Search Results - "Wolf, DM"

Control, exploitation and tolerance of intracellular noise by Rao, Christopher V, Wolf, Denise M, Arkin, Adam P

“…Noise has many roles in biological function, including generation of errors in DNA replication leading to mutation and evolution, noise-driven divergence of…”
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Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS viral infection by Ayasoufi, Katayoun, Wolf, Delaney M., Namen, Shelby L., Jin, Fang, Tritz, Zachariah P., Pfaller, Christian K., Zheng, Jiaying, Goddery, Emma N., Fain, Cori E., Gulbicki, Lauren R., Borchers, Anna L., Reesman, Rachael A., Yokanovich, Lila T., Maynes, Mark A., Bamkole, Michael A., Khadka, Roman H., Hansen, Michael J., Wu, Long-Jun, Johnson, Aaron J.

“…Healthy brain harbors populations of resident memory T cells (TRM). These TRM cells rapidly proliferate in response to CNS insults of various origins…”
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Abstract P3-10-06: Expression-based immune signatures as predictors of neoadjuvant targeted-/chemo-therapy response: Experience from the I-SPY 2 TRIAL of ˜1000 patients across 10 therapies by Yau, C, Wolf, DM, Campbell, M, Savas, P, Lin, S, Brown-Swigart, L, Hirst, G, Asare, S, Zhu, Z, Loi, S, DeMichele, A, Yee, D, Berry, D, Esserman, L, van 't Veer, L

“…Abstract Background: Expression-based signatures have been shown to predict neoadjuvant therapy response; but further studies are needed to deconvolve the…”
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Diversity in times of adversity: probabilistic strategies in microbial survival games by Wolf, Denise M., Vazirani, Vijay V., Arkin, Adam P.

“…Population diversification strategies are ubiquitous among microbes, encompassing random phase-variation ( RPV) of pathogenic bacteria, viral latency as…”
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Motifs, modules and games in bacteria by Wolf, Denise M, Arkin, Adam P

“…Global explorations of regulatory network dynamics, organization and evolution have become tractable thanks to high-throughput sequencing and molecular…”
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Abstract P3-10-02: Identifying breast cancer molecular phenotypes to predict response in a modern treatment landscape: Lessons from ˜1000 patients across 10 arms of the I-SPY 2 TRIAL by Wolf, DM, Yau, C, Wulfkuhle, J, Petricoin, E, Campbell, M, Brown-Swigart, L, Hirst, G, Asare, S, Zhu, Z, Lee, EP, Delson, A, Pohlmann, P, Hylton, N, Liu, MC, Symmans, F, DeMichele, A, Yee, D, Berry, D, Esserman, L, van 't Veer, L

“…Abstract Background: The explosion in new treatment options targeting immune checkpoints, HER signaling, DNA repair deficiency, AKT, and other pathways calls…”
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Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells by Richer, Jennifer K, Jacobsen, Britta M, Manning, Nicole G, Abel, M Greg, Wolf, Douglas M, Horwitz, Kathryn B

“…The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological functions, and their ratio varies widely in breast cancers. To determine…”
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Abstract P3-05-02: Quantitative ERα measurements in TNBC from the I-SPY 2 TRIAL correlate with HER2-EGFR co-activation and heterodimerization by Gallagher, RI, Yau, C, Wolf, DM, Dong, T, Hirst, G, Brown-Swigart, L, Buxton, M, DeMichele, A, van't Veer, L, Yee, D, Paoloni, M, Esserman, L, Berry, D, Park, J, Petricoin, EF, Wulfkuhle, JD

“…Abstract Background: We have previously described that TNBC patients whose tumors have both HER2 Y1248 phosphorylation (pHER2) “high” and phospho-EGFR Y1173…”
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Abstract S2-06: DNA repair deficiency biomarkers and MammaPrint high1/(ultra)high2 risk as predictors of veliparib/carboplatin response: Results from the neoadjuvant I-SPY 2 trial for high risk breast cancer by Wolf, DM, Yau, C, Sanil, A, Glas, A, Petricoin, C, Wulfkuhle, J, Brown-Swigart, L, Hirst, G, Buxton, M, DeMichele, A, Hylton, N, Symmans, F, Yee, D, Paoloni, M, Esserman, L, Berry, D, Rugo, H, Olapade, O, van 't Veer, L

“…Abstract Background: The PARP inhibitor veliparib in combination with carboplatin (VC) was one of the experimental regimens evaluated in the phase 2…”
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Abstract P4-09-02: A robust signature of long-term clinical outcome in breast cancer by Boudreau, A, Elias, SG, Yau, C, Wolf, DM, van't Veer, LJ

