Search Results - "Wolstenholme, Adrian J."

Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species by Blanchard, Alexandra, Guégnard, Fabrice, Charvet, Claude L, Crisford, Anna, Courtot, Elise, Sauvé, Christine, Harmache, Abdallah, Duguet, Thomas, O'Connor, Vincent, Castagnone-Sereno, Philippe, Reaves, Barbara, Wolstenholme, Adrian J, Beech, Robin N, Holden-Dye, Lindy, Neveu, Cedric

“…Cholinergic agonists such as levamisole and pyrantel are widely used as anthelmintics to treat parasitic nematode infestations. These drugs elicit spastic…”
Get full text

Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions by Kotze, Andrew C., Hunt, Peter W., Skuce, Philip, von Samson-Himmelstjerna, Georg, Martin, Richard J., Sager, Heinz, Krücken, Jürgen, Hodgkinson, Jane, Lespine, Anne, Jex, Aaron R., Gilleard, John S., Beech, Robin N., Wolstenholme, Adrian J., Demeler, Janina, Robertson, Alan P., Charvet, Claude L., Neveu, Cedric, Kaminsky, Ronald, Rufener, Lucien, Alberich, Melanie, Menez, Cecile, Prichard, Roger K.

“…•We report on the Consortium for Anthelmintic Resistance and Susceptibility 2013 meeting.•Recent advances in the identification of markers for anthelmintic…”
Get full text

Lack of detectable short-term effects of a single dose of ivermectin on the human immune system by Wilson, Natalie E, Reaves, Barbara J, Wolstenholme, Adrian J

“…Abstract Background Ivermectin is widely used in human and animal medicine to treat and prevent parasite nematode infections. It has been suggested that its…”
Get full text

Glutamate-gated Chloride Channels by Wolstenholme, Adrian J.

“…Glutamate-gated chloride channels (GluCls) are found only in protostome invertebrate phyla but are closely related to mammalian glycine receptors. They have a…”
Get full text

An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus by McCavera, Samantha, Rogers, Adrian T, Yates, Darran M, Woods, Debra J, Wolstenholme, Adrian J

“…Nematode glutamate-gated chloride channels are targets of the macrocyclic lactones, the most important group of anthelmintics available. In Xenopus laevis…”
Get more information

Refugia and anthelmintic resistance: Concepts and challenges by Hodgkinson, Jane E., Kaplan, Ray M., Kenyon, Fiona, Morgan, Eric R., Park, Andrew W., Paterson, Steve, Babayan, Simon A., Beesley, Nicola J., Britton, Collette, Chaudhry, Umer, Doyle, Stephen R., Ezenwa, Vanessa O., Fenton, Andy, Howell, Sue B., Laing, Roz, Mable, Barbara K., Matthews, Louise, McIntyre, Jennifer, Milne, Catherine E., Morrison, Thomas A., Prentice, Jamie C., Sargison, Neil D., Williams, Diana J.L., Wolstenholme, Adrian J., Devaney, Eileen

“…Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management…”
Get full text

Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes by Courtot, Elise, Charvet, Claude L, Beech, Robin N, Harmache, Abdallah, Wolstenholme, Adrian J, Holden-Dye, Lindy, O'Connor, Vincent, Peineau, Nicolas, Woods, Debra J, Neveu, Cedric

“…Acetylcholine receptors are pentameric ligand-gated channels involved in excitatory neuro-transmission in both vertebrates and invertebrates. In nematodes,…”
Get full text

Resistance to macrocyclic lactones by Wolstenholme, Adrian J, Kaplan, Ray M

“…Resistance to the macrocyclic lactones (MLs) has been confirmed or suspected in many target organisms and is a serious problem in some. For some species, such…”
Get more information

Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus by Williamson, Sally M., Storey, Bob, Howell, Sue, Harper, Kate M., Kaplan, Ray M., Wolstenholme, Adrian J.

