Search Results - "Wolpaw, Adam"

Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy by Wolpaw, Adam J., Dang, Chi V.

“…Links between oncogenic drivers and cancer cell metabolism have emerged over the past several decades, indicating that constitutive oncogenic growth signaling…”
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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis by Shimada, Kenichi, Skouta, Rachid, Kaplan, Anna, Yang, Wan Seok, Hayano, Miki, Dixon, Scott J, Brown, Lewis M, Valenzuela, Carlos A, Wolpaw, Adam J, Stockwell, Brent R

“…Editorial Summary Modulatory profiling of lethal small-molecule compounds identified FIN56 as an inducer of ferroptosis. FIN56 promotes the degradation of…”
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Pathways Involved in the Effect of Eflornithine in Neuroblastoma by Wolpaw, Adam J, Dang, Chi V

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MYC-induced metabolic stress and tumorigenesis by Wolpaw, Adam J., Dang, Chi V.

“…The MYC oncogene is commonly altered across human cancers. Distinct from the normal MYC proto-oncogene, which is under tight transcriptional, translational,…”
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Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity by Zhang, Xue, Pant, Shishir M., Ritch, Cecily C., Tang, Hsin-Yao, Shao, Hongguang, Dweep, Harsh, Gong, Yao-Yu, Brooks, Rebekah, Brafford, Patricia, Wolpaw, Adam J., Lee, Yool, Weeraratna, Ashani, Sehgal, Amita, Herlyn, Meenhard, Kossenkov, Andrew, Speicher, David, Sorger, Peter K., Santagata, Sandro, Dang, Chi V.

“…The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a context-dependent role…”
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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels by YAGODA, Nicholas, VON RECHENBERG, Moritz, SMITH, Richard, LESSNICK, Stephen L, SAHASRABUDHE, Sudhir, STOCKWELL, Brent R, ZAGANJOR, Elma, BAUER, Andras J, WAN SEOK YANG, FRIDMAN, Daniel J, WOLPAW, Adam J, SMUKSTE, Inese, PELTIER, John M, BONIFACE, J. Jay

“…Therapeutics that discriminate between the genetic makeup of normal cells and tumour cells are valuable for treating and understanding cancer. Small molecules…”
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Modulatory profiling identifies mechanisms of small molecule-induced cell death by Wolpaw, Adam J., Shimada, Kenichi, Skouta, Rachid, Welsch, Matthew E., Akavia, Uri David, Pe'er, Dana, Shaik, Fatima, Bulinski, J. Chloe, Stockwell, Brent R.

“…Cell death is a complex process that plays a vital role in development, homeostasis, and disease. Our understanding of and ability to control cell death is…”
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CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma by Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G., Giudice, Anna M., Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M., Yarmarkovich, Mark, Hofmann, Ted J., Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T., Bernt, Kathrin M., Wolpaw, Adam J., Dimitrov, Dimiter S., Li, Wei, Bosse, Kristopher R.

“…Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive…”
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Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers by Wolpaw, Adam J, Bayliss, Richard, Büchel, Gabriele, Dang, Chi V, Eilers, Martin, Gustafson, W Clay, Hansen, Gwenn H, Jura, Natalia, Knapp, Stefan, Lemmon, Mark A, Levens, David, Maris, John M, Marmorstein, Ronen, Metallo, Steven J, Park, Julie R, Penn, Linda Z, Rape, Michael, Roussel, Martine F, Shokat, Kevan M, Tansey, William P, Verba, Kliment A, Vos, Seychelle M, Weiss, William A, Wolf, Elmar, Mossé, Yaël P

