Search Results - "Wolfram, T"

Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines by Luca, Anna C, Mersch, Sabrina, Deenen, René, Schmidt, Stephan, Messner, Isabelle, Schäfer, Karl-Ludwig, Baldus, Stephan E, Huckenbeck, Wolfgang, Piekorz, Roland P, Knoefel, Wolfram T, Krieg, Andreas, Stoecklein, Nikolas H

“…Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared…”
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The membrane‐bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders by Keitel, Verena, Cupisti, Kenko, Ullmer, Christoph, Knoefel, Wolfram T., Kubitz, Ralf, Häussinger, Dieter

“…TGR5 (Gpbar‐1) is a plasma membrane‐bound, G protein–coupled receptor for bile acids. TGR5 messenger RNA (mRNA) has been detected in many tissues, including…”
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TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro by Reich, Maria, Deutschmann, Kathleen, Sommerfeld, Annika, Klindt, Caroline, Kluge, Stefanie, Kubitz, Ralf, Ullmer, Christoph, Knoefel, Wolfram T, Herebian, Diran, Mayatepek, Ertan, Häussinger, Dieter, Keitel, Verena

“…Cholestatic liver diseases in humans as well as bile acid (BA)-feeding and common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes…”
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Limits on the electromagnetic counterpart to S190814bv by Watson, A M, Butler, N R, Lee, W H, Becerra, R L, Pereyra, M, Angeles, F, Farah, A, Figueroa, L, Gónzalez-Buitrago, D, Quirós, F, Ruíz-Díaz-Soto, J, Tejada de Vargas, C, Tinoco, S J, Wolfram, T

“…ABSTRACT We derive limits on any electromagnetic counterpart to the compact binary merger S190814bv, whose parameters are consistent with the merger of a black…”
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XIAP mediates NOD signaling via interaction with RIP2 by Krieg, Andreas, Correa, Ricardo G, Garrison, Jason B, Le Negrate, Gaëlle, Welsh, Kate, Huang, Ziwei, Knoefel, Wolfram T, Reed, John C

“…NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the…”
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Surgical and per-oral endoscopic myotomy (POEM) for the treatment of primary esophageal motility disorders: A systematic analysis of current trends in Germany between 2011 and 2019 by Kandler, Jennis, Essing, Tobias, Schöler, David, Flügen, Georg, Knoefel, Wolfram T, Roderburg, Christoph, Luedde, Tom, Loosen, Sven H

“…While surgery remains a standard treatment for primary esophageal motility disorders (PEMDs), per-oral endoscopic myotomy (POEM) has recently evolved as an…”
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Swallowed foreign bodies in adults by Ambe, Peter, Weber, Sebastian A, Schauer, Mathias, Knoefel, Wolfram T

“…Foreign-body ingestion is a common event most often seen in children from 6 months to 6 years of age. In adults, foreign bodies are usually ingested…”
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Characterization of different CTC subpopulations in non-small cell lung cancer by Hanssen, Annkathrin, Wagner, Jenny, Gorges, Tobias M., Taenzer, Aline, Uzunoglu, Faik G., Driemel, Christiane, Stoecklein, Nikolas H., Knoefel, Wolfram T., Angenendt, Sebastian, Hauch, Siegfried, Atanackovic, Djordje, Loges, Sonja, Riethdorf, Sabine, Pantel, Klaus, Wikman, Harriet

“…Circulating tumour cells (CTCs) serve as valuable biomarkers. However, EpCAM positive CTCs are less frequently detected in NSCLC patients compared to other…”
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Para-aortic lymph nodes and ductal adenocarcinoma of the pancreas: Distant neighbors? by Safi, Sami A., Rehders, Alexander, Haeberle, Lena, Fung, Stephen, Lehwald, Nadja, Esposito, Irene, Ziayee, Farid, Krieg, Andreas, Knoefel, Wolfram T., Fluegen, Georg

“…Para-aortic lymph nodes in the ductal adenocarcinoma of the pancreatic head are regarded as distant metastases. Chemotherapy is considered the only treatment…”
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Detection of circulating tumor cells in colorectal cancer patients using the GILUPI CellCollector: results from a prospective, single‐center study by Dizdar, Levent, Fluegen, Georg, Dalum, Guus, Honisch, Ellen, Neves, Rui P., Niederacher, Dieter, Neubauer, Hans, Fehm, Tanja, Rehders, Alexander, Krieg, Andreas, Knoefel, Wolfram T., Stoecklein, Nikolas H.

