Search Results - "Wolk, D A"

Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease by Lopez, O L, Becker, J T, Wahed, A S, Saxton, J, Sweet, R A, Wolk, D A, Klunk, W, DeKosky, S T

“…Background:Patients using cholinesterase inhibitors (ChEIs) have a delay in nursing home (NH) admission compared with those who were not using the medication…”
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Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease by Chen, Y, Wolk, D A, Reddin, J S, Korczykowski, M, Martinez, P M, Musiek, E S, Newberg, A B, Julin, P, Arnold, S E, Greenberg, J H, Detre, J A

“…We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients…”
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Pathological drivers of neurodegeneration in suspected non-Alzheimer's disease pathophysiology by Wisse, L E M, de Flores, R, Xie, L, Das, S R, McMillan, C T, Trojanowski, J Q, Grossman, M, Lee, E B, Irwin, D, Yushkevich, P A, Wolk, D A

“…Little is known about the heterogeneous etiology of suspected non-Alzheimer's pathophysiology (SNAP), a group of subjects with neurodegeneration in the absence…”
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Automated Hippocampal Subfield Segmentation at 7T MRI by Wisse, L E M, Kuijf, H J, Honingh, A M, Wang, H, Pluta, J B, Das, S R, Wolk, D A, Zwanenburg, J J M, Yushkevich, P A, Geerlings, M I

“…High resolution 7T MRI is increasingly used to investigate hippocampal subfields in vivo, but most studies rely on manual segmentation which is labor…”
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Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths by Dickerson, B.C., Fenstermacher, E., Salat, D.H., Wolk, D.A., Maguire, R.P., Desikan, R., Pacheco, J., Quinn, B.T., Van der Kouwe, A., Greve, D.N., Blacker, D., Albert, M.S., Killiany, R.J., Fischl, B.

“…In normal humans, relationships between cognitive test performance and cortical structure have received little study, in part, because of the paucity of tools…”
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Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions by Wisse, L E M, Ravikumar, S, Ittyerah, R, Lim, S, Lane, J, Bedard, M L, Xie, L, Das, S R, Schuck, T, Grossman, M, Lee, E B, Tisdall, M D, Prabhakaran, K, Detre, J A, Mizsei, G, Trojanowski, J Q, Artacho-Pérula, E, de Iñiguez de Onzono Martin, M M, M Arroyo-Jiménez, M, Muñoz Lopez, M, Molina Romero, F J, P Marcos Rabal, M, Cebada Sánchez, S, Delgado González, J C, de la Rosa Prieto, C, Córcoles Parada, M, Wolk, D A, Irwin, D J, Insausti, R, Yushkevich, P A

“…The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated…”
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Deep brain stimulation for Alzheimer disease: a decision and cost-effectiveness analysis by Mirsaeedi-Farahani, Keyvan, Halpern, C. H., Baltuch, G. H., Wolk, D. A., Stein, S. C.

“…Alzheimer disease (AD) is characterized by impairments in memory function. Standard AD treatment provides marginal improvements in this domain. Recent reports,…”
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Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease by Weintraub, Daniel, Dietz, Nicole, Duda, John E., Wolk, David A., Doshi, Jimit, Xie, Sharon X., Davatzikos, Christos, Clark, Christopher M., Siderowf, Andrew

“…Research suggests overlap in brain regions undergoing neurodegeneration in Parkinson's and Alzheimer's disease. To assess the clinical significance of this, we…”
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A protocol for manual segmentation of medial temporal lobe subregions in 7 Tesla MRI by Berron, D, Vieweg, P, Hochkeppler, A, Pluta, J B, Ding, S-L, Maass, A, Luther, A, Xie, L, Das, S R, Wolk, D A, Wolbers, T, Yushkevich, P A, Düzel, E, Wisse, L E M

“…Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for…”
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Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer’s disease by Coughlin, D. G., Ittyerah, R., Peterson, C., Phillips, J. S., Miller, S., Rascovsky, K., Weintraub, D., Siderowf, A. D., Duda, J. E., Hurtig, H. I., Wolk, D. A., McMillan, C. T., Yushkevich, P. A., Grossman, M., Lee, E. B., Trojanowski, J. Q., Irwin, D. J.

