Epigenetic regulation in neurodevelopment and neurodegenerative diseases

Highlights ► The involvement of epigenetic processes in neurodevelopment. ► Their contribution to neurodegenerative diseases. ► Their study in animal models for diseases. ► The potential of epigenetic drugs for intervention.

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Bibliographic Details
Published in:	Neuroscience Vol. 264; pp. 99 - 111
Main Authors:	Gapp, K, Woldemichael, B.T, Bohacek, J, Mansuy, I.M
Format:	Journal Article
Language:	English
Published:	United States 04-04-2014
Subjects:	Animals Brain - growth & development Chromatin Assembly and Disassembly Epigenesis, Genetic Humans Neurodegenerative Diseases - genetics Neurology Neurons - physiology DNMTs APP HDACs histone demethylases HMTs TNF-alpha embryonic stem cells DNA methyltransferases epigenetics CBP CREB-binding protein histone methyl transferases tumor necrosis factor alpha neurodevelopment amyloid precursor protein histone deacetylases Huntington’s disease ESCs CpG islands AD HDMs Alzheimer’s disease CGI neural stem cells neuron-restrictive silencer factor SNpc imprinting disorders GFAP histone acetyl transferases PTMs NSCs substantia nigra pars compacta NRSF posttranslational modifications PD HATs HD glial fibrillary acidic protein Parkinson’s disease
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Summary:	Highlights ► The involvement of epigenetic processes in neurodevelopment. ► Their contribution to neurodegenerative diseases. ► Their study in animal models for diseases. ► The potential of epigenetic drugs for intervention.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.11.040