“…The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample…”
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Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis by Stoecklein, Nikolas H, Fluegen, Georg, Guglielmi, Rosa, Neves, Rui P L, Hackert, Thilo, Birgin, Emrullah, Cieslik, Stefan A, Sudarsanam, Monica, Driemel, Christiane, van Dalum, Guus, Franken, André, Niederacher, Dieter, Neubauer, Hans, Fehm, Tanja, Rox, Jutta M, Böhme, Petra, Häberle, Lena, Göring, Wolfgang, Esposito, Irene, Topp, Stefan A, Coumans, Frank A W, Weitz, Jürgen, Knoefel, Wolfram T, Fischer, Johannes C, Bork, Ulrich, Rahbari, Nuh N

“…The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their extremely low concentration in the whole…”
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Wnt–β-catenin Signaling Protects Against Hepatic Ischemia and Reperfusion Injury in Mice by Lehwald, Nadja, Tao, Guo–Zhong, Jang, Kyu Yun, Sorkin, Michael, Knoefel, Wolfram T, Sylvester, Karl G

“…Background & Aims Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The…”
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FGF Signalling in the Self-Renewal of Colon Cancer Organoids by Otte, Jörg, Dizdar, Levent, Behrens, Bianca, Goering, Wolfgang, Knoefel, Wolfram T., Wruck, Wasco, Stoecklein, Nikolas H., Adjaye, James

“…The progression of colorectal cancer (CRC) is supposedly driven by cancer stem cells (CSC) which are able to self-renew and simultaneously fuel bulk tumour…”
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CXCR4/CXCR7/CXCL12 axis promotes an invasive phenotype in medullary thyroid carcinoma by Werner, Thomas A, Forster, Christina M, Dizdar, Levent, Verde, Pablo E, Raba, Katharina, Schott, Matthias, Knoefel, Wolfram T, Krieg, Andreas

“…Background: Medullary thyroid carcinoma (MTC) is a rare and challenging endocrine malignancy. Once spread, the therapeutic options are limited and the outcome…”
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CXCR4--A Prognostic and Clinicopathological Biomarker for Pancreatic Ductal Adenocarcinoma: A Meta-Analysis by Krieg, Andreas, Riemer, Jasmin C, Telan, Leila A, Gabbert, Helmut E, Knoefel, Wolfram T

“…Adenocarcinomas of the pancreatic duct (PDAC) are characteristically aggressive tumors that are extremely challenging to treat as curative surgical resection,…”
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Distribution of gastrointestinal neuroendocrine tumors in Europe: results from a retrospective cross-sectional study by Loosen, Sven H., Kostev, Karel, Jann, Henning, Tetzlaff, Fabian, Tacke, Frank, Krieg, Sarah, Knoefel, Wolfram T., Fluegen, Georg, Luedde, Tom, Krieg, Andreas, Roderburg, Christoph

“…Background Gastrointestinal (non-pancreatic) neuroendocrine tumors (GI-NETs) represent a rare but increasingly common tumor entity. Prognosis and biological…”
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Current epidemiological trends and in-hospital mortality of acute pancreatitis in Germany: a systematic analysis of standardized hospital discharge data between 2008 and 2017 by Loosen, Sven H, Essing, Tobias, Jördens, Markus, Koch, Alexander, Tacke, Frank, Knoefel, Wolfram T, Bode, Johannes, Roderburg, Christoph, Luedde, Tom

“…Acute pancreatitis (AP) represents a common gastrointestinal disorder. Complicated disease courses in particular still represent a major clinical challenge and…”
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Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis by Krieg, Andreas, Werner, Thomas A, Verde, Pablo E, Stoecklein, Nikolas H, Knoefel, Wolfram T

“…Survivin/BIRC5 is a potentially interesting prognostic marker and therapeutic target in colorectal cancer (CRC). However, the available data on survivin…”
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New model for gastroenteropancreatic large-cell neuroendocrine carcinoma: establishment of two clinically relevant cell lines by Krieg, Andreas, Mersch, Sabrina, Boeck, Inga, Dizdar, Levent, Weihe, Eberhard, Hilal, Zena, Krausch, Markus, Möhlendick, Birte, Topp, Stefan A, Piekorz, Roland P, Huckenbeck, Wolfgang, Stoecklein, Nikolas H, Anlauf, Martin, Knoefel, Wolfram T

“…Recently, a novel WHO-classification has been introduced that divided gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) according to their…”
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Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer by Stoecklein, Nikolas H., Hosch, Stefan B., Bezler, Martin, Stern, Franziska, Hartmann, Claudia H., Vay, Christian, Siegmund, Annika, Scheunemann, Peter, Schurr, Paulus, Knoefel, Wolfram T., Verde, Pablo E., Reichelt, Uta, Erbersdobler, Andreas, Grau, Roger, Ullrich, Axel, Izbicki, Jakob R., Klein, Christoph A.

“…The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To…”
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