Search Results - "Wolenski, Francis"

NF-κB: where did it come from and why? by Gilmore, Thomas D., Wolenski, Francis S.

“…The vast majority of research on nuclear factor κB (NF‐κB) signaling in the past 25 years has focused on its roles in normal and disease‐related processes in…”
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Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort by Church, Rachel J., Kullak‐Ublick, Gerd A., Aubrecht, Jiri, Bonkovsky, Herbert L., Chalasani, Naga, Fontana, Robert J., Goepfert, Jens C., Hackman, Frances, King, Nicholas M. P., Kirby, Simon, Kirby, Patrick, Marcinak, John, Ormarsdottir, Sif, Schomaker, Shelli J., Schuppe‐Koistinen, Ina, Wolenski, Francis, Arber, Nadir, Merz, Michael, Sauer, John‐Michael, Andrade, Raul J., van Bömmel, Florian, Poynard, Thierry, Watkins, Paul B.

“…Current blood biomarkers are suboptimal in detecting drug‐induced liver injury (DILI) and predicting its outcome. We sought to characterize the natural…”
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Microinjection of mRNA or morpholinos for reverse genetic analysis in the starlet sea anemone, Nematostella vectensis by Layden, Michael J, Röttinger, Eric, Wolenski, Francis S, Gilmore, Thomas D, Martindale, Mark Q

“…We describe a protocol for microinjection of embryos for an emerging model system, the cnidarian sea anemone, Nematostella vectensis . In addition, we provide…”
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Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice by Mosedale, Merrie, Cai, Yanwei, Eaddy, J. Scott, Kirby, Patrick J., Wolenski, Francis S., Dragan, Yvonne, Valdar, William

“…[Display omitted] Development of TAK-875 was discontinued when a small number of serious drug-induced liver injury (DILI) cases were observed in Phase 3…”
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The beagle dog MicroRNA tissue atlas: identifying translatable biomarkers of organ toxicity by Koenig, Erik M, Fisher, Craig, Bernard, Hugues, Wolenski, Francis S, Gerrein, Joseph, Carsillo, Mary, Gallacher, Matt, Tse, Aimy, Peters, Rachel, Smith, Aaron, Meehan, Alexa, Tirrell, Stephen, Kirby, Patrick

“…MicroRNAs (miRNA) are varied in length, under 25 nucleotides, single-stranded noncoding RNA that regulate post-transcriptional gene expression via…”
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Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury by Wolenski, Francis S, Zhu, Andy Z X, Johnson, Mike, Yu, Shaoxia, Moriya, Yuu, Ebihara, Takuya, Csizmadia, Vilmos, Grieves, Jessica, Paton, Martin, Liao, Mingxiang, Gemski, Christopher, Pan, Liping, Vakilynejad, Majid, Dragan, Yvonne P, Chowdhury, Swapan K, Kirby, Patrick J

“…Fasiglifam (TAK-875), a Free Fatty Acid Receptor 1 (FFAR1) agonist in development for the treatment of type 2 diabetes, was voluntarily terminated in phase 3…”
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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury by Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A

“…Abstract TAK-875 (fasiglifam), a GPR40 agonist in development for the treatment of type 2 diabetes (T2D), was voluntarily terminated in Phase III trials due to…”
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Characterizing the spatiotemporal expression of RNAs and proteins in the starlet sea anemone, Nematostella vectensis by Wolenski, Francis S, Layden, Michael J, Martindale, Mark Q, Gilmore, Thomas D, Finnerty, John R

“…In an effort to reconstruct the early evolution of animal genes and proteins, there is an increasing focus on basal animal lineages such as sponges,…”
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NF-κB is required for cnidocyte development in the sea anemone Nematostella vectensis by Wolenski, Francis S., Bradham, Cynthia A., Finnerty, John R., Gilmore, Thomas D.

“…The sea anemone Nematostella vectensis (Nv) is a leading model organism for the phylum Cnidaria, which includes anemones, corals, jellyfishes and hydras. A…”
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Identification of microRNA biomarker candidates in urine and plasma from rats with kidney or liver damage by Wolenski, Francis S., Shah, Pooja, Sano, Tomoya, Shinozawa, Tadahiro, Bernard, Hugues, Gallacher, Matt J., Wyllie, Shylah D., Varrone, Georgianna, Cicia, Lisa A., Carsillo, Mary E., Fisher, Craig D., Ottinger, Sean E., Koenig, Erik, Kirby, Patrick J.