“…Effective treatment of pediatric solid tumors has been hampered by the predominance of currently "undruggable" driver transcription factors. Improving outcomes…”
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Epigenetic state determines inflammatory sensing in neuroblastoma by Wolpaw, Adam J, Grossmann, Liron D, Dessau, Jessica L, Dong, May M, Aaron, Bailey J, Brafford, Patricia A, Volgina, Darya, Pascual-Pasto, Guillem, Rodriguez-Garcia, Alba, Uzun, Yasin, Arsenian-Henriksson, Marie, Powell, Jr, Daniel J, Bosse, Kristopher R, Kossenkov, Andrew, Tan, Kai, Hogarty, Michael D, Maris, John M, Dang, Chi V

“…Immunotherapy has revolutionized cancer treatment, but many cancers are not impacted by currently available immunotherapeutic strategies. Here, we investigated…”
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Multidimensional profiling in the investigation of small-molecule-induced cell death by Wolpaw, Adam J, Stockwell, Brent R

“…Numerous morphological variations of cell death have been described. These processes depend on a complex and overlapping cellular signaling network, making…”
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Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity by Varma, Hemant, Gangadhar, Nidhi M., Letso, Reka R., Wolpaw, Adam J., Sriramaratnam, Rohitha, Stockwell, Brent R.

“…Non-apoptotic cell death mechanisms are largely uncharacterized despite their importance in physiology and disease [1]. Here we sought to systematically…”
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New-Onset Hypoglycemia in a Medically Complex 6-Year-Old Girl by Wolpaw, Adam J, Trella, Jeanette D, Egan, Madalyn A, Delgado, Eva M

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Neural precursor cell influences on blood–brain barrier characteristics in rat brain endothelial cells by Lim, Joseph C, Wolpaw, Adam J, Caldwell, Maeve A, Hladky, Stephen B, Barrand, Margery A

“…Abstract This study explores the effects of neural precursor cells (NPCs) on barrier characteristics in brain vasculature. Primary rat brain endothelial cells…”
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Abstract B064: Uncovering the lineage state specific regulation of STING in neuroblastoma by Shapiro, Matthew, Mishra, Pamela, Narch, Alaa, Dessau, Jessica, Dang, Chi V., Wolpaw, Adam

“…Study Aim: This study aims to leverage our investigation of the transcriptional regulation of cGAS-STING signaling to identify the mechanisms that lead to…”
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27. KMT2A-ARHGEF12 fusion in Burkitt-like Lymphoma by Jung, Hou-Sung, Lin, Fumin, Wolpaw, Adam, Reilly, Anne F., Luo, Minjie, Wertheim, Gerald B., Li, Marilyn M.

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A Novel KMT2A-ARHGEF12 Fusion Gene Identified in a High-Grade B-cell Lymphoma by Jung, Hou-Sung, Lin, Fumin, Wolpaw, Adam, Reilly, Anne F., Margolskee, Elizabeth, Luo, Minjie, Wertheim, Gerald B., Li, Marilyn M.

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Abstract 699: NF-kB is a master regulator of resistance to therapy in high-risk neuroblastoma by Grossmann, Liron D., Uzun, Yasin, Lindsay, Jarrett, Chen, Chia-Hui, Wingrove, Catherine, Gao, Peng, Thadi, Anusha, Marshall, Quinlen, Kendsersky, Nathan M., Surrey, Lea, Martinez, Daniel, Mycek, Emily, Casey, Colleen, Krytska, Kateryna, Tsang, Matthew, Wolpaw, Adam, Groff, David N., Runbeck, Erin, McDevitt, Jayne, Diep, Dinh, Patel, Tasleema, Bernt, Kathrin M., Dang, Chi, Zhang, Kun, Mosse, Yael P., Tan, Kai, Maris, John M.

“…BACKGROUND High-risk neuroblastoma is a pediatric cancer arising from the developing sympathetic nervous system with a 50% relapse rate that is typically…”
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New-Onset Hypoglycemia in a Medically Complex 6-Year-Old Girl. Glimepiride poisoning by Wolpaw, Adam J, Trella, Jeanette D, Egan, Madalyn A, Delgado, Eva M

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Neuroblastoma by Turn, Christina S., Wolpaw, Adam J., Bosse, Kristopher R.

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