Search Results - "Wolak, Daniel J"

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery by Wolak, Daniel J, Thorne, Robert G

“…Therapeutics must diffuse through the brain extracellular space (ECS) in order to distribute within the central nervous system (CNS) compartment; this…”
Get full text

Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration by Lochhead, Jeffrey J, Wolak, Daniel J, Pizzo, Michelle E, Thorne, Robert G

“…The intranasal administration route is increasingly being used as a noninvasive method to bypass the blood—brain barrier because evidence suggests small…”
Get full text

Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery by Pizzo, Michelle E., Wolak, Daniel J., Kumar, Niyanta N., Brunette, Eric, Brunnquell, Christina L., Hannocks, Melanie‐Jane, Abbott, N. Joan, Meyerand, M. Elizabeth, Sorokin, Lydia, Stanimirovic, Danica B., Thorne, Robert G.

“…Key points It is unclear precisely how macromolecules (e.g. endogenous proteins and exogenous immunotherapeutics) access brain tissue from the cerebrospinal…”
Get full text

Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery by Kumar, Niyanta N., Gautam, Mohan, Lochhead, Jeffrey J., Wolak, Daniel J., Ithapu, Vamsi, Singh, Vikas, Thorne, Robert G.

“…Intranasal administration provides a non-invasive drug delivery route that has been proposed to target macromolecules either to the brain via direct…”
Get full text

Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging by Wolak, Daniel J, Pizzo, Michelle E, Thorne, Robert G

“…Antibody-based therapeutics exhibit great promise in the treatment of central nervous system (CNS) disorders given their unique customizable properties…”
Get full text

Distribution of Biologics within the Brain Microenvironment: Focus on Antibodies and Adeno-Associated Viral Vectors by Wolak, Daniel J

“…This dissertation investigated the diffusion and distribution of antibody-based therapeutics and viral vectors within the brain extracellular space. We…”
Get full text