Search Results - "Wolstenholme, Jennifer T."

Ethanol-Induced Behavioral Sensitization Alters the Synaptic Transcriptome and Exon Utilization in DBA/2J Mice by O'Brien, Megan A, Weston, Rory M, Sheth, Nihar U, Bradley, Steven, Bigbee, John, Pandey, Ashutosh, Williams, Robert W, Wolstenholme, Jennifer T, Miles, Michael F

“…Alcoholism is a complex behavioral disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior…”
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The role of Bisphenol A in shaping the brain, epigenome and behavior by Wolstenholme, Jennifer T., Rissman, Emilie F., Connelly, Jessica J.

“…Bisphenol A (BPA) is a xenoestrogen that was first synthesized in 1891. Its estrogenic properties were discovered in 1930, and shortly after that chemists…”
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Transgenerational effects of prenatal bisphenol A on social recognition by Wolstenholme, Jennifer T., Goldsby, Jessica A., Rissman, Emilie F.

“…Bisphenol A (BPA) is a man-made endocrine disrupting compound used to manufacture polycarbonate plastics. It is found in plastic bottles, canned food linings,…”
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Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice by de la Fuente Revenga, Mario, Zhu, Bohan, Guevara, Christopher A., Naler, Lynette B., Saunders, Justin M., Zhou, Zirui, Toneatti, Rudy, Sierra, Salvador, Wolstenholme, Jennifer T., Beardsley, Patrick M., Huntley, George W., Lu, Chang, González-Maeso, Javier

“…Clinical evidence suggests that rapid and sustained antidepressant action can be attained with a single exposure to psychedelics. However, the biological…”
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Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression by Wolstenholme, Jennifer T, Edwards, Michelle, Shetty, Savera R. J, Gatewood, Jessica D, Taylor, Julia A, Rissman, Emilie F, Connelly, Jessica J

“…Bisphenol A (BPA) is a plasticizer and an endocrine-disrupting chemical. It is present in a variety of products used daily including food containers, paper,…”
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Gestational exposure to low dose bisphenol A alters social behavior in juvenile mice by Wolstenholme, Jennifer T, Taylor, Julia A, Shetty, Savera R J, Edwards, Michelle, Connelly, Jessica J, Rissman, Emilie F

“…Bisphenol A (BPA) is a man-made compound used to make polycarbonate plastics and epoxy resins; public health concerns have been fueled by findings that BPA…”
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Areas of Convergence and Divergence in Adolescent Social Isolation and Binge Drinking: A Review by Lodha, Jyoti, Brocato, Emily, Wolstenholme, Jennifer T

“…Adolescence is a critical developmental period characterized by enhanced social interactions, ongoing development of the frontal cortex and maturation of…”
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Bisphenol a Exposure in Utero Disrupts Hypothalamic Gene Expression Particularly Genes Suspected in Autism Spectrum Disorders and Neuron and Hormone Signaling by Henriksen, Anne D, Andrade, Alejandro, Harris, Erin P, Rissman, Emilie F, Wolstenholme, Jennifer T

“…Bisphenol A (BPA) is an endocrine-disrupting compound detected in the urine of more than 92% of humans, easily crosses the placental barrier, and has been…”
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Adolescent binge ethanol impacts H3K36me3 regulation of synaptic genes by Brocato, Emily R, Wolstenholme, Jennifer T

“…Adolescence is marked in part by the ongoing development of the prefrontal cortex (PFC). Binge ethanol use during this critical stage in neurodevelopment…”
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Chronic clozapine treatment restrains via HDAC2 the performance of mGlu2 receptor agonism in a rodent model of antipsychotic activity by de la Fuente Revenga, Mario, Ibi, Daisuke, Cuddy, Travis, Toneatti, Rudy, Kurita, Mitsumasa, Ijaz, Maryum K, Miles, Michael F, Wolstenholme, Jennifer T, González-Maeso, Javier

“…Preclinical findings in rodent models pointed toward activation of metabotropic glutamate 2/3 (mGlu2/3) receptors as a new pharmacological approach to treat…”
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Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice by Wolstenholme, Jennifer T., Saunders, Justin M., Smith, Maren, Kang, Jason D., Hylemon, Phillip B., González-Maeso, Javier, Fagan, Andrew, Zhao, Derrick, Sikaroodi, Masoumeh, Herzog, Jeremy, Shamsaddini, Amirhossein, Peña-Rodríguez, Marcela, Su, Lianyong, Tai, Yun-Ling, Zheng, Jing, Cheng, Po-Cheng, Sartor, R. Balfour, Gillevet, Patrick M., Zhou, Huiping, Bajaj, Jasmohan S.

