Search Results - "Wolfman, Claudia"

Anxioselective properties of 6,3′-dinitroflavone, a high-affinity benzodiazepine receptor ligand by Wolfman, Claudia, Viola, Haydeé, Marder, Mariel, Wasowski, Cristina, Ardenghi, Patricia, Izquierdo, Iván, Paladini, Alejandro C, Medina, Jorge H

“…6,3′-Dinitroflavone is a synthetic flavone derivative with high affinity for central benzodiazepine receptors that has anxiolytic effects. Here, we describe…”
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6-Bromoflavone, a High Affinity Ligand for the Central Benzodiazepine Receptors Is a Member of a Family of Active Flavonoids by Marder, Mariel, Viola, Haydee, Wasowski, Cristina, Wolfman, Claudia, Waterman, Peter G., Cassels, Bruce K., Medina, Jorge H., Paladini, Alejandro C.

“…6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki=70 nM and has a clear anxiolytic activity in mice, at…”
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Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea by Wolfman, C, Viola, H, Paladini, A, Dajas, F, Medina, J H

“…The pharmacological effects of 5,7-dihydroxyflavone (chrysin), a naturally occurring monoflavonoid that displaces [3H]flunitrazepam binding to the central…”
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Overview-flavonoids : A new family of benzodiazepine receptor ligands by MEDINA, J. H, VIOLA, H, WOLFMAN, C, MARDER, M, WASOWSKI, C, CALVO, D, PALADINI, A. C

“…Benzodiazepines (BDZs) are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side-effects that…”
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Detection of Benzodiazepine Receptor Ligands in Small Libraries of Flavone Derivatives Synthesized by Solution Phase Combinatorial Chemistry by Marder, Mariel, Viola, Haydee, Bacigaluppo, José A., Colombo, Marı́a I., Wasowski, Cristina, Wolfman, Claudia, Medina, Jorge H., Rúveda, Edmundo A., Paladini, Alejandro C.

“…Solution phase combinatorial synthesis of flavone derivatives and evaluation of their affinity for the central benzodiazepine receptors is described. The…”
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The “Anxiety State” and Its Relation with Rat Models of Memory and Habituation by Ribeiro, Rafaela L., Andreatini, Roberto, Wolfman, Claudia, Viola, Haydeé, Medina, Jorge H., Da Cunha, Claudio

“…Rats selected as “anxious”, “nonanxious,” or normal according to their behavior in an elevated plus maze were submitted to memory tasks and the densities of…”
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Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties by Medina, J H, Paladini, A C, Wolfman, C, Levi de Stein, M, Calvo, D, Diaz, L E, Peña, C

“…Chrysin (5,7-di-OH-flavone) was identified in Passiflora coerulea L., a plant used as a sedative in folkloric medicine. Chrysin was found to be a ligand for…”
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Ricinine-Elicited Seizures: A Novel Chemical Model of Convulsive Seizures by Ferraz, Anete C, Pereira, Luiz Fernando, Ribeiro, Rafaela L, Wolfman, Claudia, Medina, Jorge H, Scorza, Fúlvio A, Santos, Neide F, Cavalheiro, Esper A, Da Cunha, Claudio

“…The present investigation introduces ricinine-elicited seizures as a novel chemical model of convulsive seizure. Ricinine, a neutral alkaloid obtained from the…”
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Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor by Marde, Mariel, Zinczuk, Juan, Colombo, María I., Wasowski, Cristina, Viola, Haydee, Wolfman, Claudia, Medina, Jorge H., Rúveda, Edmundo A., Paladini, Alejandro C.

“…A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R)…”
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6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties by Marder, Mariel, Viola, Haydee, Wasowski, Cristina, Wolfman, Claudia, Waterman, Peter G., Medina, Jorge H., Paladini, Alejandro C.