“…Lewy body diseases (LBD) are characterized by alpha‐synuclein (SYN) pathology, but co‐morbid Alzheimer’s disease pathology is common and the relationship…”
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Comparison of In Vivo and Ex Vivo MRI of the Human Hippocampal Formation in the Same Subjects by Wisse, L E M, Adler, D H, Ittyerah, R, Pluta, J B, Robinson, J L, Schuck, T, Trojanowski, J Q, Grossman, M, Detre, J A, Elliott, M A, Toledo, J B, Liu, W, Pickup, S, Das, S R, Wolk, D A, Yushkevich, P A

“…Multiple techniques for quantification of hippocampal subfields from in vivo MRI have been proposed. Linking in vivo MRI to the underlying histology can help…”
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Lack of hemispheric dominance for consciousness in acute ischaemic stroke by Cucchiara, B, Kasner, S E, Wolk, D A, Lyden, P D, Knappertz, V A, Ashwood, T, Odergren, T, Nordlund, A

“…Background: Previous reports have suggested left hemispheric dominance for maintaining consciousness, although there is controversy over this claim. Objective:…”
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Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease by CHEN, Y, WOLK, D. A, DETRE, J. A, REDDIN, J. S, KORCZYKOWSKI, M, MARTINEZ, P. M, MUSIEK, E. S, NEWBERG, A. B, JULIN, P, ARNOLD, S. E, GREENBERG, J. H

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Defining SNAP by cross-sectional and longitudinal definitions of neurodegeneration by Wisse, L.E.M., Das, S.R., Davatzikos, C., Dickerson, B.C., Xie, S.X., Yushkevich, P.A., Wolk, D.A.

“…Suspected non-Alzheimer's pathophysiology (SNAP) is a biomarker driven designation that represents a heterogeneous group in terms of etiology and prognosis…”
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Plasma biomarkers of depressive symptoms in older adults by Arnold, S E, Xie, S X, Leung, Y-Y, Wang, L-S, Kling, M A, Han, X, Kim, E J, Wolk, D A, Bennett, D A, Chen-Plotkin, A, Grossman, M, Hu, W, Lee, V M-Y, Mackin, R Scott, Trojanowski, J Q, Wilson, R S, Shaw, L M

“…The pathophysiology of negative affect states in older adults is complex, and a host of central nervous system and peripheral systemic mechanisms may play…”
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Disentangling Heterogeneity in Alzheimer’s Disease and Related Dementias Using Data-Driven Methods by Habes, Mohamad, Grothe, Michel J., Tunc, Birkan, McMillan, Corey, Wolk, David A., Davatzikos, Christos

“…Brain aging is a complex process that includes atrophy, vascular injury, and a variety of age-associated neurodegenerative pathologies, together determining an…”
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Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics by Dickerson, Bradford C, Wolk, David A

“…ObjectiveTo investigate whether some patients with very mild Alzheimer's disease (AD) demonstrate disproportionate executive dysfunction relative to amnesia…”
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Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias by Yarchoan, Mark, Xie, Sharon X., Kling, Mitchel A., Toledo, Jon B., Wolk, David A., Lee, Edward B., Van Deerlin, Vivianna, Lee, Virginia M.-Y., Trojanowski, John Q., Arnold, Steven E.

“…A growing body of evidence demonstrates an association between vascular risk factors and Alzheimer’s disease. This study investigated the frequency and…”
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Combining plasma phospho-tau and accessible measures to evaluate progression to Alzheimer's dementia in mild cognitive impairment patients by Pichet Binette, Alexa, Palmqvist, Sebastian, Bali, Divya, Farrar, Gill, Buckley, Christopher J, Wolk, David A, Zetterberg, Henrik, Blennow, Kaj, Janelidze, Shorena, Hansson, Oskar

“…Up to now, there are no clinically available minimally invasive biomarkers to accurately identify mild cognitive impairment (MCI) patients who are at greater…”
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Recordings of postsubiculum head direction cells following lesions of the laterodorsal thalamic nucleus by Golob, Edward J, Wolk, David A, Taube, Jeffrey S

“…Areas of the rodent limbic system are important for solving spatial tasks and accurate navigation. Previous studies have identified cells in the postsubiculum…”
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