Search Results - "Wolfman, Neil M"

The Human IL-17F/IL-17A Heterodimeric Cytokine Signals through the IL-17RA/IL-17RC Receptor Complex by Wright, Jill F, Bennett, Frann, Li, Bilian, Brooks, Jonathan, Luxenberg, Deborah P, Whitters, Matthew J, Tomkinson, Kathleen N, Fitz, Lori J, Wolfman, Neil M, Collins, Mary, Dunussi-Joannopoulos, Kyri, Chatterjee-Kishore, Moitreyee, Carreno, Beatriz M

“…IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. We recently reported…”
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Identification of an Interleukin 17F/17A Heterodimer in Activated Human CD4+ T Cells by Wright, Jill F., Guo, Yongjing, Quazi, Amira, Luxenberg, Deborah P., Bennett, Frann, Ross, John F., Qiu, Yongchang, Whitters, Matthew J., Tomkinson, Kathleen N., Dunussi-Joannopoulos, Kyri, Carreno, Beatriz M., Collins, Mary, Wolfman, Neil M.

“…IL-17F and IL-17A are members of the IL-17 pro-inflammatory cytokine family. IL-17A has been implicated in the pathogenesis of autoimmune diseases. IL-17F is a…”
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Regulation of Muscle Growth by Multiple Ligands Signaling through Activin Type II Receptors by Lee, Se-Jin, Lori A. Reed, Davies, Monique V., Stefan Girgenrath, Mary E. P. Goad, Tomkinson, Kathy N., Wright, Jill F., Christopher Barker, Gregory Ehrmantraut, James Holmstrom, Betty Trowell, Barry Gertz, Jiang, Man-Shiow, Sebald, Suzanne M., Matzuk, Martin, Li, En, Li-fang Liang, Edwin Quattlebaum, Ronald L. Stotish, Wolfman, Neil M.

“…Myostatin is a secreted protein that normally functions as a negative regulator of muscle growth. Agents capable of blocking the myostatin signaling pathway…”
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Induction of Cachexia in Mice by Systemically Administered Myostatin by Zimmers, Teresa A., Davies, Monique V., Koniaris, Leonidas G., Haynes, Paul, Esquela, Aurora F., Tomkinson, Kathy N., McPherron, Alexandra C., Wolfman, Neil M., Lee, Se-Jin

“…Mice and cattle with genetic deficiencies in myostatin exhibit dramatic increases in skeletal muscle mass, suggesting that myostatin normally suppresses muscle…”
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Activation of Latent Myostatin by the BMP-1/Tolloid Family of Metalloproteinases by Wolfman, Neil M., McPherron, Alexandra C., Pappano, William N., Davies, Monique V., Song, Kening, Tomkinson, Kathleen N., Wright, Jill F., Zhao, Liz, Sebald, Suzanne M., Greenspan, Daniel S., Lee, Se-Jin

“…Myostatin is a transforming growth factor β family member that acts as a negative regulator of skeletal muscle growth. Myostatin circulates in the blood of…”
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The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum by Hill, Jennifer J, Davies, Monique V, Pearson, Adele A, Wang, Jack H, Hewick, Rodney M, Wolfman, Neil M, Qiu, Yongchang

“…Myostatin, also known as growth and differentiation factor 8, is a member of the transforming growth factor β superfamily that negatively regulates skeletal…”
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Paracrine Actions Of Growth Differentiation Factor-9 in the Mammalian Ovary by Elvin, Julia A, Clark, Amander T, Wang, Pei, Wolfman, Neil M, Matzuk, Martin M

“…Although the transforming growth factor-β (TGF-β) superfamily is the largest family of secreted growth factors, surprisingly few downstream target genes in…”
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Inhibition of myostatin in adult mice increases skeletal muscle mass and strength by Whittemore, Lisa-Anne, Song, Kening, Li, Xiangping, Aghajanian, Jane, Davies, Monique, Girgenrath, Stefan, Hill, Jennifer J., Jalenak, Mary, Kelley, Pamela, Knight, Andrea, Maylor, Rich, O’Hara, Denise, Pearson, Adele, Quazi, Amira, Ryerson, Stephanie, Tan, Xiang-Yang, Tomkinson, Kathleen N., Veldman, Geertruida M., Widom, Angela, Wright, Jill F., Wudyka, Steve, Zhao, Liz, Wolfman, Neil M.

“…A human therapeutic that specifically modulates skeletal muscle growth would potentially provide a benefit for a variety of conditions including sarcopenia,…”
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IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22 by Wu, Paul W., Li, Jing, Kodangattil, Sreekumar R., Luxenberg, Deborah P., Bennett, Frann, Martino, Margot, Collins, Mary, Dunussi-Joannopoulos, Kyriaki, Gill, Davinder S., Wolfman, Neil M., Fouser, Lynette A.

