Pre‐existing sleep problems as a predictor of post‐acute sequelae of COVID‐19

Summary Several months after COVID‐19 many individuals still report persisting symptoms, the so‐called ‘post‐COVID‐19 syndrome’. An immunological dysfunction is one of the main pathophysiological hypotheses. As sleep is central to the functioning of the immune system, we investigated whether self‐re...

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Published in:	Journal of sleep research Vol. 33; no. 2; pp. e13949 - n/a
Main Authors:	Schilling, Claudia, Nieters, Alexandra, Schredl, Michael, Peter, Raphael S., Rothenbacher, Dietrich, Brockmann, Stefan O., Göpel, Siri, Kindle, Gerhard, Merle, Uta, Steinacker, Jürgen M., Kern, Winfried, August, Dietrich, Bauer, Christoph, Blankenhorn, Benedict, Bopp‐Haas, Ulrike, Bunk, Stefanie, Deibert, Peter, Dietz, Armin, Friedmann‐Bette, Birgit, Giesen, Roland, Götz, Veronika, Grote, Sylvia, Grüner, Beate, Junginger, Alexandra, Kappert, Oliver, Kirsten, Johannes, Kräusslich, Hans‐Georg, Kühn, Anne, Malek, Nisar P., Müller, Barbara, Niess, Andreas, Pfau, Stefanie, Piechotowski, Isolde, Rieg, Siegbert, Röttele, Sibylle, Schellenberg, Jana, Schröder, Chantal, Schwertz, Rainer, Spannenkrebs, Monika, Wagner, Gabriele, Walter‐Frank, Birgit, Wolfers, Kersten
Format:	Journal Article
Language:	English
Published:	England 01-04-2024
Subjects:	post‐COVID‐19 syndrome risk factor sleep disturbance sleep disturbance post-COVID-19 syndrome risk factor
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Summary:	Summary Several months after COVID‐19 many individuals still report persisting symptoms, the so‐called ‘post‐COVID‐19 syndrome’. An immunological dysfunction is one of the main pathophysiological hypotheses. As sleep is central to the functioning of the immune system, we investigated whether self‐reported pre‐existing sleep disturbance might be an independent risk factor for the development of post‐COVID‐19 syndrome. A total of 11,710 participants of a cross‐sectional survey (all tested positive for severe acute respiratory syndrome coronavirus‐2) were classified into probable post‐COVID‐19 syndrome, an intermediate group, and unaffected participants at an average of 8.5 months after infection. The case definition was based on newly occurring symptoms of at least moderate severity and ≥20% reduction in health status and/or working capacity. Unadjusted and adjusted odds ratios were calculated to investigate the association between pre‐existing sleep disturbances and subsequent development of post‐COVID‐19 syndrome while controlling for a variety of demographic, lifestyle, and health factors. Pre‐existing sleep disturbances were found to be an independent predictor of subsequent probable post‐COVID‐19 syndrome (adjusted odds ratio 2.7, 95% confidence interval 2.27–3.24). Sleep disturbances as part of the post‐COVID‐19 syndrome were reported by more than half of the participants and appeared to be a new symptom and to occur independent of a mood disorder in most cases. Recognition of disturbed sleep as an important risk factor for post‐COVID‐19 syndrome should promote improved clinical management of sleep disorders in the context of COVID‐19. Further, it may stimulate further research on the effect of improving sleep on the prognosis of COVID‐19 long‐term sequelae and other post‐viral conditions.
Bibliography:	Additional members of the EPILOC Phase 1 Study Group: Dietrich August, Christoph Bauer, Benedict Blankenhorn, Ulrike Bopp‐Haas, Stefanie Bunk, Peter Deibert, Armin Dietz, Birgit Friedmann‐Bette, Roland Giesen, Veronika Götz, Sylvia Grote, Beate Grüner, Alexandra Junginger, Oliver Kappert, Johannes Kirsten, Hans‐Georg Kräusslich, Anne Kühn, Nisar P. Malek, Barbara Müller, Andreas Niess, Stefanie Pfau, Isolde Piechotowski, Siegbert Rieg, Sibylle Röttele, Jana Schellenberg, Chantal Schröder, Rainer Schwertz, Monika Spannenkrebs, Gabriele Wagner, Birgit Walter‐Frank, Kersten Wolfers. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0962-1105 1365-2869
DOI:	10.1111/jsr.13949