Search Results - "Wolos, Jeffrey A."

Longitudinal in Vivo Analysis of the Region-Specific Efficacy of Parathyroid Hormone in a Rat Cortical Defect Model by Komatsu, David E, Brune, Kellie A, Liu, Hong, Schmidt, Allen L, Han, Bomie, Zeng, Qing Q, Yang, Xuhao, Nunes, Jairo S, Lu, Yuefeng, Geiser, Andrew G, Ma, Yanfei L, Wolos, Jeffrey A, Westmore, Michael S, Sato, Masahiko

“…PTH has been shown to enhance fracture repair; however, exactly when and where PTH acts in this process remains to be elucidated. Therefore, we conducted a…”
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Imidazolyl benzimidazoles and imidazo[4,5- b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties by Mader, Mary, de Dios, Alfonso, Shih, Chuan, Bonjouklian, Rosanne, Li, Tiechao, White, Wesley, de Uralde, Beatriz López, Sánchez-Martinez, Concepción, del Prado, Miriam, Jaramillo, Carlos, de Diego, Eugenio, Martín Cabrejas, Luisa M., Dominguez, Carmen, Montero, Carlos, Shepherd, Timothy, Dally, Robert, Toth, John E., Chatterjee, Arindam, Pleite, Sehila, Blanco-Urgoiti, Jaime, Perez, Leticia, Barberis, Mario, Lorite, María José, Jambrina, Enrique, Nevill, C. Richard, Lee, Paul A., Schultz, Richard C., Wolos, Jeffrey A., Li, Li C., Campbell, Robert M., Anderson, Bryan D.

“…The p38 MAP kinase activity of two series of trisubstituted imidazoles (X = C, N) is reported, leading to compounds with highly potent cellular and in vivo…”
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Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model by Shou, Jianyong, Bull, Christopher M, Li, Li, Qian, Hui-Rong, Wei, Tao, Luo, Shuang, Perkins, Douglas, Solenberg, Patricia J, Tan, Seng-Lai, Chen, Xin-Yi Cynthia, Roehm, Neal W, Wolos, Jeffrey A, Onyia, Jude E

“…Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease that results in joint destruction and subsequent loss of function. To better understand…”
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Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy by de Dios, Alfonso, Shih, Chuan, López de Uralde, Beatriz, Sánchez, Concepción, del Prado, Miriam, Martín Cabrejas, Luisa M, Pleite, Sehila, Blanco-Urgoiti, Jaime, Lorite, María José, Nevill, C. Richard, Bonjouklian, Rosanne, York, Jeremy, Vieth, Michal, Wang, Yong, Magnus, Nicholas, Campbell, Robert M, Anderson, Bryan D, McCann, Denis J, Giera, Deborah D, Lee, Paul A, Schultz, Richard M, Li, Johnson, Lea M, Wolos, Jeffrey A

“…We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38α inhibitors. The lead compound 1 had low-nanomolar…”
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Cessation of dexamethasone exacerbates airway responses to methacholine in asthmatic mice by Stengel, Peter W., Nickell, Laura E., Wolos, Jeffrey A., Snyder, David W.

“…In asthmatic mice, dexamethasone (30.0 mg/kg) was administered orally once daily on Days 24–27. One hour after dexamethasone on Day 25–27, the mice were…”
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Methacholine-induced pulmonary gas trapping in a mouse model of allergic asthma: Effect of inhaled budesonide and ciglitazone by Stengel, Peter W., Zeckner, Douglas J., Guo, Wen-Kai Kevin, Wolos, Jeffrey A., Snyder, David W.

“…Previously, we found pulmonary gas trapping to be a rapid, simple and objective measure of methacholine-induced airway obstruction in naïve mice. In this study…”
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Inhibition by probucol of interleukin 1 secretion and its implication in atherosclerosis by Ku, George, Doherty, Niall S., Wolos, Jeffrey A., Jackson, Richard L., Schmidt, Lisa F., Hendricks, Deborah

“…Intravenous injection of 1.5 mg of acetylated low-density lipoprotein (LDL) or 100 μg of lipopolysaccharide (LPS) to zymosan-primed mice induced a decrease in…”
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Abstract 5325: Localized tumor growth in bone: Quantification of tumor burden, bone destruction, and weight-bearing capability in MDA-MB-231 human mammary carcinoma xenograft-bearing immunodeficient rats by Brune, Kellie A., Misener, Elizabeth A., Shannon, Harlan, Wolos, Jeffrey A.

“…Abstract Metastatic bone disease is common in multiple myeloma, breast, prostate, and lung cancer patients and is a frequent cause of morbidity in advanced…”
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Abstract 5321: Longitudinal high throughput CT imaging of orthotopic lung tumors in mice without using contrast media or respiratory gating by Bull, Christopher M., Li, Li, Westmore, Michael S., Wolos, Jeffrey A.

