N-Alkyl-N-arylmethylpiperidin-4-amines: Novel dual inhibitors of serotonin and norepinephrine reuptake

A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 16; no. 10; pp. 2714 - 2718
Main Authors:	Boot, J.R., Boulet, S.L., Clark, B.P., Cases-Thomas, M.J., Delhaye, L., Diker, K., Fairhurst, J., Findlay, J., Gallagher, P.T., Gilmore, J., Harris, J.R., Masters, J.J., Mitchell, S.N., Naik, M., Simmonds, R.G., Smith, S.M., Richards, S.J., Timms, G.H., Whatton, M.A., Wolfe, C.N., Wood, V.A.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 15-05-2006 Elsevier
Subjects:	Aminopiperidines Biological and medical sciences Inhibitors Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Norepinephrine Norepinephrine - antagonists & inhibitors Pharmacology. Drug treatments Piperidines - chemistry Piperidines - pharmacology Reuptake Serotonin Serotonin Uptake Inhibitors - chemistry Serotonin Uptake Inhibitors - pharmacology Structure-Activity Relationship Transporter Reuptake Norepinephrine Inhibitors Serotonin Transporter Aminopiperidines Biological transport Catecholamine Reuptake inhibitor In vitro Biological activity Amine Piperidine derivatives Neurotransmitter Chemical synthesis
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Summary:	A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of N-alkyl-N-arylmethylpiperidin-4-amines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2006.02.008