell, Kathrine, Wolthers, Benjamin Ole, Wegener, Peder Skov, Jonsson, Olafur Gisli, Lund, Bendik, Harila-Saari, Arja, Abrahamsson, Jonas, Vaitkeviciene, Goda, Pruunsild, Kaie, Toft, Nina, Holm, Mette, Hulegårdh, Erik, Liestøl, Sigurd, Griskevicius, Laimonas, Punab, Mari, Wang, Jinhua, Carroll, William L., Zhang, Zeyu, Dalgaard, Marlene D., Gupta, Ramneek, Nersting, Jacob, Schmiegelow, Kjeld

“…The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a…”
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Relapse risk following truncation of pegylated asparaginase in childhood acute lymphoblastic leukemia by Gottschalk Højfeldt, Sofie, Grell, Kathrine, Abrahamsson, Jonas, Lund, Bendik, Vettenranta, Kim, Jónsson, Ólafur G., Frandsen, Thomas L., Wolthers, Benjamin O., Marquart, Hanne Vibeke, Vaitkeviciene, Goda, Lepik, Kristi, Heyman, Mats, Schmiegelow, Kjeld, Albertsen, Birgitte Klug

“…Truncation of asparaginase treatment due to asparaginase-related toxicities or silent inactivation (SI) is common and may increase relapse risk in acute…”
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Genetic predisposition to PEG‐asparaginase hypersensitivity in children treated according to NOPHO ALL2008 by Højfeldt, Sofie G., Wolthers, Benjamin O., Tulstrup, Morten, Abrahamsson, Jonas, Gupta, Ramneek, Harila‐Saari, Arja, Heyman, Mats, Henriksen, Louise T., Jónsson, Òlafur G., Lähteenmäki, Päivi M., Lund, Bendik, Pruunsild, Kaie, Vaitkeviciene, Goda, Schmiegelow, Kjeld, Albertsen, Birgitte K.

“…Summary Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypersensitivity reactions to pegylated asparaginase…”
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The Association between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in the NOPHO ALL2008 Protocol by Lynggaard, Line Stensig, Moeller, Lisbeth, Rank, Cecilie Utke, Gottschalk Højfeldt, Sofie, Henriksen, Louise Tram, Jarvis, Kirsten Brunsvig, Ranta, Susanna, Niinimäki, Riitta, Harila-Saari, Arja, Wolthers, Benjamin Ole, Heyman, Mats, Frandsen, Thomas Leth, Schmiegelow, Kjeld, Albertsen, Birgitte Klug

“…▪ Introduction: Asparaginase is a key component in the treatment of childhood acute lymphoblastic leukemia (ALL), but the treatment is jeopardized by 20% or…”
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Insulin‐dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia by Wolthers, Benjamin Ole, Mogensen, Pernille R., Frandsen, Thomas L., Abrahamsson, Jonas, Behrendtz, Mikael, Heyman, Mats, Lohi, Olli, Norén‐Nyström, Ulrika, Ruud, Ellen, Schmiegelow, Kjeld

“…Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by…”
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Intermittent Vs Continuous Asparaginase to Reduce Asparaginase-Associated Toxicities: A NOPHO ALL2008 Randomized Study by Albertsen, Birgitte Klug, Abrahamsson, Jonas, Lund, Bendik, Vettenranta, Kim, Jónsson, Ólafur G., Frandsen, Thomas Leth, Wolthers, Benjamin Ole, Grell, Kathrine, Heyman, Mats, Schmiegelow, Kjeld

“…▪ Introduction: Asparaginase is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL), but it also causes a range of toxicities of which several…”
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Genetic Variants in the HLA-genes Are Associated with PEG-asparaginase Allergy - a Genome Wide Association Study on the NOPHO ALL2008 Protocol by Gottschalk Højfeldt, Sofie, Wolthers, Benjamin Ole, Harila-Saari, Arja, Lähteenmäki, Päivi, Lund, Bendik, Abrahamsson, Jonas, Tulstrup, Morten, Henriksen, Louise Tram, Vaitkeviciene, Goda, Pruunsild, Kaie, Jonsson, Olafur G., Heyman, Mats, Schmiegelow, Kjeld, Albertsen, Birgitte Klug

“…Introduction: Asparaginase is a cornerstone in treatment of childhood acute lymphoblastic leukemia (ALL). However, balancing positive anti-leukemic effect…”
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Asparaginase-Associated Pancreatitis in ALL: Results from the NOPHO ALL2008 Treatment of Patients 1-45 Years by Rank, Cecilie Utke, Wolthers, Benjamin Ole, Grell, Kathrine, Albertsen, Birgitte Klug, Frandsen, Thomas Leth, Overgaard, Ulrik Malthe, Toft, Nina, Nielsen, Ove Juul, Wehner, Peder Skov, Harila-Saari, Arja, Heyman, Mats, Abrahamsson, Jonas, Norén-Nyström, Ulrika, Tomaszewska-Toporska, Beata, Lund, Bendik, Jarvis, Kirsten Brunsvig, Quist-Paulsen, Petter, Vaitkeviciene, Goda Elizabeta, Griškevičius, Laimonas, Taskinen, Mervi, Wartiovaara-Kautto, Ulla, Lepik, Kristi, Punab, Mari, Jónsson, Ólafur Gísli, Schmiegelow, Kjeld

“…Premature discontinuation of asparaginase reduces cure rate in contemporary acute lymphoblastic leukemia (ALL) treatment. One of the commonest causes of…”
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Asparaginase enzyme activity levels and toxicity in childhood acute lymphoblastic leukemia: a NOPHO ALL2008 study by Lynggaard, Line Stensig, Rank, Cecilie Utke, Hansen, Stefan Nygaard, Gottschalk Højfeldt, Sofie, Henriksen, Louise Tram, Jarvis, Kirsten Brunsvig, Ranta, Susanna, Niinimäki, Riitta, Harila-Saari, Arja, Wolthers, Benjamin O, Frandsen, Thomas L., Heyman, Mats, Schmiegelow, Kjeld, Albertsen, Birgitte Klug

“…Asparaginase treatment is a mainstay in contemporary treatment of acute lymphoblastic leukemia (ALL), but substantial asparaginase-related toxicity may lead to…”
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Pharmacogenetics of the Central Nervous System—Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia by Sági, Judit C., Gézsi, András, Egyed, Bálint, Jakab, Zsuzsanna, Benedek, Noémi, Attarbaschi, Andishe, Köhrer, Stefan, Sipek, Jakub, Winkowska, Lucie, Zaliova, Marketa, Anastasopoulou, Stavroula, Wolthers, Benjamin Ole, Ranta, Susanna, Szalai, Csaba, Kovács, Gábor T., Semsei, Ágnes F., Erdélyi, Dániel J.

“…Despite improving cure rates in childhood acute lymphoblastic leukemia (ALL), therapeutic side effects and relapse are ongoing challenges. These can also…”
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Acute liver failure in a four-year old girl during maintenance therapy of acute lymphoblastic leukemia by Raja, R A, Wolthers, B O, Frandsen, T L, Albertsen, B K, Schulz, N, Damholt, M B, Schmiegelow, K, Jørgensen, M H

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