A major susceptibility locus for atopic dermatitis maps to chromosome 3q21

Atopic dermatitis (eczema) is a chronic inflammatory skin disease with onset mainly in early childhood. It is commonly the initial clinical manifestation of allergic disease, often preceding the onset of respiratory allergies. Along with asthma and allergic rhinitis, atopic dermatitis is an importan...

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Published in:	Nature genetics Vol. 26; no. 4; pp. 470 - 473
Main Authors:	Wahn, Ulrich, Reis, André, Wienker, Thomas, Gustafsson, Dan, Wolkertstorfer, Albert, Lee, Young-Ae, Oranje, Arnold P, Küster, Wolfgang, Kehrt, Rainer, Berg, Andrea v, Tarani, Luigi, Businco, Luisa, Rüschendorf, Franz, Hoffmann, Ute, Andersson, Florence
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group 01-12-2000
Subjects:	Adolescent Allergens Allergic diseases Allergies Asthma Atopic dermatitis Biological and medical sciences Child Child, Preschool Chromosome Mapping Chromosomes Chromosomes, Human, Pair 3 - genetics Dermatitis Dermatitis, Atopic - genetics Developed countries Diagnosis DNA - genetics Environmental factors Female Genes Genetic aspects Genetic factors Genetic Linkage Genetic Markers Genetics Genomes Genomic Imprinting Humans Immunopathology Linkage (Genetics) Male Medical sciences Methods Nuclear Family Pediatrics Physiological aspects Rhinitis Risk factors Siblings Skin allergic diseases. Stinging insect allergies Skin diseases Germany Sweden Netherlands Berlin Germany Genetic mapping Human Skin disease Linkage Atopic dermatitis Family study Risk factor Chromosome A3 Genetic determinism
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Summary:	Atopic dermatitis (eczema) is a chronic inflammatory skin disease with onset mainly in early childhood. It is commonly the initial clinical manifestation of allergic disease, often preceding the onset of respiratory allergies. Along with asthma and allergic rhinitis, atopic dermatitis is an important manifestation of atopy that is characterized by the formation of allergy antibodies (IgE) to environmental allergens. In the developed countries, the prevalence of atopic dermatitis is approximately 15%, with a steady increase over the past decades. Genetic and environmental factors interact to determine disease susceptibility and expression, and twin studies indicate that the genetic contribution is substantial. To identify susceptibility loci for atopic dermatitis, we ascertained 199 families with at least two affected siblings based on established diagnostic criteria. A genome-wide linkage study revealed highly significant evidence for linkage on chromosome 3q21 (Zall=4.31, P= 8.42×10−6). Moreover, this locus provided significant evidence for linkage of allergic sensitization under the assumption of paternal imprinting (hlod=3.71, α=44%), further supporting the presence of an atopy gene in this region. Our findings indicate that distinct genetic factors contribute to susceptibility to atopic dermatitis and that the study of this disease opens new avenues to dissect the genetics of atopy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1061-4036 1546-1718
DOI:	10.1038/82625