“…MicroRNAs (miRNA) are short single‐stranded RNA sequences that have a role in the post‐transcriptional regulation of genes. The identification of tissue…”
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Characterization of the Core Elements of the NF-κB Signaling Pathway of the Sea Anemone Nematostella vectensis by Wolenski, Francis S., Garbati, Michael R., Lubinski, Tristan J., Traylor-Knowles, Nikki, Dresselhaus, Erica, Stefanik, Derek J., Goucher, Haley, Finnerty, John R., Gilmore, Thomas D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Isolation of DNA, RNA and protein from the starlet sea anemone Nematostella vectensis by Stefanik, Derek J, Wolenski, Francis S, Friedman, Lauren E, Gilmore, Thomas D, Finnerty, John R

“…Among marine invertebrates, the starlet sea anemone Nematostella vectensis has emerged as an important laboratory model system. One advantage of working with…”
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Two Alleles of NF-κB in the Sea Anemone Nematostella vectensis Are Widely Dispersed in Nature and Encode Proteins with Distinct Activities by Sullivan, James C., Wolenski, Francis S., Reitzel, Adam M., French, Courtney E., Traylor-Knowles, Nikki, Gilmore, Thomas D., Finnerty, John R.

“…Background NF-κB is an evolutionarily conserved transcription factor that controls the expression of genes involved in many key organismal processes, including…”
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CYP Suppression in Human Hepatocytes by Monomethyl Auristatin E, the Payload in Brentuximab Vedotin (Adcetris®), is Associated with Microtubule Disruption by Wolenski, Francis S., Xia, Cindy Q., Ma, Bingli, Han, Tae H., Shyu, Wen C., Balani, Suresh K.

“…Background and Objectives Monomethyl auristatin E (MMAE), the toxin linked to CD30-specific monoclonal antibody of Adcetris ® (brentuximab vedotin), is a…”
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Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi by Csizmadia, Vilmos, Hales, Paul, Tsu, Christopher, Ma, Jingya, Chen, Jiejin, Shah, Pooja, Fleming, Paul, Senn, Joseph J, Kadambi, Vivek J, Dick, Larry, Wolenski, Francis S

“…The proteasome inhibitor bortezomib is associated with the development of peripheral neuropathy in patients, but the mechanism by which bortezomib can induce…”
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Two Polymorphic Residues Account for the Differences in DNA Binding and Transcriptional Activation by NF-κB Proteins Encoded by Naturally Occurring Alleles in Nematostella vectensis by Wolenski, Francis S., Chandani, Sushil, Stefanik, Derek J., Jiang, Ning, Chu, Emma, Finnerty, John R., Gilmore, Thomas D.

“…The NF-κB family of transcription factors is activated in response to many environmental and biological stresses, and plays a key role in innate immunity…”
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NF-κB: where did it come from and why?: NF-ĸB by GILMORE, Thomas D, WOLENSKI, Francis S

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Quantitative systems toxicology analysis of in vitro mechanistic assays reveals importance of bile acid accumulation in TAK-875-induced liver injury by Walker, Paul, Longo, Diane, Woodhead, Jeff, Siler, Scott, Watkins, Paul, Howell, Brett, Herédi-Szabó, Krisztina, Dragan, Yvonne, Wolenski, Francis, Mogyorosi, Karoly

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Abstract LB565: Efficacy of a highly potent and selective KIT V654A inhibitor for treatment of imatinib resistant GIST by Grassian, Alexandra R., Kim, Joseph, Ahmad, Omar, Barvian, Kevin, Davis, Alison, Dineen, Tom, Hu, Wei, Job, Ebby, Moine, Ludivine, Newberry, Kate, Roche, Maria, Shorten, Doug, Choi, Yeon Sook, Wolenski, Francis, Bauer, Sebastian, Serrano, Cesar, Trent, Jonathan, George, Suzanne

“…Gastrointestinal stromal tumor (GIST) is the most common type of sarcoma, with approximately 5,000 patients diagnosed per year in the US. Approximately 80% of…”
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NF-[kappa]B is required for cnidocyte development in the sea anemone Nematostella vectensis by Wolenski, Francis S, Bradham, Cynthia A, Finnerty, John R, Gilmore, Thomas D

“…The sea anemone Nematostella vectensis (Nv) is a leading model organism for the phylum Cnidaria, which includes anemones, corals, jellyfishes and hydras. A…”
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