Search Results - "Wolff, Karen"

Synthesis and Structure-Activity relationship of covalent inhibitors of SARS-CoV-2 papain-like protease with antiviral potency by Rouch, Catherine C, Chatterjee, Arnab K, McCarty, Connor, Song, Lirui, Chu, Alan, Johnson, Kristen, Heacock, Mina, Riva, Laura, McNamara, Case W, Wolff, Karen C, Greene-Cramer, Rebecca, Falco, Anna De, Montelione, Gaetano T, Grabovyi, Gennadii A

“…The papain-like protease (PLpro) is a highly conserved domain encoded by the coronavirus (CoV) genome and it plays an essential role in the replication and…”
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RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment by Li, Zhiqun, Wolff, Karen C, Samuel, Charles E

“…Abstract Two size forms of ADAR1 adenosine deaminase are known, one constitutively expressed (p110) and the other interferon (IFN)-induced (p150). To test the…”
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Discovery of CMX990: A Potent SARS-CoV‑2 3CL Protease Inhibitor Bearing a Novel Warhead by Dayan Elshan, N. G. R., Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.

“…There remains a need to develop novel SARS-CoV-2 therapeutic options that improve upon existing therapies by an increased robustness of response, fewer safety…”
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Correction to “Discovery of CMX990: A Potent SARS-CoV‑2 3CL Protease Inhibitor Bearing a Novel Warhead” by Elshan, N. G. R. Dayan, Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Liu, Dongdong, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.

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Dexamethasone inhibits respiratory syncytial virus-driven mucus production while increasing viral replication without altering antiviral interferon signaling by McAllister, Christopher S., Ansaldi, Dan, Growcott, Ellena J., Zhong, Yang, Quackenbush, Doug, Wolff, Karen C., Chen, Zhong, Tanaseichuk, Olga, Lelais, Gerald, Barnes, S. Whitney, Federe, Glenn C., Luna, Fabio, Walker, John R., Zhou, Yingyao, Kuhen, Kelli L.

“…Respiratory syncytial virus (RSV) infection can cause mucus overproduction and bronchiolitis in infants leading to severe disease and hospitalization. As a…”
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Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I by Jiang, Tao, Kuhen, Kelli L., Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Wu, Tom Yao-Hsing, He, Yun

“…A novel oxindole was discovered as an HIV non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Systematic structural modifications…”
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Drug repurposing screens identify chemical entities for the development of COVID-19 interventions by Bakowski, Malina A., Beutler, Nathan, Wolff, Karen C., Kirkpatrick, Melanie G., Chen, Emily, Nguyen, Tu-Trinh H., Riva, Laura, Shaabani, Namir, Parren, Mara, Ricketts, James, Gupta, Anil K., Pan, Kastin, Kuo, Peiting, Fuller, MacKenzie, Garcia, Elijah, Teijaro, John R., Yang, Linlin, Sahoo, Debashis, Chi, Victor, Huang, Edward, Vargas, Natalia, Roberts, Amanda J., Das, Soumita, Ghosh, Pradipta, Woods, Ashley K., Joseph, Sean B., Hull, Mitchell V., Schultz, Peter G., Burton, Dennis R., Chatterjee, Arnab K., McNamara, Case W., Rogers, Thomas F.

“…The ongoing pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), necessitates strategies to identify prophylactic and…”
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Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2 by Jiang, Tao, Kuhen, Kelli L., Wolff, Karen, Yin, Hong, Bieza, Kimberly, Caldwell, Jeremy, Bursulaya, Badry, Tuntland, Tove, Zhang, Kanyin, Karanewsky, Donald, He, Yun

“…A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent…”
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Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV) by Bonavia, Aurelio, Franti, Michael, Pusateri Keaney, Erin, Kuhen, Kelli, Seepersaud, Mohindra, Radetich, Branko, Shao, Jian, Honda, Ayako, Dewhurst, Janetta, Balabanis, Kara, Monroe, James, Wolff, Karen, Osborne, Colin, Lanieri, Leanne, Hoffmaster, Keith, Amin, Jakal, Markovits, Judit, Broome, Michelle, Skuba, Elizabeth, Cornella-Taracido, Ivan, Joberty, Gerard, Bouwmeester, Tewis, Hamann, Lawrence, Tallarico, John A, Tommasi, Ruben, Compton, Teresa, Bushell, Simon M

