Search Results - "Wollerman, Krista"

Iberdomide Enhances Dara Mediated Cytotoxicity through Upregulation of CDC Activity and Elevated NK Cell Mediated ADCC by Ma, Peilin, Sridharan, Vinidhra, Wollerman, Krista, Dutta, Debjani, Singh, Ram Kumar, Mukherjee, Sambuddo, Bjorklund, Chad C., Hagner, Patrick R, Amatangelo, Michael, Gandhi, Anita K.

“…Background: Multiple Myeloma (MM) is an incurable hematological malignancy with current treatments comprising combination regimens, typically featuring…”
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CC-92480 Enhances Cell-Autonomous Cytotoxicity through Blockade of G 2/M Transition When Combined with Bortezomib/Dexamethasone in Pre-Clinical Multiple Myeloma by Bjorklund, Chad C, Amatangelo, Michael, Kang, Jian, Chiu, Hsiling, Mukhopadhyay, Archana, Wollerman, Krista, Pourdehnad, Michael, Hagner, Patrick, Thakurta, Anjan

“…Background: Pomalidomide (POM) is an established agent in relapsed/refractory (R/R) multiple myeloma (MM). CC-92480, a novel cereblon E3 ligase modulator…”
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Preclinical and Translational Biomarker Analyses to Inform Clinical Development of Mezigdomide (CC-92480) in Combination with Dexamethasone and Daratumumab in Multiple Myeloma by Chow, Tracy T., Amatangelo, Michael, Ma, Peilin, Bjorklund, Chad C., Wollerman, Krista, Civardi, Tiziana, Koo, Phillip, Zhu, Yue, Maciag, Paulo, Katz, Jessica, Raval, Aparna, Oriol, Albert, Orlowski, Robert Z., White, Darrell, Richardson, Paul G., Gandhi, Anita K.

“…Introduction: Mezigdomide (MEZI) is a novel, oral cereblon (CRBN) E3 ligase modulator (CELMoD) that induces rapid and potent degradation of lkaros and Aiolos…”
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Preclinical and Translational Data Support Development of Iberdomide in Combination with CD38- and SLAMF7-Directed Monoclonal Antibodies: Evidence for Rational Combinations by Amatangelo, Michael, Bjorklund, Chad, Ma, Peilin, Wollerman, Krista, Pierceall, William, Lonial, Sagar, van de Donk, Niels W.C.J., Popat, Rakesh, Jagannath, Sundar, Zonder, Jeffrey, Minnema, Monique C., Oriol, Albert, Larsen, Jeremy, Badros, Ashraf Z., Rodriguez-Otero, Paula, Sonneveld, Pieter, Nguyen, Tuong Vi, Hong, Kevin, Sorrell, April, Thakurta, Anjan

“…Introduction: Iberdomide (IBER; CC-220) is a potent, novel cereblon (CRBN) E3 ligase modulator (CELMoD) agent under investigation in a phase 1/2…”
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