“…[Display omitted] ► We compared candidate resistance gene expression in two US isolates of Haemonchus contortus. ► UGA/2004 was resistant to all three drug…”
Get full text

EAT-18 is an essential auxiliary protein interacting with the non-alpha nAChR subunit EAT-2 to form a functional receptor by Choudhary, Shivani, Buxton, Samuel K, Puttachary, Sreekanth, Verma, Saurabh, Mair, Gunnar R, McCoy, Ciaran J, Reaves, Barbara J, Wolstenholme, Adrian J, Martin, Richard J, Robertson, Alan P

“…Nematode parasites infect approximately 1.5 billion people globally and are a significant public health concern. There is an accepted need for new, more…”
Get full text

Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol by Savadelis, Molly D, Day, Katherine M, Bradner, Jenna L, Wolstenholme, Adrian J, Dzimianski, Michael T, Moorhead, Andrew R

“…The American Heartworm Society currently recommends the use of a monthly macrocyclic lactone, a 28-day course of 10 mg/kg doxycycline BID, and the 3-dose…”
Get full text

FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways by Feng, Ying, Williams, Barnabas G, Koumanov, Françoise, Wolstenholme, Adrian J, Holman, Geoffrey D

“…Caenorhabditis elegans is widely used as a model for investigation of the relationships between aging, nutrient restriction and signalling via the DAF-2…”
Get more information

Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release by McCoy, Ciaran J, Reaves, Barbara J, Giguère, Steeve, Coates, Ruby, Rada, Balázs, Wolstenholme, Adrian J

“…Wuchereria bancrofti, Brugia malayi and Brugia timori infect over 100 million people worldwide and are the causative agents of lymphatic filariasis. Some…”
Get full text

Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones? by Maclean, Mary J, Savadelis, Molly D, Coates, Ruby, Dzimianski, Michael T, Jones, Corey, Benbow, Cynthia, Storey, Bobby E, Kaplan, Ray M, Moorhead, Andrew R, Wolstenholme, Adrian J

“…Several reports have confirmed that macrocyclic lactone-resistant isolates of Dirofilaria immitis are circulating in the United States; however, the prevalence…”
Get full text

Surviving in a Toxic World by Wolstenholme, Adrian J.

“…Natural variations in a single gene of wild C. elegans populations confer resistance to the bacterial toxin avermectin. The world can be a dangerous place…”
Get full text

Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans by Glendinning, Susan K, Buckingham, Steven D, Sattelle, David B, Wonnacott, Susan, Wolstenholme, Adrian J

“…Anthelmintic resistance is a major problem in livestock farming, especially of small ruminants, but our understanding of it has been limited by the difficulty…”
Get full text

Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro by Vatta, Adriano F, Dzimianski, Michael, Storey, Bob E, Camus, Melinda S, Moorhead, Andrew R, Kaplan, Ray M, Wolstenholme, Adrian J

“…The macrocyclic lactones are the only anthelmintics used to prevent heartworm disease, but it is very difficult to reproduce their in vivo efficacy against…”
Get full text

Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite by Berrafato, Tessa, Coates, Ruby, Reaves, Barbara J., Kulke, Daniel, Wolstenholme, Adrian J.

“…The macrocyclic lactone anthelmintics are the only class of drug currently used to prevent heartworm disease. Their extremely high potency in vivo is not…”
Get full text

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside by Hübner, Marc P., Townson, Simon, Gokool, Suzanne, Tagboto, Senyo, Maclean, Mary J., Verocai, Guilherme G., Wolstenholme, Adrian J., Frohberger, Stefan J., Hoerauf, Achim, Specht, Sabine, Scandale, Ivan, Harder, Achim, Glenschek-Sieberth, Martin, Hahnel, Steffen R., Kulke, Daniel

“…Filariae are vector-borne nematodes responsible for an enormous burden of disease. Human lymphatic filariasis, caused by Wuchereria bancrofti, Brugia malayi,…”
Get full text

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits by Williamson, Sally M, Robertson, Alan P, Brown, Laurence, Williams, Tracey, Woods, Debra J, Martin, Richard J, Sattelle, David B, Wolstenholme, Adrian J

“…Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite…”
Get full text