“…Abstract In the clinic, CT is the primary clinical imaging modality for diagnosing and staging tumors of the lungs because of its high speed, ability to…”
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Abstract B235: Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity by Campbell, Robert M., Anderson, Bryan D., Chan, Edward M., De Dios, Alfonso, Gilmour, Raymond, Hatch, Steven D., Jambrina, Enrique, Lee, Paul, Mader, Mary, Neubauer, Blake L., Pratt, Susan, Shih, Chuan, Stancato, Louis F., Starling, James J., Velasco, Juan A., Watkins, Scott A., Wolos, Jeffrey A., Ye, Xiang

“…Abstract p38α mitogen-activated protein kinase (MAPK) is activated by cancer cells in response to environmental factors, such as oncogenic stress, radiation,…”
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Induction of T helper cell hyporesponsiveness in an experimental model of autoimmunity by using nonmitogenic anti-CD3 monoclonal antibody by Hughes, C, Wolos, JA, Giannini, EH, Hirsch, R

“…Autoimmune diseases can be characterized by increases in Th cell activities, suggesting that inhibition of Th cell function might ameliorate autoimmunity. We…”
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Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy by de Dios, Alfonso, Shih, Chuan, López de Uralde, Beatriz, Sánchez, Concepción, del Prado, Miriam, Martín Cabrejas, Luisa M, Pleite, Sehila, Blanco-Urgoiti, Jaime, Lorite, María José, Nevill, Jr, C Richard, Bonjouklian, Rosanne, York, Jeremy, Vieth, Michal, Wang, Yong, Magnus, Nicholas, Campbell, Robert M, Anderson, Bryan D, McCann, Denis J, Giera, Deborah D, Lee, Paul A, Schultz, Richard M, Li, Li C, Johnson, Lea M, Wolos, Jeffrey A

“…We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had…”
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Immunosuppression mediated by an inhibitor of S-adenosyl-L-homocysteine hydrolase. Prevention and treatment of collagen-induced arthritis by Wolos, JA, Frondorf, KA, Esser, RE

“…The potent irreversible inhibitor of S-adenosyl-L-homocysteine hydrolase (Z)-5'-fluoro-4',5'-didehydro-5'-deoxyadenosine (MDL 28,842) was examined for its…”
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Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties by Mader, Mary, de Dios, Alfonso, Shih, Chuan, Bonjouklian, Rosanne, Li, Tiechao, White, Wesley, López de Uralde, Beatriz, Sánchez-Martinez, Concepción, del Prado, Miriam, Jaramillo, Carlos, de Diego, Eugenio, Martín Cabrejas, Luisa M, Dominguez, Carmen, Montero, Carlos, Shepherd, Timothy, Dally, Robert, Toth, John E, Chatterjee, Arindam, Pleite, Sehila, Blanco-Urgoiti, Jaime, Perez, Leticia, Barberis, Mario, Lorite, María José, Jambrina, Enrique, Nevill, Jr, C Richard, Lee, Paul A, Schultz, Richard C, Wolos, Jeffrey A, Li, Li C, Campbell, Robert M, Anderson, Bryan D

“…Herein we report investigations into the p38alpha MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing…”
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Selective inhibition of T cell activation by an inhibitor of S-adenosyl- L-homocysteine hydrolase by Wolos, JA, Frondorf, KA, Davis, GF, Jarvi, ET, McCarthy, JR, Bowlin, TL

“…Defects in the enzymes involved in the pathway of S-adenosylmethionine (AdoMet) metabolism, or inhibition of those enzymes, results in profound…”
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Immunomodulation by an inhibitor of S-adenosyl-L-homocysteine hydrolase: inhibition of in vitro and in vivo allogeneic responses by Wolos, J A, Frondorf, K A, Babcock, G F, Stripp, S A, Bowlin, T L

“…The response of murine T cells to MHC class II determinants on allogeneic cells induces helper T cell activation and the development of cytotoxic T cells. We…”
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Helper cells in the autologous mixed lymphocyte reaction. III. Production of helper factor(s) distinct from interleukin 2 by Wolos, J A, Smith, J B

“…In normal mice, the autologous mixed lymphocyte reaction (AMLR) can activate helper T cells that, in the presence of hapten-modified syngeneic cells, can…”
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Methylacetylenic putrescine (MAP), an inhibitor of polyamine biosynthesis, prevents the development of collagen-induced arthritis by Wolos, J A, Logan, D E, Bowlin, T L

“…The objective of the present investigation was to examine the effects of an irreversible inhibitor of ornithine decarboxylase (2R,5R)-6-heptyne-2,5,diamine…”
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Function of lymphocyte subpopulations in chronic lymphocytic leukemia. Activity in the allogeneic and autologous mixed lymphocyte reaction by Wolos, J A, Davey, F R

“…Lymphocyte subpopulations from patients with chronic lymphocytic leukemia (CLL) and from normal age-matched controls were evaluated for their ability to…”
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Effects of an S-adenosyl-l-homocysteine hydrolase inhibitor on murine macrophage activation and function by Lambert, Laurie E., Frondorf, Kathleen A., Berling, Jennifer S., Wolos, Jeffrey A.

“…The S-adenosyl-l-homocysteine (AdoHcy) hydrolase inhibitor MDL 28,842 has been demonstrated to be a potent inhibitor of T-cell activation, both in vitro and in…”
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