“…Alcohol use disorder is a major cause of morbidity, which requires newer treatment approaches. We previously showed in a randomized clinical trial that alcohol…”
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Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development by Brocato, Emily R, Easter, Rachel, Morgan, Alanna, Kakani, Meenakshi, Lee, Grace, Wolstenholme, Jennifer T

“…Binge drinking in adolescence can disrupt myelination and cause brain structural changes that persist into adulthood. Alcohol consumption at a younger age…”
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Intermittent Ethanol during Adolescence Leads to Lasting Behavioral Changes in Adulthood and Alters Gene Expression and Histone Methylation in the PFC by Wolstenholme, Jennifer T, Mahmood, Tariq, Harris, Guy M, Abbas, Shahroze, Miles, Michael F

“…Adolescents primarily consume alcohol in binges, which can be particularly harmful to the developing frontal cortex and increase risk for an adult alcohol use…”
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Genomic analysis of individual differences in ethanol drinking: evidence for non-genetic factors in C57BL/6 mice by Wolstenholme, Jennifer T, Warner, Jon A, Capparuccini, Maria I, Archer, Kellie J, Shelton, Keith L, Miles, Michael F

“…Genetic analysis of factors affecting risk to develop excessive ethanol drinking has been extensively studied in humans and animal models for over 20 years…”
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Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice by Hideshima, Kelsey S., Hojati, Ashkhan, Saunders, Justin M., On, Doan M., de la Fuente Revenga, Mario, Shin, Jong M., Sánchez-González, Ana, Dunn, Cassandra M., Pais, Alexander B., Pais, Anthony C., Miles, Michael F., Wolstenholme, Jennifer T., González-Maeso, Javier

“…Background Serotonin 5-HT 2A and metabotropic glutamate 2 (mGlu2) are neurotransmitter G protein-coupled receptors (GPCRs) involved in the signaling mechanisms…”
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Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice by Dawson, Anton, Wolstenholme, Jennifer T., Roni, Monzurul A., Campbell, Vera C., Jackson, Asti, Slater, Cassandra, Bagdas, Deniz, Perez, Erika E., Bettinger, Jill C., De Biasi, Mariella, Miles, Michael F., Damaj, M. Imad

“…Evidence suggests that there is an association between polymorphisms in the α5 nicotinic acetylcholine receptor (nAChR) subunit and risk of developing alcohol…”
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The Allostatic Impact of Chronic Ethanol on Gene Expression: A Genetic Analysis of Chronic Intermittent Ethanol Treatment in the BXD Cohort by van der Vaart, Andrew D, Wolstenholme, Jennifer T., Ph.D, Smith, Maren, Harris, Guy, Lopez, Marcelo F, Wolen, Aaron R, Becker, Howard C, Williams, Robert W, Miles, Michael F

“…Abstract The transition from acute to chronic ethanol exposure leads to lasting behavioral and physiological changes such as increased consumption, dependence,…”
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A Novel Neighbor Housing Environment Enhances Social Interaction and Rescues Cognitive Deficits from Social Isolation in Adolescence by Pais, Alexander B, Pais, Anthony C, Elmisurati, Gabriel, Park, So Hyun, Miles, Michael F, Wolstenholme, Jennifer T

“…Adolescence is characterized by high levels of playful social interaction, cognitive development, and increased risk-taking behavior. Juvenile exposure to…”
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Comparing behavior following binge ethanol in adolescent and adult DBA/2 J mice by Bent, Maria Alexis M., Pais, A. Christian, Wolstenholme, Jennifer T.

“…The adolescent brain undergoes maturation in areas critically involved in reward, addiction, and memory. Adolescents consume alcohol more than any other drug,…”
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Multi- and transgenerational consequences of Bisphenol A on sexually dimorphic cell populations in mouse brain by Goldsby, Jessica A, Wolstenholme, Jennifer T, Rissman, Emilie F

“…Bisphenol-A (BPA) is an endocrine disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts and many…”
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