Search Results - "Wolff, Sheldon M."

Detection of circulating tumor necrosis factor after endotoxin administration by Michie, H R, Manogue, K R, Spriggs, D R, Revhaug, A, O'Dwyer, S, Dinarello, C A, Cerami, A, Wolff, S M, Wilmore, D W

“…Cytokines, products of stimulated macrophages, are thought to mediate many host responses to bacterial infection, but increased circulating cytokine…”
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The Role of Interleukin-1 in Disease by Dinarello, Charles A, Wolff, Sheldon M

“…The interleukin-1 family consists of three structurally related polypeptides. The first two are interleukin-1α and interleukin-1β, each of which has a broad…”
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Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome by Dinarello, Charles A, Gelfand, Jeffrey A, Wolff, Sheldon M

“…The systemic inflammatory response syndrome (SIRS) is an acute illness characterized by generalized activation of the endothelium. The most severe form of the…”
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Cyclophosphamide therapy of severe systemic necrotizing vasculitis by Fauci, A S, Katz, P, Haynes, B F, Wolff, S M

“…We studied 17 patients with severe systemic necrotizing vasculitis over an 11-year-period. Sixteen patients were treated daily with cyclophosphamide (2 mg per…”
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Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 1984. 81: 7907-7911 by Auron, Philip E, Webb, Andrew C, Rosenwasser, Lanny J, Mucci, Steven F, Rich, Alexander, Wolff, Sheldon M, Dinarello, Charles A

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The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells by Endres, S, Ghorbani, R, Kelley, V E, Georgilis, K, Lonnemann, G, van der Meer, J W, Cannon, J G, Rogers, T S, Klempner, M S, Weber, P C

“…We examined whether the synthesis of interleukin-1 or tumor necrosis factor, two cytokines with potent inflammatory activities, is influenced by dietary…”
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Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1 by Porat, Reuven, Clark, Burton D., Wolff, Sheldon M., Dinarello, Charles A.

“…Interleukin-1 (IL-1) is a polypeptide cytokine that mediates many physiological responses to infection and inflammation and is a growth factor for certain…”
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Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans by Granowitz, E V, Porat, R, Mier, J W, Pribble, J P, Stiles, D M, Bloedow, D C, Catalano, M A, Wolff, S M, Dinarello, C A

“…A phase I study of human recombinant interleukin-1 receptor antagonist (IL-1ra) was conducted in healthy males between the ages of 18 and 30. Twenty-five…”
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Lack of clinical usefulness of the limulus test in the diagnosis of endotoxemia by Elin, R J, Robinson, R A, Levine, A S, Wolff, S M

“…Studies of the clinical value of the limulus amebocyte lysate test for the detection of endotoxemia are inconsistent. In an attempt to define the value of this…”
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Monoclonal Antibodies and the Treatment of Gram-Negative Bacteremia and Shock by Wolff, Sheldon M

“…It has been 40 years since the first description of bacteremia due to gram-negative rods appeared. 1 It has always been assumed that the endotoxins…”
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The Role of Iron in Nonspecific Resistance to Infection Induced by Endotoxin by Elin, Ronald J, Wolff, Sheldon M

“…Studies using an experimental model of the mouse and Candida albicans as the challenge organism attempted to define better the mechanism of nonspecific…”
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Ciliary neurotrophic factor is an endogenous pyrogen by Shapiro, L, Zhang, X X, Rupp, R G, Wolff, S M, Dinarello, C A

“…Fever is initiated by the action of polypeptide cytokines called endogenous pyrogens, which are produced by the host during inflammation, trauma, or infection…”
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Lymphomatoid Granulomatosis. Prospective clinical and therapeutic experience over 10 years by Fauci, A S, Haynes, B F, Costa, J, Katz, P, Wolff, S M

“…Fifteen patients with lymphomatoid granulomatosis were studied prospectively over a 10-year period. Thirteen of the patients received the therapeutic protocol…”
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Mechanisms of Disease: The Role of Interleukin-1 in Disease by Epstein, Franklin H, Dinarello, Charles A, Wolff, Sheldon M

“…Early studies in humans suggest that soluble type I receptors can be administered safely and that they block inflammation. Since they are a component of the…”
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Comparison of Hematologic and Febrile Response to Endotoxin in Man by Wolff, Sheldon M, Rubenstein, Melvin, Mulholland, John H, Alling, David W

“…THE PROFOUND HEMATOLOGIC alterations evoked in experimental animals following endotoxin administration have been considered to play a major role in the…”
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Effect of Bacterial Endotoxin on Experimental Fungal Infections by Kimball, Harry R, Williams, Temple W, Wolff, Sheldon M

“…Escherichia coli endotoxin was administered to mice prior to challenge with 5 × 106 Candida albicans, 5 × 106 Rhizopus arrhizus or 1 × 106 Blastomyces…”
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Pathogenesis of fever in man by Dinarello, C A, Wolff, S M

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The HA-1A Monoclonal Antibody for Gram-Negative Sepsis by Gazmuri, Raul J, Mecher, Carter, Weil, Max Harry, Tanio, Craig P, Feldman, Harold I, Carlet, J, Offenstadt, G, Chastang, C, Doyon, F, Brun-Buisson, C, Dhainaut, J.F, Schlemmer, B, Gutmann, L, Schmidt, Gregory A, Peled, Harry B, Mackenzie, S, Kinsella, J, Young, Lowell S, Gorelick, Kenneth J, Baumgartner, Jean-Daniel, Heumann, Didier, Glauser, Michel-Pierre, Ziegler, Elizabeth J, Fisher, Charles J, Sprung, Charles L, Smith, Craig R, Straube, Richard C, Sadoff, Jerald C, Dellinger, R. Phillip, Wolff, Sheldon M

“…To the Editor: Ziegler and collaborators (Feb. 14 issue) 1 recently reported on an impressive reduction in 28-day mortality, from 49 percent to 30 percent, in…”
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The treatment of gram-negative bacteremia and shock by Wolff, S M

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Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation by McAdam, K P, Elin, R J, Sipe, J D, Wolff, S M

“…Secondary amyloidosis is a complication of diseases characterized by recurrent acute inflammation. In this study, a standardized stimulus which induced fever…”
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