“…Abstract Background: Multigene prognostic signatures derived from high-dimensional mRNA expression data have been proposed to forecast patient outcome and…”
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Abstract P1-02-06: Assigning luminal A versus luminal B subtype using the Ki67 index in patients with hormone receptor positive (HR+) breast cancer enrolled in the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657) by Wolf, DM, Keck, S, Yau, C, Livasy, C, Mori, M, Baehner, R, van 't Veer, L, Esserman, L, Rugo, H

“…Abstract Background: Prognostically distinct subtypes of BC defined by gene expression include luminal A, luminal B, HER2-enriched, basal-like and normal…”
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Abstract P3-07-48: Prediction of complete pathologic response to veliparib/carboplatin plus standard neoadjuvant therapy in HER2 negative breast cancer: Exploratory protein pathway marker results from the I-SPY 2 trial by Wulfkuhle, JD, Yau, C, Wolf, DM, Gallagher, RI, Deng, J, Brown-Swigart, L, Hirst, G, I-SPY 2 Trial, Investigators, Rugo, H, Olopade, OI, Esserman, L, Berry, D, van't Veer, L, Petricoin, EF

“…Abstract Background: In the I-SPY 2 TRIAL, HER2- patients were randomized to receive standard chemotherapy or chemotherapy plus the oral PARP inhibitor…”
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The Six1 Homeoprotein Stimulates Tumorigenesis by Reactivation of Cyclin A1 by Coletta, Ricardo D., Christensen, Kimberly, Reichenberger, Kelly J., Lamb, Justin, Micomonaco, Damian, Huang, Lili, Wolf, Douglas M., Müller-Tidow, Carsten, Golub, Todd R., Kawakami, Kiyoshi, Ford, Heide L., Pardee, Arthur B.

“…Homeobox genes constitute a large family of transcription factors that are essential during normal development and are often dysregulated in cancer. However,…”
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Inhibition of JNK reduces G2 M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells by MINGO-SION, Amy M, MARIETTA, Peter M, KOLLER, Erich, WOLF, Douglas M, VAN DEN BERG, Carla L

“…c-Jun N-terminal kinase (JNK) is activated by diverse cell stimuli, including stress, growth factors, and cytokines. Traditionally, activation of JNK by stress…”
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Abstract P2-05-01: Gene expression changes associated with response to neoadjuvant chemotherapy are observed early in treatment: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657) by Wolf, DM, Yau, C, Magbanua, M, Boudreau, A, Davis, S, Haqq, C, Park, J, Esserman, L, van't Veer, L

“…Abstract Background: Prior gene expression profiling studies have identified markers that are predictive of chemotherapy response using pre-treatment biopsies…”
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Progesterone inhibits human endometrial cancer cell growth and invasiveness: Down-regulation of cellular adhesion molecules through progesterone B receptors by DONGHAI DAI, WOLF, Douglas M, LITMAN, Elizabeth S, WHITE, Michael J, LESLIE, Kimberly K

“…Progesterone is a critical steroid hormone that controls cell proliferation and differentiation in the female reproductive tract. Progesterone acts through two…”
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P5-01-05: Activating Mutations in PIK3CA or AKT1 in the I-SPY 1 Trial (CALGB 150007/150012; ACRIN 6657) by Boudreau, A, Yau, C, Petrillo, L, Stemke-Hale, K, Mills, GB, Gray, JW, Wolf, DM, van ‘t Veer, LJ

“…Abstract Background Mutations in the catalytic domain of phosphatidylinositol 3-kinase (PIK3CA) are among the most frequently observed activating mutations in…”
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P1-06-09: Patient-Specific Integrative Pathway Analysis Using PARADIGM Identifies Key Activities in I-SPY 1 Breast Cancer Patients (CALGB 150007/150012; ACRIN 6657) by Wolf, DM, Yau, C, Benz, S, Vaske, C, Stuart, J, Roy, R, Olshen, A, Boudreau, A, Haussler, D, Gray, J, Spellman, P, Davis, S, Hylton, N, Van Veer, L, Esserman, L

“…Abstract Background: A major challenge in interpreting high-throughput multianalyte genomic data sets such as those produced by the ISPY clinical trials is…”
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Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin by Bhatia, Neehar, Zhao, Jifu, Wolf, Douglas M., Agarwal, Rajesh

“…Several studies from our laboratory have shown the cancer chemopreventive and anti-carcinogenic effects of silymarin, a flavonoid antioxidant isolated from…”
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The Bacillus subtilis sin Operon: An Evolvable Network Motif by Voigt, Christopher A, Wolf, Denise M, Arkin, Adam P

“…The strategy of combining genes from a regulatory protein and its antagonist within the same operon, but controlling their activities differentially, can lead…”
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