“…The search for novel therapeutic interventions for viral disease is a challenging pursuit, hallmarked by the paucity of antiviral agents currently prescribed…”
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Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication by Garcia, Gustavo, Sharma, Arun, Ramaiah, Arunachalam, Sen, Chandani, Purkayastha, Arunima, Kohn, Donald B., Parcells, Mark S., Beck, Sebastian, Kim, Heeyoung, Bakowski, Malina A., Kirkpatrick, Melanie G., Riva, Laura, Wolff, Karen C., Han, Brandon, Yuen, Constance, Ulmert, David, Purbey, Prabhat K., Scumpia, Philip, Beutler, Nathan, Rogers, Thomas F., Chatterjee, Arnab K., Gabriel, Gülsah, Bartenschlager, Ralf, Gomperts, Brigitte, Svendsen, Clive N., Betz, Ulrich A.K., Damoiseaux, Robert D., Arumugaswami, Vaithilingaraja

“…SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throughput drug-screening system and identified a small-molecule…”
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“UnPAKing” Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV Infection by NGUYEN, Deborah G, WOLFF, Karen C, HONG YIN, CALDWELL, Jeremy S, KUHEN, Kelli L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo by Zhou, Nian E., Tang, Su, Bian, Xuelin, Parai, Maloy K., Krieger, Inna V., Flores, Armando, Jaiswal, Pradeep K., Bam, Radha, Wood, Jeremy L., Shi, Zhe, Stevens, Laura J., Scobey, Trevor, Diefenbacher, Meghan V., Moreira, Fernando R., Baric, Thomas J., Acharya, Arjun, Shin, Joonyoung, Rathi, Manish M., Wolff, Karen C., Riva, Laura, Bakowski, Malina A., McNamara, Case W., Catanzaro, Nicholas J., Graham, Rachel L., Schultz, David C., Cherry, Sara, Kawaoka, Yoshihiro, Halfmann, Peter J., Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P., Sacchettini, James C.

“…Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a…”
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Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening by Nguyen, Deborah G, Yin, Hong, Zhou, Yingyao, Wolff, Karen C, Kuhen, Kelli L, Caldwell, Jeremy S

“…Abstract Despite decades of research, HIV remains a global health threat. Issues of multi-drug resistance and lack of an effective vaccine have recently led to…”
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Mutations in an Auxin Receptor Homolog AFB5 and in SGT1b Confer Resistance to Synthetic Picolinate Auxins and Not to 2,4-Dichlorophenoxyacetic Acid or Indole-3-Acetic Acid in Arabidopsis by Walsh, Terence A, Neal, Roben, Merlo, Ann Owens, Honma, Mary, Hicks, Glenn R, Wolff, Karen, Matsumura, Wendy, Davies, John P

“…Although a wide range of structurally diverse small molecules can act as auxins, it is unclear whether all of these compounds act via the same mechanisms that…”
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Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors by Ellis, David, Kuhen, Kelli L., Anaclerio, Beth, Wu, Baogen, Wolff, Karen, Yin, Hong, Bursulaya, Badry, Caldwell, Jeremy, Karanewsky, Donald, He, Yun

“…A novel series of quinolones was discovered as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) using a structure-based approach. The lead…”
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The Music Marketplace And The Music Teacher: A Modern Dilemma by Wolff, Karen L.

“…The music educator of the 20th century is faced with a problem of combining the teaching of the classics in an environment that is predominantly influenced by…”
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Chemical Genetic Identification of Glutamine Phosphoribosylpyrophosphate Amidotransferase as the Target for a Novel Bleaching Herbicide in Arabidopsis by Walsh, Terence A, Bauer, Teresa, Neal, Roben, Merlo, Ann Owens, Schmitzer, Paul R, Hicks, Glenn R, Honma, Mary, Matsumura, Wendy, Wolff, Karen, Davies, John P

“…A novel phenyltriazole acetic acid compound (DAS734) produced bleaching of new growth on a variety of dicotyledonous weeds and was a potent inhibitor of…”
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The Nonmusical Outcomes of Music Education: A Review of the Literature by Wolff, Karen I.

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Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1 by Wu, Baogen, Kuhen, Kelli, Ngoc Nguyen, Truc, Ellis, David, Anaclerio, Beth, He, Xiaohui, Yang, Kunyong, Karanewsky, Donald, Yin, Hong, Wolff, Karen, Bieza, Kimberly, Caldwell, Jeremy, He, Yun

“…N-Aryl pyrrolidinones as novel anti-HIV-1 agents is reported. The synthesis and preliminary structure–activity relationship of a series of pyrrolidinones are…”
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Vaccinia Virus E3L Interferon Resistance Protein Inhibits the Interferon-Induced Adenosine Deaminase A-to-I Editing Activity by Liu, Yong, Wolff, Karen C., Jacobs, Bertram L., Samuel, Charles E.

“…The RNA-specific adenosine deaminase (ADAR1) is an interferon-inducible editing enzyme that converts adenosine to inosine. ADAR1 contains three distinct…”
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