Search Results - "Wolfs, Tim G.A.M."

Chorioamnionitis as a Risk Factor for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis by Been, Jasper V., MD, MPH, PhD, Lievense, Sanne, MD, Zimmermann, Luc J.I., MD, PhD, Kramer, Boris W., MD, PhD, Wolfs, Tim G.A.M., PhD

“…Objective To accumulate available evidence regarding the association between antenatal inflammation and necrotizing enterocolitis (NEC). Study design A…”
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia by Ophelders, Daan R M G, Wolfs, Tim G A M, Jellema, Reint K, Zwanenburg, Alex, Andriessen, Peter, Delhaas, Tammo, Ludwig, Anna-Kristin, Radtke, Stefan, Peters, Vera, Janssen, Leon, Giebel, Bernd, Kramer, Boris W

“…Preterm neonates are susceptible to perinatal hypoxic-ischemic brain injury, for which no treatment is available. In a preclinical animal model of…”
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Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key by Ophelders, Daan R M G, Gussenhoven, Ruth, Klein, Luise, Jellema, Reint K, Westerlaken, Rob J J, Hütten, Matthias C, Vermeulen, Jeroen, Wassink, Guido, Gunn, Alistair J, Wolfs, Tim G A M

“…With a worldwide incidence of 15 million cases, preterm birth is a major contributor to neonatal mortality and morbidity, and concomitant social and economic…”
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Systemic multipotent adult progenitor cells protect the cerebellum after asphyxia in fetal sheep by Gussenhoven, Ruth, Ophelders, Daan R.M.G., Dudink, Jeroen, Pieterman, Kay, Lammens, Martin, Mays, Robert W., Zimmermann, Luc J., Kramer, Boris W., Wolfs, Tim G.A.M., Jellema, Reint K.

“…Involvement of the cerebellum in the pathophysiology of hypoxic‐ischemic encephalopathy (HIE) in preterm infants is increasingly recognized. We aimed to assess…”
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The Mannose-Binding Lectin-Pathway Is Involved in Complement Activation in the Course of Renal Ischemia-Reperfusion Injury by de Vries, Bart, Walter, Sarah J., Peutz-Kootstra, Carine J., Wolfs, Tim G.A.M., van Heurn, L.W. Ernest, Buurman, Wim A.

“…Ischemia-reperfusion (I/R) is an important cause of acute renal failure (ARF). The complement system appears to be essentially involved in I/R injury. However,…”
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Thiol-ene conjugation of a VEGF peptide to electrospun scaffolds for potential applications in angiogenesis by Yao, Tianyu, Chen, Honglin, Wang, Rong, Rivero, Rebeca, Wang, Fengyu, Kessels, Lilian, Agten, Stijn M., Hackeng, Tilman M., Wolfs, Tim G.A.M., Fan, Daidi, Baker, Matthew B., Moroni, Lorenzo

“…Vascular endothelial growth factor (VEGF) plays a vital role in promoting attachment and proliferation of endothelial cells, and induces angiogenesis. In…”
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Electrical stimulation promotes the angiogenic potential of adipose-derived stem cells by Beugels, Jip, Molin, Daniel G. M., Ophelders, Daan R. M. G., Rutten, Teun, Kessels, Lilian, Kloosterboer, Nico, Grzymala, Andrzej A. Piatkowski de, Kramer, Boris W. W., van der Hulst, René R. W. J., Wolfs, Tim G. A. M.

“…Autologous fat transfer (AFT) is limited by post-operative volume loss due to ischemia-induced cell death in the fat graft. Previous studies have demonstrated…”
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Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2 by BROWN, Heather J, LOCK, Helen R, WOLFS, Tim G. A. M, BUURMAN, Wim A, SACKS, Steven H, ROBSON, Michael G

“…Autoimmune diseases such as glomerulonephritis are exacerbated by infection. This study examined the effect of the Toll-like receptor 4 (TLR4) ligand lipid A…”
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Breast‐Feeding Improves Gut Maturation Compared With Formula Feeding in Preterm Babies by Reisinger, Kostan W., Vaan, Loes, Kramer, Boris W., Wolfs, Tim G.A.M., Heurn, L.W. Ernest, Derikx, Joep P.M.

“…ABSTRACT Objective: The incidence of necrotizing enterocolitis (NEC) is higher in formula‐fed babies than in breast‐fed babies, which may be caused by…”
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Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs by Neuen, Sophie M.L., Ophelders, Daan R.M.G., Widowski, Helene, Hütten, Matthias C., Brokken, Tim, van Gorp, Charlotte, Nikkels, Peter G.J., Severens-Rijvers, Carmen A.H., Sthijns, Mireille M.J.P.E., van Blitterswijk, Clemens A., Troost, Freddy J., LaPointe, Vanessa L.S., Jolani, Shahab, Seiler, Christof, Pillow, J. Jane, Delhaas, Tammo, Reynaert, Niki L., Wolfs, Tim G.A.M.

