Radionuclide Angiography with Technetium-99m In Vivo Labeled Erythrocytes Does Not Lead to Induction of Mutations in the HPRT Gene of Human T-Lymphocytes

Mutant frequencies were measured in T-lymphocytes of patients undergoing radionuclide angiography with erythrocytes labeled in vivo with technetium-99m. Blood from 13 patients was sampled before and after (8-120 days) an injection with 750 MBq technetium-99m. Frequencies of HPRT- mutants were measur...

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Bibliographic Details
Published in:	The Journal of nuclear medicine (1978) Vol. 32; no. 5; pp. 814 - 818
Main Authors:	van Dam, F.J, Camps, J.A, Woldring, V.M, Natarajan, A.T, van der Wall, E.E, Zwinderman, A.H, Lohman, P.H.M, Pauwels, E.K.J, Tates, A.D
Format:	Journal Article
Language:	English
Published:	Reston, VA Soc Nuclear Med 01-05-1991 Society of Nuclear Medicine
Subjects:	550601 - Medicine- Unsealed Radionuclides in Diagnostics 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man Adult Aged ANIMAL CELLS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS BIOMEDICAL RADIOGRAPHY BLOOD BLOOD CELLS BODY FLUIDS CLONING CONNECTIVE TISSUE CELLS DIAGNOSTIC TECHNIQUES ENZYMES ERYTHROCYTES Female Gated Blood-Pool Imaging GENE MUTATIONS GLYCOSYL TRANSFERASES HOURS LIVING RADIOISOTOPES Humans HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE Hypoxanthine Phosphoribosyltransferase - genetics INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES Investigative techniques, diagnostic techniques (general aspects) ISOMERIC NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES LABELLING LEUKOCYTES LYMPHOCYTES Male MATERIALS Medical sciences MEDICINE Middle Aged Mutation MUTATION FREQUENCY MUTATIONS NUCLEAR MEDICINE NUCLEI ODD-EVEN NUCLEI PATIENTS PENTOSYL TRANSFERASES Radiation Genetics RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOINDUCTION RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Radionuclide investigations SOMATIC CELLS T-Lymphocytes - radiation effects Technetium TECHNETIUM 99 TECHNETIUM ISOTOPES TRANSFERASES YEARS LIVING RADIOI Radionuclide study Human Angiography Toxicity T-Lymphocyte Cardiovascular disease Exploration Technetium Mutation
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Summary:	Mutant frequencies were measured in T-lymphocytes of patients undergoing radionuclide angiography with erythrocytes labeled in vivo with technetium-99m. Blood from 13 patients was sampled before and after (8-120 days) an injection with 750 MBq technetium-99m. Frequencies of HPRT- mutants were measured with the T-cell cloning method. Results indicated that the mean frequency of mutants after treatment was significantly below that measured before exposure. Thus, in contrast to published data, our results do not support the conclusion that radionuclide angiography with technetium-99m induces HPRT- mutations. Further analysis of our data indicated that the decrease in mutant frequency after exposure can be accounted for by an effect of cloning efficiency.
ISSN:	0161-5505 1535-5667