Search Results - "Wolfe, Amanda L."

Generating Publishable Data from Course-Based Undergraduate Research Experiences in Chemistry by Wolfe, Amanda L., Steed, P. Ryan

“…Embedding Course-based Undergraduate Research Experiences (CUREs) into chemistry curricula has become a best practice due to the overwhelming evidence that…”
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Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study by Ballard, T. Eric, Richards, Justin J., Wolfe, Amanda L., Melander, Christian

“…A second‐generation library of 2‐aminoimidazole‐based derivatives incorporating a “reversed amide” (RA) motif in comparison to the marine natural product…”
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Integration of Antimicrobials and Delivery Systems: Synergistic Antibiofilm Activity with Biodegradable Nanoemulsions Incorporating Pseudopyronine Analogs by Park, Jungmi, Mahida, Neel, Ho, Gabrielle, Pena, Elizabeth, Makabenta, Jessa Marie V, Aneke, Stanley, Jiang, Mingdi, Bouthillette, Leah M, Holz, Stephanie E, Hassan, Muhammad Aamir, Wolfe, Amanda L, Rotello, Vincent M

“…Multi-drug-resistant (MDR) bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), pose a significant challenge in healthcare settings. Small…”
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A Fundamental Relationship between Hydrophobic Properties and Biological Activity for the Duocarmycin Class of DNA-Alkylating Antitumor Drugs: Hydrophobic-Binding-Driven Bonding by Wolfe, Amanda L, Duncan, Katharine K, Lajiness, James P, Zhu, Kaicheng, Duerfeldt, Adam S, Boger, Dale L

“…Two systematic series of increasingly hydrophilic derivatives of duocarmycin SA that feature the incorporation of ethylene glycol units (n = 1–5) into the…”
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Development of a Robust and Quantitative High-Throughput Screening Method for Antibiotic Production in Bacterial Libraries by Murray, Elizabeth M, Allen, Catherine F, Handy, Tess E, Huffine, Clair A, Craig, Whitney R, Seaton, Sarah C, Wolfe, Amanda L

“…Over the past 30 years, there has been a dramatic rise in the number of infections caused by multidrug-resistant bacteria, which have proliferated due to the…”
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Total Synthesis of Kopsinine by Xie, Jian, Wolfe, Amanda L, Boger, Dale L

“…The use of a powerful intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of an 1,3,4-oxadiazole in the divergent total synthesis of kopsinine (1), featuring…”
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Total synthesis and antibacterial evaluation of Empetroxepins A and B and related analogs by Murphy, Kyle E., Thacher, Marcia K., Young, Erin C., Mojik, Veronika, Wolfe, Amanda L.

“…[Display omitted] Empetroxepins A and B, which are 10,11-dihydrodibenz[b,f]oxepins produced by the Black Crowberry (Empetrum nigrum), displayed weak…”
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Bisbenzamidine and Bisbenzguanidine Ureas Act as Antibacterial Agents against Pseudomonas aeruginosa by Kellogg, Casey N., Pugh, Bryce A., Starr, Isaak M., Parmar, Dhruvi J., Troxler, A'Zane D., Wolfe, Amanda L.

“…Due to the global rise in the number of antibiotic resistant bacterial infections over the past 20 years, there is a dire need for the development of small…”
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Design and evaluation of poly-nitrogenous adjuvants capable of potentiating antibiotics in Gram-negative bacteria by Pugh, Bryce A, Rao, Aliyah B, Angeles-Solano, Michelle, Grosser, Melinda R, Brock, John W, Murphy, Kyle E, Wolfe, Amanda L

“…Antibiotic resistance has been a growing public health crisis since the 1980s. Therefore, it is essential not only to continue to develop novel antibiotics but…”
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Amine Basicity of Quinoline ATP Synthase Inhibitors Drives Antibacterial Activity against Pseudomonas aeruginosa by Ward, Katie T., Williams, Alexander P. L., Blair, Courtney A., Chatterjee, Ananya M., Karthikeyan, Abirami, Roper, Addison S., Kellogg, Casey N., Steed, P. Ryan, Wolfe, Amanda L.

