Modification of sodium, glucose, potassium, and osmolarity in packed red blood cells and fresh frozen plasma using a desktop hemoconcentrator setup

Massive transfusion with packed blood cells (PRBCs) or fresh frozen plasma (FFP) can result in dangerous complications including stroke, kidney failure, and cardiac arrest. A simple, bench top technique using a hemoconcentrator and dialysate solution is described to correct critical values of sodium...

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Bibliographic Details
Published in:	The Journal of extra-corporeal technology Vol. 44; no. 2; pp. 60 - 65
Main Authors:	Striker, Carrie Whittaker, Woldorf, Stacia, Holt, David
Format:	Journal Article
Language:	English
Published:	United States American Society of ExtraCorporeal Technology 01-06-2012
Subjects:	Equipment Safety Erythrocyte Transfusion - instrumentation Erythrocyte Transfusion - methods Erythrocytes - chemistry Glucose - analysis Health technology assessment Hemodialysis Solutions - chemistry Humans Osmolar Concentration Plasma - chemistry Plasma Exchange - instrumentation Plasma Exchange - methods Potassium - blood Sodium - blood Technique
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Summary:	Massive transfusion with packed blood cells (PRBCs) or fresh frozen plasma (FFP) can result in dangerous complications including stroke, kidney failure, and cardiac arrest. A simple, bench top technique using a hemoconcentrator and dialysate solution is described to correct critical values of sodium, glucose, potassium, and osmolarity in PRBCs and FFP. Sodium, glucose, and osmolarity were corrected to normal or near normal values. Elevated potassium was reduced by 65%, but not completely normalized. A simple, bench top method for correcting dangerous abnormalities with PRBCs and FFP can be used to improve the safety of massive blood transfusion.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Presented at the 48th International Conference of the American Society of ExtraCorporeal Technology, Reno, Nevada, April 28–May 1, 2010. The senior author has stated that authors have reported no material, financial, or other relationship with any healthcare-related business or other entity whose products or services are discussed in this paper.
ISSN:	0022-1058 2969-8960
DOI:	10.1051/ject/201244060