“…6,3'-Dinitroflavone (2) and 6,4'-dinitroflavone (3), prepared by direct nitration of flavone (1), were found to be ligands for the benzodiazepine receptor…”
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6-Methyl-3′-bromoflavone, a High-Affinity Ligand for the Benzodiazepine Binding Site of the GABAA Receptor with Some Antagonistic Properties by Viola, Haydee, Marder, Mariel, Nuñez, Julian, Izquierdo, Luciana, Wasowski, Cristina, Wolfman, Claudia, Ardenghi, Patricia, Barros, Daniela, Medina, Jorge H., Paladini, Alejandro C.

“…6-Methyl-3′-bromoflavone inhibited [3H]flunitrazepam binding to the benzodiazepine binding site of the GABAA receptor (BDZ-bs) with Ki values between 10 and 50…”
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Ricinine-Elicited Seizures by Ferraz, Anete C, Pereira, Luiz Fernando, Ribeiro, Rafaela L, Wolfman, Claudia, Medina, Jorge H, Scorza, Fúlvio A, Santos, Neide F, Cavalheiro, Esper A, Da Cunha, Claudio

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Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4 by Wolfman, C, Abó, V, Calvo, D, Medina, J, Dajas, F, Silveira, R

“…The long-term effects of the systemic administration of DSP4 (N-(2-chloroethyl)N-ethyl-2-bromobenzylamine hydrochloride), a selective noradrenergic neurotoxin,…”
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6-Methyl-3'-bromoflavone, a high-affinity ligand for the benzodiazepine binding site of the GABA(A) receptor with some antagonistic properties by Viola, H, Marder, M, Nuñez, J, Izquierdo, L, Wasowski, C, Wolfman, C, Ardenghi, P, Barros, D, Medina, J H, Paladini, A C

“…6-Methyl-3'-bromoflavone inhibited [(3)H]flunitrazepam binding to the benzodiazepine binding site of the GABA(A) receptor (BDZ-bs) with Ki values between 10…”
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6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites by Viola, Haydee, Marder, Mariel, Wolfman, Claudia, Wasowski, Cristina, Medina, Jorge H., Paladini, Alejandro C.

“…The synthesis and biochemical characterization of 6-bromo-3′-nitroflavone ( 1) is presented. Compound 1 has higher affinity for cerebellar and cerebral…”
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Inhibitory Avoidance Training Induces Rapid and Selective Changes in3[H]AMPA Receptor Binding in the Rat Hippocampal Formation by CAMMAROTA, MARTÍN, IZQUIERDO, IVÁN, WOLFMAN, CLAUDIA, LEVI DESTEIN, MIGUELINA, BERNABEU, RAMÓN, JERUSALINSKY, DIANA, MEDINA, JORGE H.

“…The AMPA receptor has been shown to participate in the synaptic mechanisms involved in certain forms of learning and memory. We have previously demonstrated…”
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Proconvulsant and 'anxiogenic' effects of n-butyl beta carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain by Novas, M L, Wolfman, C, Medina, J H, de Robertis, E

“…The discovery of n-butyl beta carboline-3-carboxylate (beta CCB) as an endogenous substance of brain capable of interacting with the central benzodiazepine…”
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Habituation and inhibitory avoidance training alter brain regional levels of benzodiazepine-like molecules and are affected by intracerebral flumazenil microinjection by Wolfman, C, Da Cunha, C, Jerusalinsky, D, Levi de Stein, M, Viola, H, Izquierdo, I, Medina, J H

“…The effects of habituation and inhibitory avoidance training on the rat brain regional levels of benzodiazepine (BZD)-like molecules and on central type BZD…”
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Effect of various training procedures on performance in an elevated plus-maze: possible relation with brain regional levels of benzodiazepine-like molecules by Da Cunha, C, De Stein, M L, Wolfman, C, Koya, R, Izquierdo, I, Medina, J H

“…Rats submitted to one, two, or seven sessions of exploration to a new environment (habituation) or exposed to an inhibitory avoidance training showed different…”
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Intrahippocampal or intraamygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat by Wolfman, C, Fin, C, Dias, M, Bianchin, M, Da Silva, R C, Schmitz, P K, Medina, J H, Izquierdo, I

“…We investigated the effect of a bilateral post-training intracerebral infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II…”
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