Search Results - "Wolberg, A. S."

Plasma and cellular contributions to fibrin network formation, structure and stability by WOLBERG, A. S.

“…Growing evidence suggests that fibrin network structure and stability are important determinants of haemostasis and thrombosis, with alterations in fibrin…”
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Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH by Dargaud, Y., Wolberg, A. S., Gray, E., Negrier, C., Hemker, H. C.

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Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system by Allen, G. A., Wolberg, A. S., Oliver, J. A., Hoffman, M., Roberts, H. R., Monroe, D. M.

“…Using a cell‐based model system of coagulation, we performed a systematic examination of the effect of varying individual procoagulant proteins (over the range…”
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Murine models do not recapitulate the pathophysiology of age‐related venous thrombosis in humans by Cardenas, J. C., Aleman, M. M., Wang, J.‐G., Whinna, H. C., Wolberg, A. S., Church, F. C.

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Fibrinogen, red blood cells, and factor XIII in venous thrombosis by Walton, B. L., Byrnes, J. R., Wolberg, A. S.

“…Summary Cardiovascular disease is the leading cause of death and disability worldwide. Among cardiovascular causes of death, venous thrombosis (VT) is ranked…”
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Abnormal plasma clot structure and stability distinguish bleeding risk in patients with severe factor XI deficiency by Zucker, M., Seligsohn, U., Salomon, O., Wolberg, A. S.

“…Summary Background Factor XI (FXI) deficiency is a rare autosomal recessive disorder. Many patients with even very low FXI levels (< 20 IU dL−1) are…”
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Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia by Sauls, D. L., Wolberg, A. S., Hoffman, M.

“…Elevated plasma homocysteine is associated with an increased risk of atherosclerosis and thrombosis. However, the mechanisms by which homocysteine might cause…”
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Tissue factor–positive tumor microvesicles activate platelets and enhance thrombosis in mice by Geddings, J. E., Hisada, Y., Boulaftali, Y., Getz, T. M., Whelihan, M., Fuentes, R., Dee, R., Cooley, B. C., Key, N. S., Wolberg, A. S., Bergmeier, W., Mackman, N.

“…Essentials Cancer patients have a high rate of venous thrombosis (VT) but the underlying mechanisms are unknown. Tumor‐derived, tissue factor‐positive…”
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Differential contributions of monocyte‐ and platelet‐derived microparticles towards thrombin generation and fibrin formation and stability by ALEMAN, M. M., GARDINER, C., HARRISON, P., WOLBERG, A. S.

“…Background: Microparticles (MPs) are sub‐micron vesicles shed by activated or apoptotic cells, including platelets and monocytes. Increased circulating MPs are…”
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Analyzing fibrin clot structure using a microplate reader by Wolberg, A S, Gabriel, D A, Hoffman, M

“…Fibrin clot structure studies are often performed using optical methods. For example, the clot's fiber structure can be assessed by measuring light scattering…”
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Factor XIII cotreatment with hemostatic agents in hemophilia A increases fibrin α‐chain crosslinking by Beckman, J. D., Holle, L. A., Wolberg, A. S.

“…Essentials Factor XIII (FXIII)‐mediated fibrin crosslinking is delayed in hemophilia. We determined effects of FXIII cotreatment with hemostatic agents on clot…”
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Tissue factor de-encryption: ionophore treatment induces changes in tissue factor activity by phosphatidylserine-dependent and -independent mechanisms by Wolberg, A S, Monroe, D M, Roberts, H R, Hoffman, M R

“…Coagulation is initiated on tissue-factor-bearing cells when factor VIIa complexes with membrane-bound tissue factor and activates factors X and IX. Cellular…”
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Air pollution upregulates endothelial cell procoagulant activity via ultrafine particle-induced oxidant signaling and tissue factor expression by Snow, S J, Cheng, W, Wolberg, A S, Carraway, M S

“…Air pollution exposure is associated with cardiovascular events triggered by clot formation. Endothelial activation and initiation of coagulation are…”
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Recombinant porcine factor VIII for high‐risk surgery in paediatric congenital haemophilia A with high‐titre inhibitor by Croteau, S. E., Abajas, Y. L., Wolberg, A. S., Nielsen, B. I., Marx, G. R., Baird, C. W., Neufeld, E. J., Monahan, P. E.

“…Introduction High‐titre factor VIII (FVIII) inhibitors complicate peri‐operative haemostasis. Recombinant porcine FVIII (r‐pFVIII) may provide an alternative…”
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The fibrinogen γA/γ′ isoform does not promote acute arterial thrombosis in mice by Walton, B. L., Getz, T. M., Bergmeier, W., Lin, F.‐C., Uitte de Willige, S., Wolberg, A. S.

“…Summary Background Elevated plasma fibrinogen is associated with arterial thrombosis in humans and promotes thrombosis in mice by increasing fibrin formation…”
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Plasma clot properties in patients with a mild-to-moderate bleeding tendency of unknown cause by Gebhart, J., Laczkovics, C., Posch, F., Ay, C., Reitter-Pfoertner, S. E., Haslacher, H., Muszbek, L., Wolberg, A. S., Pabinger, I.

“…In a large proportion of patients with mild bleeding disorders (MBDs) no diagnosis can be established by routine coagulation tests. We investigated whether…”
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MONITORING FIBRINOLYSIS WITH GLOBAL ASSAYS TO DETECT HYPER AND HYPOFIBRINOLYSIS PHENOTYPES by SAL Montalvao, Y Sang, S Reitsma, L Arzenares, MC Fernandes, BM Martinelli, LQ Silva, EV Paula, JM Annichino-Bizzacchi, AS Wolberg

“…Introduction: The fibrinolytic system is an important component of hemostasis that acts as a balance of blood coagulation to protect the vasculature from…”
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Deencryption of Cellular Tissue Factor Is Independent of Its Cytoplasmic Domain by Wolberg, A.S., Kon, R.H., Monroe, D.M., Ezban, M., Roberts, H.R., Hoffman, M.

“…Tissue factor (TF) is a transmembrane molecule that, when exposed to plasma, is the key initiator of coagulation. Cellular TF activity is normally “encrypted”,…”
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Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet by LI, F., WANG, C.‐H., WANG, J.‐G., THAI, T., BOYSEN, G., XU, L., TURNER, A. L., WOLBERG, A. S., MACKMAN, N., MAEDA, N., TAKAHASHI, N.

“…Background: Human eNOS (NOS3) polymorphisms that lower its expression are associated with advanced diabetic nephropathy (DN), and the lack of eNOS accelerates…”
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Enhanced cell‐associated plasminogen activator pathway but not coagulation pathway activity contributes to motility in metastatic breast cancer cells by CARTER, J. C., CAMPBELL, R. A., GIBBONS, J. A., GRAMLING, M. W., WOLBERG, A. S., CHURCH, F. C.

“…Background: Activation of tumor cell‐associated coagulation and plasminogen activator pathways occurs in malignant disease processes, including breast cancer,…”
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