“…Interleukin (IL) 22 is a type II cytokine that is produced by immune cells and acts on nonimmune cells to regulate local tissue inflammation. As a product of…”
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Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity by Puel, Anne, Cypowyj, Sophie, Bustamante, Jacinta, Wright, Jill F., Liu, Luyan, Lim, Hye Kyung, Migaud, Mélanie, Israel, Laura, Chrabieh, Maya, Audry, Magali, Gumbleton, Matthew, Toulon, Antoine, Bodemer, Christine, El-Baghdadi, Jamila, Whitters, Matthew, Paradis, Theresa, Brooks, Jonathan, Collins, Mary, Wolfman, Neil M., Al-Muhsen, Saleh, Galicchio, Miguel, Abel, Laurent, Picard, Capucine, Casanova, Jean-Laurent

“…Chronic mucocutaneous candidiasis disease (CMCD) is characterized by recurrent or persistent infections of the skin, nails, and oral and genital mucosae caused…”
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Regulation of Myostatin in Vivo by Growth and Differentiation Factor-Associated Serum Protein-1: A Novel Protein with Protease Inhibitor and Follistatin Domains by Hill, Jennifer J, Qiu, Yongchang, Hewick, Rodney M, Wolfman, Neil M

“…Myostatin, a member of the TGFβ superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a…”
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A fluorescent assay suitable for inhibitor screening and vanin tissue quantification by Ruan, Benfang H., Cole, Derek C., Wu, Paul, Quazi, Amira, Page, Karen, Wright, Jill F., Huang, Nelson, Stock, Joseph R., Nocka, Karl, Aulabaugh, Ann, Krykbaev, Rustem, Fitz, Lori J., Wolfman, Neil M., Fleming, Margaret L.

“…Vanin-1 is a pantetheinase that catalyzes the hydrolysis of pantetheine to produce pantothenic acid (vitamin B5) and cysteamine. Reported here is a highly…”
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Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys by NICKERSON-NUTTER, Cheryl, TCHISTIAKOVA, Lioudmila, WAHL, Alan, HERBER, Deborah, VUGMEYSTER, Yulia, WENSEL, David, WOLFMAN, Neil M, GILL, Davinder, COLLINS, Mary, DUNUSSI-JOANNOPOULOS, Kyri, SETH, Nilufer P, KASAIAN, Marion, SIBLEY, Barbara, OLLAND, Stephane, ZOLLNER, Richard, BRADY, William A, MOHLER, Kendall M, BAUM, Peter

“…To characterize the in vitro binding and effector function properties of CD20-directed small modular immunopharmaceutical (SMIP) 2LM20-4, and to compare its in…”
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Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2 by Li, Jing, Tomkinson, Kathy N, Tan, Xiang-Yang, Wu, Paul, Yan, Grace, Spaulding, Vikki, Deng, Bijia, Annis-Freeman, Bethany, Heveron, Kathleen, Zollner, Richard, De Zutter, Gerard, Wright, Jill F, Crawford, Tara K, Liu, Wei, Jacobs, Kenneth A, Wolfman, Neil M, Ling, Vincent, Pittman, Debra D, Veldman, Geertruida M, Fouser, Lynette A

“…Interleukin 22 (IL-22) is a cytokine induced during both innate and adaptive immune responses. It can effect an acute phase response, implicating a role for…”
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Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family by Wolfman, N M, Hattersley, G, Cox, K, Celeste, A J, Nelson, R, Yamaji, N, Dube, J L, DiBlasio-Smith, E, Nove, J, Song, J J, Wozney, J M, Rosen, V

“…Little is known about the regulatory signals involved in tendon and ligament formation, and this lack of understanding has hindered attempts to develop…”
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A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos by Gamer, L W, Wolfman, N M, Celeste, A J, Hattersley, G, Hewick, R, Rosen, V

“…The bone morphogenetic proteins (BMPs) play critical roles in patterning the early embryo and in the development of many organs and tissues. We have identified…”
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Nodal Signaling Uses Activin and Transforming Growth Factor-β Receptor-regulated Smads by Kumar, Amit, Novoselov, Vladimir, Celeste, Anthony J., Wolfman, Neil M., ten Dijke, Peter, Kuehn, Michael R.

“…Nodal, a member of the transforming growth factor β (TGF-β) superfamily, is implicated in many events critical to the early vertebrate embryo, including…”
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Gdf-8 Propeptide Binds to GDF-8 and Antagonizes Biological Activity by Inhibiting GDF-8 Receptor Binding by Tries, R. Scott, Chen, Tom, Da Vies, Monique V., Tomkinson, Kathy N., Pearson, Adele A., Shakey, Quazi A., Wolfman, Neil M.

“…Abstract GDF-8 is a new member of the TGF-β superfamily which appears to be a negative regulator of skeletal muscle mass. Factors which regulate the biological…”
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derriere: a TGF-beta family member required for posterior development in Xenopus by Sun, B I, Bush, S M, Collins-Racie, L A, LaVallie, E R, DiBlasio-Smith, E A, Wolfman, N M, McCoy, J M, Sive, H L

“…TGF-beta signaling plays a key role in induction of the Xenopus mesoderm and endoderm. Using a yeast-based selection scheme, we isolated derriere, a novel…”
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223 IL-22R, IL-10R2 and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22 by Wu, Paul W., Li, Jing, Kodangattil, Sreekumar R., Luxenberg, Deborah P., Bennett, Frann, Martino, Margot, Collins, Mary, Dunussi-Joannopoulos, Kyriaki, Gill, Davinder S., Wolfman, Neil M., Fouser, Lynette A.

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