Search Results - "Wollenberg, Gordon K."

Recombinant Rat and Mouse Growth Hormones: Risk Assessment of Carcinogenic Potential in 2-Year Bioassays in Rats and Mice by Farris, Georgia M., Miller, Glen K., Wollenberg, Gordon K., Molon-Noblot, Sylvain, Chan, Christine, Prahalada, Srinivasa

“…Recombinant rat growth hormone (rrGH) and recombinant mouse growth hormone (rmGH) were developed to evaluate the potential carcinogenicity of each biologically…”
Get full text

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia by Layton, Mark E., Kern, Jeffrey C., Hartingh, Timothy J., Shipe, William D., Raheem, Izzat, Kandebo, Monika, Hayes, Robert P., Huszar, Sarah, Eddins, Donnie, Ma, Bennett, Fuerst, Joy, Wollenberg, Gordon K., Li, Jing, Fritzen, Jeff, McGaughey, Georgia B., Uslaner, Jason M., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.

“…PDE10A is an important regulator of striatal signaling that, when inhibited, can normalize dysfunctional activity. Given the involvement of dysfunctional…”
Get full text

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties by Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G

“…Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL)…”
Get full text

Role of chronic toxicology studies in revealing new toxicities by Galijatovic-Idrizbegovic, Alema, Miller, Judith E., Cornell, Wendy D., Butler, James A., Wollenberg, Gordon K., Sistare, Frank D., DeGeorge, Joseph J.

“…Chronic (>3 months) preclinical toxicology studies are conducted to support the safe conduct of clinical trials exceeding 3 months in duration. We have…”
Get full text

Differential local and systemic regulation of the murine chemokines KC and MIP2 by Call, D R, Nemzek, J A, Ebong, S J, Bolgos, G R, Newcomb, D E, Wollenberg, G K, Remick, D G

“…We characterized the relative biological activity and expression of two murine chemokines that may serve as functional homologues for human IL-8, KC, and…”
Get more information

Tumor necrosis factor α is not required for WY14,643-induced cell proliferation by Lawrence, Jeffrey W., Wollenberg, Gordon K., DeLuca, John G.

“…It has been proposed that the cytokine tumor necrosis factor α (TNFα) stimulates peroxisome proliferator-induced hepatic cell proliferation. To test this…”
Get full text

Dexamethasone Selectively Inhibits WY14,643-Induced Cell Proliferation and Not Peroxisome Proliferation in Mice by Lawrence, Jeffrey W., Wollenberg, Gordon K., Frank, John D., DeLuca, John G.

“…It has been proposed that the hepatocellular proliferation induced by peroxisome proliferators may occur through an indirect mechanism involving cytokine…”
Get full text

Prolonged Sublethal Exposure to the Protein Phosphatase Inhibitor Microcystin-LR Results in Multiple Dose-Dependent Hepatotoxic Effects by Solter, Philip F., Wollenberg, Gordon K., Huang, Xuan, Chu, Fun S., Runnegar, Maria T.

“…The purpose of this study was to relate dose-dependent hepatotoxicity stemming from prolonged exposure to sublethal concentrations of the cyclic heptapeptide…”
Get full text

Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses by Rogy, M A, Auffenberg, T, Espat, N J, Philip, R, Remick, D, Wollenberg, G K, Copeland, 3rd, E M, Moldawer, L L

“…Anticytokine therapies have been promulgated in gram-negative sepsis as a means of preventing or neutralizing excessive production of proinflammatory…”
Get full text

Binding of tumor necrosis factor alpha to activated forms of human plasma alpha2 macroglobulin by WOLLENBERG, G. K, LAMARRE, J, ROSENDAL, S, GONIAS, S. L, HAYES, M. A

Get full text

Differential expression of tumor necrosis factor and interleukin-6 by peritoneal macrophages in vivo and in culture by Wollenberg, GK, DeForge, LE, Bolgos, G, Remick, DG

“…To investigate the differences in cytokine regulation in vitro as compared to in vivo, we examined the synthesis of tumor necrosis factor-alpha (TNF-alpha) and…”
Get full text

Inhibition of proliferation of normal, preneoplastic, and neoplastic rat hepatocytes by transforming growth factor-β by WOLLENBERG, G. K, SEMPLE, E, QUINN, B. A, HAYES, M. A

“…The influences of purified transforming growth factor beta (TGF-beta) on proliferation of normal, preneoplastic, and neoplastic rat hepatocytes were examined…”
Get full text

Effects of fumonisin-containing culture material on pulmonary clearance in swine by Smith, G W, Constable, P D, Smith, A R, Bacon, C W, Meredith, F I, Wollenberg, G K, Haschek, W M

“…To determine the potential effects of feeding tumonisin-containing culture material on the pulmonary clearance of blood-borne particulates and bacteria in…”
Get more information

Prolonged Sublethal Exposure to the Protein Phosphatase Inhibitor Microcystin-LR Results in Multiple Dose-Dependent Hepatotoxic Effects by Solter, Philip F., Wollenberg, Gordon K., Huang, Xuan, Chu, Fun S., Runnegar, Maria T.

“…The purpose of this study was to relate dose-dependent hepatotoxicity stemming from prolonged exposure to sublethal concentrations of the cyclic heptapeptide…”
Get full text

Reversible mitochondrial swelling in cultured rat hepatocytes exposed to 1,2-dimethylhydrazine by Pollanen, M S, Quinn, B A, Wollenberg, G K, Hayes, M A

“…The early structural changes of F344 rat hepatocytes exposed to the hepatocarcinogen 1,2-dimethylhydrazine (DMH) were characterized in short-term monolayer…”
Get more information