Search Results - "Wolfe, H"

Origin of the Yeast Whole-Genome Duplication by Wolfe, Kenneth H

“…Whole-genome duplications (WGDs) are rare evolutionary events with profound consequences. They double an organism's genetic content, immediately creating a…”
Get full text

An Evolutionary Perspective on Yeast Mating-Type Switching by Hanson, Sara J, Wolfe, Kenneth H

“…Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved…”
Get full text

GenomeVx: simple web-based creation of editable circular chromosome maps by Conant, Gavin C., Wolfe, Kenneth H.

“…We describe GenomeVx, a web-based tool for making editable, publication-quality, maps of mitochondrial and chloroplast genomes and of large plasmids. These…”
Get full text

Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins by Offei, Benjamin, Braun-Galleani, Stephanie, Venkatesh, Anjan, Casey, William T, O'Connor, Kevin E, Byrne, Kevin P, Wolfe, Kenneth H

“…The yeast Komagataella phaffii (formerly called Pichia pastoris) is used widely as a host for secretion of heterologous proteins, but only a few isolates of…”
Get full text

The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species by Byrne, Kevin P, Wolfe, Kenneth H

“…We developed the Yeast Gene Order Browser (YGOB; http://wolfe.gen.tcd.ie/ygob) to facilitate visual comparisons and computational analysis of synteny…”
Get full text

Widespread paleopolyploidy in model plant species inferred from age distributions of duplicate genes by Blanc, G, Wolfe, K.H

“…It is often anticipated that many of today's diploid plant species are in fact paleopolyploids. Given that an ancient large-scale duplication will result in an…”
Get full text

Functional divergence of duplicated genes formed by polyploidy during Arabidopsis evolution by Blanc, G, Wolfe, K.H

“…To study the evolutionary effects of polyploidy on plant gene functions, we analyzed functional genomics data for a large number of duplicated gene pairs…”
Get full text

A widespread inversion polymorphism conserved among Saccharomyces species is caused by recurrent homogenization of a sporulation gene family by Salzberg, Letal I, Martos, Alexandre A R, Lombardi, Lisa, Jermiin, Lars S, Blanco, Alfonso, Byrne, Kevin P, Wolfe, Kenneth H

“…Saccharomyces genomes are highly collinear and show relatively little structural variation, both within and between species of this yeast genus. We…”
Get full text

Evolutionary restoration of fertility in an interspecies hybrid yeast, by whole-genome duplication after a failed mating-type switch by Ortiz-Merino, Raúl A, Kuanyshev, Nurzhan, Braun-Galleani, Stephanie, Byrne, Kevin P, Porro, Danilo, Branduardi, Paola, Wolfe, Kenneth H

“…Many interspecies hybrids have been discovered in yeasts, but most of these hybrids are asexual and can replicate only mitotically. Whole-genome duplication…”
Get full text

Population genomics shows no distinction between pathogenic Candida krusei and environmental Pichia kudriavzevii: One species, four names by Douglass, Alexander P, Offei, Benjamin, Braun-Galleani, Stephanie, Coughlan, Aisling Y, Martos, Alexandre A R, Ortiz-Merino, Raúl A, Byrne, Kevin P, Wolfe, Kenneth H

“…We investigated genomic diversity of a yeast species that is both an opportunistic pathogen and an important industrial yeast. Under the name Candida krusei,…”
Get full text

SMURF: Genomic mapping of fungal secondary metabolite clusters by Khaldi, Nora, Seifuddin, Fayaz T., Turner, Geoff, Haft, Daniel, Nierman, William C., Wolfe, Kenneth H., Fedorova, Natalie D.

“…Fungi produce an impressive array of secondary metabolites (SMs) including mycotoxins, antibiotics and pharmaceuticals. The genes responsible for their…”
Get full text

Mating-type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces cerevisiae system by Hanson, Sara J., Byrne, Kevin P., Wolfe, Kenneth H.

“…Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-like loci…”
Get full text

Transduction Characteristics of Adeno-associated Virus Vectors Expressing Cap Serotypes 7, 8, 9, and Rh10 in the Mouse Brain by Cearley, Cassia N, Wolfe, John H

“…Recombinant adeno-associated viral (AAV) vectors can transduce cells of the CNS, resulting in long-term expression. AAV vector transduction varies depending on…”
Get full text

RNAi in Budding Yeast by Drinnenberg, Ines A, Weinberg, David E, Xie, Kathleen T, Mower, Jeffrey P, Wolfe, Kenneth H, Fink, Gerald R, Bartel, David P

“…RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model…”
Get full text

Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome by Gordon, Jonathan L, Byrne, Kevin P, Wolfe, Kenneth H

“…Comparative genomics can be used to infer the history of genomic rearrangements that occurred during the evolution of a species. We used the principle of…”
Get full text

A recent polyploidy superimposed on older large-scale duplications in the Arabidopsis genome by Blanc, Guillaume, Hokamp, Karsten, Wolfe, Kenneth H

“…The Arabidopsis genome contains numerous large duplicated chromosomal segments, but the different approaches used in previous analyses led to different…”
Get full text

Mechanisms of chromosome number evolution in yeast by Gordon, Jonathan L, Byrne, Kevin P, Wolfe, Kenneth H

“…The whole-genome duplication (WGD) that occurred during yeast evolution changed the basal number of chromosomes from 8 to 16. However, the number of…”
Get full text

The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis by Pryszcz, Leszek P, Németh, Tibor, Saus, Ester, Ksiezopolska, Ewa, Hegedűsová, Eva, Nosek, Jozef, Wolfe, Kenneth H, Gacser, Attila, Gabaldón, Toni

“…Candida metapsilosis is a rarely-isolated, opportunistic pathogen that belongs to a clade of pathogenic yeasts known as the C. parapsilosis sensu lato species…”
Get full text

Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport by Castle, Michael J, Gershenson, Zachary T, Giles, April R, Holzbaur, Erika L F, Wolfe, John H

“…Adeno-associated virus (AAV) vectors often undergo long-distance axonal transport after brain injection. This leads to transduction of brain regions distal to…”
Get more information

Evolutionary instability of CUG-Leu in the genetic code of budding yeasts by Krassowski, Tadeusz, Coughlan, Aisling Y., Shen, Xing-Xing, Zhou, Xiaofan, Kominek, Jacek, Opulente, Dana A., Riley, Robert, Grigoriev, Igor V., Maheshwari, Nikunj, Shields, Denis C., Kurtzman, Cletus P., Hittinger, Chris Todd, Rokas, Antonis, Wolfe, Kenneth H.

“…The genetic code used in nuclear genes is almost universal, but here we report that it changed three times in parallel during the evolution of budding yeasts…”
Get full text