“…Pseudomonas aeruginosa (PA), a Gram-negative pathogen, is a common cause of nosocomial infections, especially in immunocompromised and cystic fibrosis…”
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Short chain α-pyrones capable of potentiating penicillin G against Pseudomonas aeruginosa by Fields, Lauren, Craig, Whitney R., Huffine, Clair A., Allen, Catherine F., Bouthillette, Leah M., Chappell, Jacob C., Shumate, Jacob T., Wolfe, Amanda L.

“…[Display omitted] The dramatic increase in bacterial resistance over the past three decades has greatly reduced the effectiveness of nearly all clinical…”
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Isolation of the antibiotic pseudopyronine B and SAR evaluation of C3/C6 alkyl analogs by Bouthillette, Leah M., Darcey, Catherine A., Handy, Tess E., Seaton, Sarah C., Wolfe, Amanda L.

“…[Display omitted] Natural products are an abundant source of structurally diverse compounds with antibacterial activity that can be used to develop new and…”
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Advances in antibiotic drug discovery: reducing the barriers for antibiotic development by Murphy, Kyle E, Sloan, Grace F, Lawhern, Grace V, Volk, Grace E, Shumate, Jacob T, Wolfe, Amanda L

“…Antibiotic drug discovery has been an essential field of research since the early 1900s, but the threat from infectious bacteria has only increased over the…”
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A Novel, Unusually Efficacious Duocarmycin Carbamate Prodrug That Releases No Residual Byproduct by Wolfe, Amanda L, Duncan, Katharine K, Parelkar, Nikhil K, Weir, Scott J, Vielhauer, George A, Boger, Dale L

“…A unique heterocyclic carbamate prodrug of seco-CBI-indole2 that releases no residual byproduct is reported as a new member of a class of hydrolyzable prodrugs…”
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Quinoline Compounds Targeting the c -Ring of ATP Synthase Inhibit Drug-Resistant Pseudomonas aeruginosa by Fraunfelter, Vesper M, Pugh, Bryce A, Williams, Alexander P L, Ward, Katie T, Jackson, Dietrich O, Austin, Molly, Ciprich, John F, Dippy, Lorelei, Dunford, Jason, Edwards, G Nathaniel, Glass, Evan, Handy, Kyle M, Kellogg, Casey N, Llewellyn, Kaitlyn, Nyberg, K Quinn, Shepard, Sam J, Thomas, Casey, Wolfe, Amanda L, Steed, P Ryan

“…(PA) is a Gram-negative, biofilm-forming bacterium and an opportunistic pathogen. The growing drug resistance of PA is a serious threat that necessitates the…”
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Efficacious Cyclic N‑Acyl O‑Amino Phenol Duocarmycin Prodrugs by Wolfe, Amanda L, Duncan, Katharine K, Parelkar, Nikhil K, Brown, Douglas, Vielhauer, George A, Boger, Dale L

“…Two novel cyclic N-acyl O-amino phenol prodrugs are reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family of…”
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Synthesis and Evaluation of Pseudomonas aeruginosa ATP Synthase Inhibitors by Ciprich, John F., Buckhalt, Alexander J. E., Carroll, Lane L., Chen, David, DeFiglia, Steven A., McConnell, Riley S., Parmar, Dhruvi J., Pistor, Olivia L., Rao, Aliyah B., Rubin, M. Lillian, Volk, Grace E., Steed, P. Ryan, Wolfe, Amanda L.

“…New antibiotics with unique biological targets are desperately needed to combat the growing number of resistant bacterial pathogens. ATP synthase, a critical…”
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Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers by Vielhauer, George A., Swink, Megan, Parelkar, Nikhil K., Lajiness, James P., Wolfe, Amanda L., Boger, Dale

“…In treating cancer with clinically approved chemotherapies, the high systemic toxicity and lack of selectivity for malignant cells often result in an overall…”
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Synthesis and Evaluation of Cyclic seco-CBI-indole 2 Prodrugs and Water-Soluble Duocarmycin Analogs by Wolfe, Amanda L

“…The duocarmycins are a potent class of naturally occurring antitumor antibiotics. They derive their cytotoxic activity from a sequence selective minor groove…”
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Esterase activity of glycosylasparaginase by Risley, John Marcus, Zohby, Rana, Boone, Christopher D, Cimino, Scott A, Wolfe, Amanda L

“…Glycosylasparaginase (GA) catalyzes the hydrolysis of the N‐glycosylic bond in β‐N‐acetylglucosaminyl‐L‐asparagine to give N‐acetylglucosamine, aspartic acid…”
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