Search Results - "Wolmarans, De Wet"

When past and present collide: A concise clinical review of post-traumatic stress disorder (PTSD) within the context of family practice by Sarel Brand, De Wet Wolmarans

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Back to basics: A methodological perspective on marble-burying behavior as a screening test for psychiatric illness by de Brouwer, Geoffrey, Wolmarans, De Wet

“…•Quantification of MB is influenced by observer bias and burying substrate.•MB possibly results from normal exploration and is subject to habituation.•High…”
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The deer mouse (Peromyscus maniculatus bairdii) as a model organism to explore the naturalistic psychobiological mechanisms contributing to compulsive-like rigidity: A narrative overview of advances and opportunities by Theron, Vasti, Lochner, Chrstine, Stein, Dan J., Harvey, Brian H, Wolmarans, De Wet

“…Deer mice (Peromyscus maniculatus bairdii), a wildtype species native to North America, have been investigated for their spontaneous compulsive-like behaviour…”
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Escitalopram and lorazepam differentially affect nesting and open field behaviour in deer mice exposed to an anxiogenic environment by Wolmarans, De Wet, Prinsloo, Michelle, Seedat, Soraya, Stein, Dan J., Harvey, Brian H., de Brouwer, Geoffrey

“…•Large nest building (LNB) in deer mice is not modifiable by an anxiogenic setting.•LNB expressing mice show less anxiety-like and more risk-engaging…”
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Behavioral restriction, lorazepam, and escitalopram uniquely influence the expression of naturalistic stereotypy in deer mice: perspectives on anxiety- and compulsive-like behavior by Burke, Johann T, Mograbi, Daniel C, Wolmarans, De Wet

“…Stereotypical expression in laboratory-housed rodents can be explained by different motivational, coping, and motor dysfunction theories. Here, we aimed to…”
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Forced running-induced rhabdomyolysis in the Sprague–Dawley rat: towards a rodent model of capture myopathy by Lubbe, Crystal, Harvey, Brian H., Viljoen, Francois P., Meyer, Leith, Wolmarans, De Wet

“…Abstract Capture myopathy (CM) is a metabolic disease associated with mortality in mass boma captured (MBC) wildlife. The condition is induced by the forced…”
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Maintaining euthyroidism: fundamentals of thyroid hormone physiology, iodine metabolism and hypothyroidism by Wolmarans, De Wet

“…Thyroid-related pathologies, especially subclinical and clinical hypothyroidism, are commonly described in clinical practice. While illnesses related to…”
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Restoring the architecture : a rapid clinical perspective on bone-mineral density and osteoporosis by Brand, Linda, Wolmarans, De Wet

“…Osteoporosis is a highly prevalent and debilitating condition that contributes to the risk of fracture in both women and men. The current paper will provide a…”
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Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse by Güldenpfennig, Marianne, Wolmarans, De Wet, du Preez, Jan L, Stein, Dan J, Harvey, Brian H

“…Abstract The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and…”
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All headaches are not equal : a review of migraine as a state of brain dysfunction by Brand, Sarel J., Brand, Linda, Wolmarans, De Wet

“…Introduction and backgroundIndividuals suffering from migraine headache, or migraineurs as they are often referred to, and the clinicians treating them are…”
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Working around the problem : the impact of being overweight and obese on the treatment of clinical illness by Brand, Sarel, Wolmarans, De Wet, Brand, Linda

“…Overweight and obesity are not only two highly prevalent conditions in the South African society, but they also contribute to 6 of the 10 most common causes of…”
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A quick and painless reminder : the pharmacotherapy of rheumatoid arthritis in primary practice by Brand, Linda, Brand, Sarel J., Wolmarans, De Wet

“…Rheumatoid arthritis, an auto-immune disorder, is characterised by chronic inflammation of the joints, synovial hyperplasia and bone erosion. These…”
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Mind your state: Insights into antidepressant nonadherence by De Wet Wolmarans, Sarel J. Brand

“…Major depressive disorder (MDD) is an insidious disease and affects up to 15% of the global population. Although MDD responds to a wide range of…”
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Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): Response to escitalopram treatment and basal serotonin transporter (SERT) density by Wolmarans, De Wet, Brand, Linda, Stein, Dan J., Harvey, Brian H.

“…•Stereotypy is time-consuming and effective for assessing severity and drug response.•Chronic, but not sub-chronic treatment with escitalopram attenuates…”
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A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive–compulsive disorder: Mapping the way forward by de Brouwer, Geoffrey, Fick, Arina, Harvey, Brian H., Wolmarans, De Wet

“…Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic…”
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Spontaneous alternation and stereotypical behaviour in deer mice: response to escitalopram and levetiracetam by de Ridder, Maret, Mograbi, Daniel, Wolmarans, De Wet

“…Obsessive-compulsive disorder is varyingly associated with cognitive impairment, that is, deficits in spatial working memory, although it seems unlikely that…”
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Large nesting expression in deer mice remains stable under conditions of visual deprivation despite heightened limbic involvement: Perspectives on compulsive‐like behavior by Marx, Harry, Krahe, Thomas E., Wolmarans, De Wet

“…Visual stimuli and limbic activation varyingly influence obsessive‐compulsive symptom expression and so impact treatment outcomes. Some symptom phenotypes, for…”
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An evolutionary view of self-awareness by Lage, Caio A., Wolmarans, De Wet, Mograbi, Daniel C.

“…The capacity to be self-aware is regarded as a fundamental difference between humans and other species. However, growing evidence challenges this notion,…”
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Life-threatening, high-intensity trauma- and context-dependent anxiety in zebrafish and its modulation by epinephrine by Theron, Vasti, Harvey, Brian H., Botha, Tarryn, Weinshenker, David, Wolmarans, De Wet

“…Trauma-related psychopathology transpires in some individuals after exposure to a life-threatening event. While aberrant adrenergic processes may contribute to…”
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Adult Offspring of Deer Mouse Breeding Pairs Selected for Normal and Compulsive‐Like Large Nesting Expression Invariably Show the Same Behavior Without Prior In‐Breeding by Stoppel, Heike, Harvey, Brian H., Wolmarans, De Wet

“…ABSTRACT Obsessive‐compulsive disorder is a neuropsychiatric condition with notable genetic involvement. Against this background, laboratory‐housed deer mice…”
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