“…Perinatal inflammation increases the risk for bronchopulmonary dysplasia in preterm neonates, but the underlying pathophysiological mechanisms remain largely…”
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Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep by Heymans, Cathelijne, Heij, Lara R, Lenaerts, Kaatje, den Dulk, Marcel, Hadfoune, Mhamed, van Heugten, Chantal, Spiller, Owen B, Beeton, Michael L, Stock, Sarah J, Jobe, Alan H, Payne, Matthew S, Kemp, Matthew W, Kramer, Boris W, Plat, Jogchum, van Gemert, Wim G, Wolfs, Tim G A M

“…Chorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis…”
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Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis by Klein, Luise, Ophelders, Daan R.M.G., van den Hove, Daniel, Damoiseaux, Maurits, Rutten, Bart P.F., Reutelingsperger, Chris P.M., Schurgers, Leon J., Wolfs, Tim G.A.M.

“…Systemic and cerebral inflammation following antenatal infection (e.g. chorioamnionitis) and dysregulation of the blood brain barrier (BBB) are major risk…”
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Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation by Daemen, M A, van 't Veer, C, Denecker, G, Heemskerk, V H, Wolfs, T G, Clauss, M, Vandenabeele, P, Buurman, W A

“…Ischemia followed by reperfusion leads to severe organ injury and dysfunction. Inflammation is considered to be the most important cause of tissue injury in…”
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Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut by Wolfs, Tim G.A.M., Derikx, Joep P.M., Hodin, Caroline M.I.M., Vanderlocht, Joris, Driessen, Ann, de Bruïne, Adriaan P., Bevins, Charles L., Lasitschka, Felix, Gassler, Nikolaus, van Gemert, Wim G., Buurman, Wim A.

“…Background: Microbiota in the intestinal lumen provide an abundant source of potentially detrimental antigens, including lipopolysaccharide (LPS), a potent…”
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The Effects of Dexamethasone and Oxygen in Ventilated Adult Sheep with Early Phase Acute Respiratory Distress Syndrome by Engel, Monique, Nowacki, Relana M. E., Boden, Pim, Reiss, Lucy K., Uhlig, Stefan, Reynaert, Niki L., Gopal, Poornima, Wouters, Emiel F. M., Willems, Coen H. M. P., Kloosterboer, Nico, Wolfs, Tim G. A. M., Zimmermann, Luc J. I., Vos, Gijs D., Kramer, Boris W.

“…Background Acute respiratory distress syndrome (ARDS) is a life-threating condition with high morbidity and mortality. Inflammation is the main factor in the…”
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Lysophosphatidic Acid Prevents Renal Ischemia-Reperfusion Injury by Inhibition of Apoptosis and Complement Activation by de Vries, Bart, Matthijsen, Robert A., van Bijnen, Annemarie A.J.H.M., Wolfs, Tim G.A.M., Buurman, Wim A.

“…Renal ischemia-reperfusion (I/R) injury is an important cause of acute renal failure as observed after renal transplantation, major surgery, trauma, and septic…”
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Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis by DE VRIES, Bart, WALTER, Sarah J, WOLFS, Tim G. A. M, HOCHEPIED, Tino, RÄBINÄ, Jarkko, HEERINGA, Peter, PARKKINEN, Jaakko, LIBERT, Claude, BUURMAN, Wim A

“…Although ischemia-reperfusion (I/R) injury represents a major problem in posttransplant organ failure, effective treatment is not available. The acute phase…”
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Increased release of sMD-2 during human endotoxemia and sepsis: A role for endothelial cells by Wolfs, Tim G.A.M., Dunn-Siegrist, Irène, van’t Veer, Cornelis, Hodin, Caroline M.I.M., Germeraad, Wilfred T.V., van Zoelen, Marieke A.D., van Suylen, Robert-Jan, Peutz-Kootstra, Carine J., Elson, Greg, Pugin, Jérôme, Buurman, Wim A.

“…MD-2 is the crucial cofactor of TLR4 in the detection of LPS. Here, we show that soluble MD-2 (sMD-2) circulates in plasma of healthy individuals as a…”
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Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy by Hoogenboom, Lieke A., Wolfs, Tim G. A. M., Hütten, Matthias C., Peutz-Kootstra, Carine J., Schreuder, Michiel F.

“…Prematurity and perinatal stress, such as intrauterine growth restriction (IUGR) and chorioamnionitis, are pathological processes creating an impaired…”
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Electrospun Scaffolds Functionalized with a Hydrogen Sulfide Donor Stimulate Angiogenesis by Yao, Tianyu, van Nunen, Teun, Rivero, Rebeca, Powell, Chadwick, Carrazzone, Ryan, Kessels, Lilian, Wieringa, Paul Andrew, Hafeez, Shahzad, Wolfs, Tim G.A.M., Moroni, Lorenzo, Matson, John B., Baker, Matthew B.

“…Tissue-engineered constructs are currently limited by the lack of vascularization necessary for the survival and integration of implanted tissues. Hydrogen…”
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