Search Results - "Wolin, Michael S"

Oxidant Mechanisms in Renal Injury and Disease by Ratliff, Brian B, Abdulmahdi, Wasan, Pawar, Rahul, Wolin, Michael S

“…A common link between all forms of acute and chronic kidney injuries, regardless of species, is enhanced generation of reactive oxygen species (ROS) and…”
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Reactive oxygen species and the control of vascular function by Wolin, Michael S

“…This article summarizes perspectives on how reactive oxygen species (ROS) and redox signaling mechanisms participate in regulating vascular smooth muscle…”
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Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations by Csiszar, Anna, Labinskyy, Nazar, Podlutsky, Andrej, Kaminski, Pawel M, Wolin, Michael S, Zhang, Cuihua, Mukhopadhyay, Partha, Pacher, Pal, Hu, Furong, de Cabo, Rafael, Ballabh, Praveen, Ungvari, Zoltan

“…The dietary polyphenolic compound resveratrol, by activating the protein deacetylase enzyme silent information regulator 2/sirtuin 1 (SIRT1), prolongs life…”
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Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence by Wolin, Michael S

“…Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new…”
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Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats by Csiszar, Anna, Labinskyy, Nazar, Olson, Susan, Pinto, John T, Gupte, Sachin, Wu, Joseph M, Hu, Furong, Ballabh, Praveen, Podlutsky, Andrej, Losonczy, Gyorgy, de Cabo, Rafael, Mathew, Rajamma, Wolin, Michael S, Ungvari, Zoltan

“…Proliferation of pulmonary arterial smooth muscle cells, endothelial dysfunction, oxidative stress, and inflammation promotes the development of pulmonary…”
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Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH by Serpillon, Sabrina, Floyd, Beverly C, Gupte, Rakhee S, George, Shimran, Kozicky, Mark, Neito, Venessa, Recchia, Fabio, Stanley, William, Wolin, Michael S, Gupte, Sachin A

“…Increased oxidative stress is a known cause of cardiac dysfunction in animals and patients with diabetes, but the sources of reactive oxygen species [e.g.,…”
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Exposure of mice to chronic hypoxia attenuates pulmonary arterial contractile responses to acute hypoxia by increases in extracellular hydrogen peroxide by Patel, Dhara, Alhawaj, Raed, Wolin, Michael S

“…Exposing mice to a chronic hypoxic treatment (10% oxygen, 21 days) that promotes pulmonary hypertension was observed to attenuate the pulmonary…”
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Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling by Zhang, Bin, Alruwaili, Norah, Kandhi, Sharath, Deng, Wensheng, Huang, An, Wolin, Michael S, Sun, Dong

“…Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase…”
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Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation by Orosz, Zsuzsanna, Csiszar, Anna, Labinskyy, Nazar, Smith, Kira, Kaminski, Pawel M, Ferdinandy, Peter, Wolin, Michael S, Rivera, Aracelie, Ungvari, Zoltan

“…Although the cardiovascular morbidity and mortality induced by cigarette smoking exceed those attributable to lung cancer, the molecular basis of…”
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Superoxide-Mediated Upregulation of MMP9 Participates in BMPR2 Destabilization and Pulmonary Hypertension Development by Alruwaili, Norah, Kandhi, Sharath, Froogh, Ghezal, Kelly, Melissa R, Sun, Dong, Wolin, Michael S

“…we previously reported in studies on organoid-cultured bovine pulmonary arteries that pulmonary hypertension (PH) conditions of exposure to hypoxia or…”
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Effects of hypoxia on relationships between cytosolic and mitochondrial NAD(P)H redox and superoxide generation in coronary arterial smooth muscle by Gao, Qun, Wolin, Michael S

“…Since controversy exists on how hypoxia influences vascular reactive oxygen species (ROS) generation, and our previous work provided evidence that it relaxes…”
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Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function by Csiszar, Anna, Ungvari, Zoltan, Edwards, John G, Kaminski, Pawel, Wolin, Michael S, Koller, Akos, Kaley, Gabor

“…We aimed to elucidate the possible role of phenotypic alterations and oxidative stress in age-related endothelial dysfunction of coronary arterioles…”
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Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, and potential importance of cytosolic NADPH by Wolin, Michael S, Ahmad, Mansoor, Gupte, Sachin A

“…Vascular smooth muscle (VSM) derived from pulmonary arteries generally contract to hypoxia, whereas VSM from systemic arteries usually relax, indicating the…”
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Human Cord Blood Derived Unrestricted Somatic Stem Cells Restore Aquaporin Channel Expression, Reduce Inflammation and Inhibit the Development of Hydrocephalus After Experimentally Induced Perinatal Intraventricular Hemorrhage by Purohit, Deepti, Finkel, Dina A, Malfa, Ana, Liao, Yanling, Ivanova, Larisa, Kleinman, George M, Hu, Furong, Shah, Shetal, Thompson, Carl, Joseph, Etlinger, Wolin, Michael S, Cairo, Mitchell S, La Gamma, Edmund F, Vinukonda, Govindaiah

“…Intraventricular hemorrhage (IVH) is a severe complication of preterm birth associated with cerebral palsy, intellectual disability, and commonly, accumulation…”
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Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxia by Neo, Boon Hwa, Kandhi, Sharath, Wolin, Michael S

“…We previously reported that isolated endothelium-removed bovine pulmonary arteries (BPAs) contract to hypoxia associated with removal of peroxide- and…”
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Roles for soluble guanylate cyclase and a thiol oxidation-elicited subunit dimerization of protein kinase G in pulmonary artery relaxation to hydrogen peroxide by Neo, Boon Hwa, Kandhi, Sharath, Wolin, Michael S

“…We have previously provided evidence that hydrogen peroxide (H(2)O(2)) stimulates soluble guanylate cyclase (sGC) under conditions where it relaxes isolated…”
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Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver by Gupte, Rakhee S., Floyd, Beverly C., Kozicky, Mark, George, Shimran, Ungvari, Zoltan I., Neito, Vanessa, Wolin, Michael S., Gupte, Sachin A.

“…Glucose metabolism through the glycolysis and hexosamine pathway has been shown to be altered in type 2 diabetes. However, the fate of glucose through the…”
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Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension by Gupte, Sachin A, Wolin, Michael S

“…It has been well known for >100 years that systemic blood vessels dilate in response to decreases in oxygen tension (hypoxia; low PO2), and this response…”
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D-4f induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes by KRUGER, Adam L, PETERSON, Stephen, TURKSEVEN, Saadet, KAMINSKI, Pawel M, FAN ZHANG, Frank, SHUO QUAN, WOLIN, Michael S, ABRAHAM, Nader G

“…Apolipoprotein A1 mimetic peptide, synthesized from D-amino acid (D-4F), enhances the ability of HDL to protect LDL against oxidation in atherosclerotic…”
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Roles for Nox4 in the contractile response of bovine pulmonary arteries to hypoxia by Ahmad, Mansoor, Kelly, Melissa R, Zhao, Xiangmin, Kandhi, Sharath, Wolin, Michael S

“…Hypoxia appears to promote contraction [hypoxic pulmonary vasoconstriction (HPV)] of bovine pulmonary arteries (BPA) through removal of a peroxide-mediated…”
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