Search Results - "Wolstenholme, A."

Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics by Wolstenholme, A J, Rogers, A T

“…The macrocyclic lactones are the biggest selling and arguably most effective anthelmintics currently available. They are good substrates for the…”
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Molecular detection of benzimidazole resistance in Haemonchus contortus using real-time PCR and pyrosequencing by von Samson-Himmelstjerna, G, Walsh, T K, Donnan, A A, Carrière, S, Jackson, F, Skuce, P J, Rohn, K, Wolstenholme, A J

“…Benzimidazoles (BZ) are widely used to treat parasitic nematode infections of humans and animals, but resistance is widespread in veterinary parasites. Several…”
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Assertive outreach treatment versus care as usual for the treatment of high-need, high-cost alcohol related frequent attenders: study protocol for a randomised controlled trial by Blackwood, R, Wolstenholme, A, Kimergård, A, Fincham-Campbell, S, Khadjesari, Z, Coulton, S, Byford, S, Deluca, P, Jennings, S, Currell, E, Dunne, J, O'Toole, J, Winnington, J, Finch, E, Drummond, C

“…Alcohol-related hospital admissions have doubled in the last ten years to > 1.2 m per year in England. High-need, high-cost (HNHC) alcohol-related frequent…”
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Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers by McCavera, S, Walsh, T K, Wolstenholme, A J

“…SUMMARYLigand-gated chloride channels, including the glutamate-(GluCl) and GABA-gated channels, are the targets of the macrocyclic lactone (ML) family of…”
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P-glycoproteins of Haemonchus contortus: development of real-time PCR assays for gene expression studies by Williamson, S M, Wolstenholme, A J

“…P-glycoproteins (P-gps) are proteins that function as efflux pumps, removing lipophilic xenobiotic compounds from cells. There is evidence that P-gps play a…”
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Altered avr-14B gene transcription patterns in ivermectin-resistant isolates of the cattle parasites, Cooperia oncophora and Ostertagia ostertagi by El-Abdellati, A., De Graef, J., Van Zeveren, A., Donnan, A., Skuce, P., Walsh, T., Wolstenholme, A., Tait, A., Vercruysse, J., Claerebout, E., Geldhof, P.

“…[Display omitted] ► A study to investigate changes in avr-14 in ivermectin-resistant isolates of the cattle parasites Cooperia oncophora and Ostertagia…”
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Identification of ion channel genes in the Acyrthosiphon pisum genome by Dale, R. P., Jones, A. K., Tamborindeguy, C., Davies, T. G. E., Amey, J. S., Williamson, S., Wolstenholme, A., Field, L. M., Williamson, M. S., Walsh, T. K., Sattelle, D. B.

“…Aphids are major pests of crops, causing hundreds of millions of dollars worth of damage annually. Ion channel proteins are often the targets of modern…”
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Improving screening and brief intervention activities in primary health care: Secondary analysis of professional accuracy based on the AUDIT‐C by Palacio‐Vieira, J., Segura, L., Anderson, P., Wolstenholme, A., Drummond, C., Bendtsen, P., Wojnar, M., Kaner, E., Keurhorst, M.N., Steenkiste, B., Kłoda, K., Mierzecki, A., Parkinson, K., Newbury‐Birch, D., Okulicz‐Kozaryn, K., Deluca, P., Colom, J., Gual, A.

“…Introduction and objective The ODHIN trial found that training and support and financial reimbursement increased the proportion of patients that were screened…”
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Rapid selection for ivermectin resistance in Haemonchus contortus by Coles, G.C., Rhodes, A.C., Wolstenholme, A.J.

“…Lambs infected with two isolates, one British and one American, of Haemonchus contortus were treated with increasing doses of ivermectin. Eggs from the highest…”
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Allozyme analysis of Haemonchus contortus resistant and susceptible to anthelmintics, with an indication of dipeptidases associated with resistance by Šnábel, V., Königová, A., Dolinská, M., Wolstenholme, A. J., Várady, M.

“…Summary In an attempt to investigate the genetic and biochemical causes underlying resistance to anthelmintics, the trichostrongylid nematode Haemonchus…”
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The TRP channel superfamily: insights into how structure, protein-lipid interactions and localization influence function by Reaves, B J, Wolstenholme, A J

“…TRP (transient receptor potential) cationic channels are key molecules that are involved in a variety of diverse biological processes ranging from fertility to…”
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Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors by Davies, A R, Hardick, D J, Blagbrough, I S, Potter, B V, Wolstenholme, A J, Wonnacott, S

“…Methyllycaconitine (MLA), a norditerpenoid alkaloid isolated from Delphinium seeds, is one of the most potent non-proteinacious ligands that is selective for…”
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The molecular basis of the specific anti‐influenza action of amantadine by Hay, A.J., Wolstenholme, A.J., Skehel, J.J., Smith, M.H.

“…Amantadine (1‐aminoadamantane hydrochloride) is effective in the prophylaxis and treatment of influenza A infections. In tissue culture this selective,…”
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An ivermectin-sensitive glutamate-gated chloride channel subunit from Dirofilaria immitis by Yates, Darran M., Wolstenholme, Adrian J.

“…Dirofilaria immitis is a filarial nematode that infects dogs and causes cardiopulmonary disease. The most effective way of controlling the infection is by…”
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L-glutamate binding sites of parasitic nematodes: an association with ivermectin resistance? by Hejmadi, M V, Jagannathan, S, Delany, N S, Coles, G C, Wolstenholme, A J

“…Nematode membrane preparations contain high amounts of low-affinity specific L-glutamate binding sites. The numbers of these sites were increased in 2…”
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Distribution of glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus by Portillo, Virginia, Jagannathan, Suchitra, Wolstenholme, Adrian J.

“…Glutamate‐gated chloride channels (GluCl) are related to γ‐aminobutyric acid‐A (GABAA) receptors and are the target sites for the avermectin/milbemycin (A/M)…”
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Cells defective in sphingolipids biosynthesis express low amounts of muscle nicotinic acetylcholine receptor by Roccamo, A. M., Pediconi, M. F., Aztiria, E., Zanello, L., Wolstenholme, A., Barrantes, F. J.

“…The properties of the nicotinic acetylcholine receptor (AChR) are modulated by its lipid microenvironment. Studies of such modulation are hampered by the…”
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Collaborating to tackle the problem of anthelmintic resistance by Coles, G C, Jackson, F, Taylor, M A, Wolstenholme, A J

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GLC‐3: a novel fipronil and BIDN‐sensitive, but picrotoxinin‐insensitive, L‐glutamate‐gated chloride channel subunit from Caenorhabditis elegans by Horoszok, Lucy, Raymond, Valérie, Sattelle, David B, Wolstenholme, Adrian J

“…We report the cloning and expression of a novel Caenorhabditis elegans polypeptide, GLC‐3, with high sequence identity to previously cloned L‐glutamate‐gated…”
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Immunocytochemical localization of a putative inhibitory amino acid receptor subunit in the parasitic nematodes Haemonchus contortus and Ascaris suum by Skinner, T M, Bascal, Z A, Holden-Dye, L, Lunt, G G, Wolstenholme, A J

“…A rabbit antiserum was raised against a synthetic peptide corresponding to a region near the N-terminus of the Haemonchus contortus inhibitory amino acid…”
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