Search Results - "Wojtowicz, Edyta"

You are what you eat: How to best fuel your immune system by Hellmich, Charlotte, Wojtowicz, Edyta E

“…Normal bone marrow (BM) homeostasis ensures consistent production of progenitor cells and mature blood cells. This requires a reliable supply of nutrients in…”
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ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection by Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W., Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J., Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.

“…Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC…”
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LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation by Moore, Jamie A, Mistry, Jayna J, Hellmich, Charlotte, Horton, Rebecca H, Wojtowicz, Edyta E, Jibril, Aisha, Jefferson, Matthew, Wileman, Thomas, Beraza, Naiara, Bowles, Kristian M, Rushworth, Stuart A

“…The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell…”
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Acute myeloid leukemia-driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias by Fowler-Shorten, Dominic J, Maynard, Rebecca S, Hampton, Katherine, Altera, Annalisa, Markham, Matthew, Ehikioya, Martha, Wojtowicz, Edyta E, Bowles, Kristian M, Rushworth, Stuart A, Hellmich, Charlotte

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Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression by Jibril, Aisha, Hellmich, Charlotte, Wojtowicz, Edyta E., Hampton, Katherine, Maynard, Rebecca, De Silva, Ravindu, Fowler-Shorten, Dominic J., Mistry, Jayna J., Moore, Jamie A., Bowles, Kristian M., Rushworth, Stuart A.

“…•Cell-free mtDNA is elevated in the peripheral blood and BM of patients with myeloma compared with those of healthy controls.•Myeloma-derived mtDNA remodels…”
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microRNAs in hematopoiesis by Lazare, Seka S., Wojtowicz, Edyta E., Bystrykh, Leonid V., de Haan, Gerald

“…miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into…”
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Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors by Wojtowicz, Edyta E., Lechman, Eric R., Hermans, Karin G., Schoof, Erwin M., Wienholds, Erno, Isserlin, Ruth, van Veelen, Peter A., Broekhuis, Mathilde J.C., Janssen, George M.C., Trotman-Grant, Aaron, Dobson, Stephanie M., Krivdova, Gabriela, Elzinga, Jantje, Kennedy, James, Gan, Olga I., Sinha, Ankit, Ignatchenko, Vladimir, Kislinger, Thomas, Dethmers-Ausema, Bertien, Weersing, Ellen, Alemdehy, Mir Farshid, de Looper, Hans W.J., Bader, Gary D., Ritsema, Martha, Erkeland, Stefan J., Bystrykh, Leonid V., Dick, John E., de Haan, Gerald

“…Umbilical cord blood (CB) is a convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However,…”
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Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages by Wojtowicz, Edyta E., Hampton, Katherine, Moreno-Gonzalez, Mar, Utting, Charlotte L., Lan, Yuxuan, Ruiz, Paula, Beasy, Gemma, Bone, Caitlin, Hellmich, Charlotte, Maynard, Rebecca, Acton, Luke, Markham, Matthew, Troeberg, Linda, Telatin, Andrea, Kingsley, Robert A., Macaulay, Iain C., Rushworth, Stuart A., Beraza, Naiara

“…Western diets are the underlying cause of metabolic and liver diseases. Recent trend to limit the consumption of protein-rich animal products has become more…”
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MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis by Wojtowicz, Edyta E, Walasek, Marta A, Broekhuis, Mathilde J.C, Weersing, Ellen, Ritsema, Martha, Ausema, Albertina, Bystrykh, Leonid V, de Haan, Gerald

“…MicroRNAs (miRNAs) are crucial for proper functioning of hematopoietic stem and progenitor cells (HSPCs). Members of the miRNA-125 family (consisting of…”
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Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion by Wojtowicz, Edyta E, Mistry, Jayna J, Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W, Kettyle, Laura M, Grasso, Francesca, Lord, Allegra M, Wright, David J, Etherington, Graham J, Woll, Petter S, Belderbos, Mirjam E, Bowles, Kristian M, Nerlov, Claus, Haerty, Wilfried, Bystrykh, Leonid V, Jacobsen, Sten Eirik W, Rushworth, Stuart A, Macaulay, Iain C

“…Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages…”
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B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice by Chu, Yuanyuan, Vahl, J. Christoph, Kumar, Dilip, Heger, Klaus, Bertossi, Arianna, Wójtowicz, Edyta, Soberon, Valeria, Schenten, Dominik, Mack, Brigitte, Reutelshöfer, Miriam, Beyaert, Rudi, Amann, Kerstin, van Loo, Geert, Schmidt-Supprian, Marc

“…The ubiquitin-editing enzyme A20/TNFAIP3 is essential for controlling signals inducing the activation of nuclear factor-κB transcription factors. Polymorphisms…”
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The Aging Bone Marrow Niche Disrupts Glutamine Metabolism By Upregulating HSC Derived Glutamine Synthetase by Hellmich, Charlotte, Wojtowicz, Edyta E, Fowler-Shorten, Dominic, Maynard, Rebecca S, Hampton, Katherine, Macaulay, Iain, Bowles, Kristian, Rushworth, Stuart

“…As our aging population grows it is becoming increasingly important to better understand the physiological changes that drive that drive the aging process…”
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Acute Myeloid Leukemia Driven IL-3 Dependent Upregulation of BCL-2 in Non-Malignant Hematopoietic Progenitor Cells Increases Venetoclax Induced Cytopenias by Fowler-Shorten, Dominic, Maynard, Rebecca S, Hampton, Katherine, Ehikioya, Martha, Wojtowicz, Edyta E, Bowles, Kristian, Rushworth, Stuart, Hellmich, Charlotte

“…The BH3 mimetic venetoclax, in combination with low dose cytarabine, decitabine or azacitidine has shown clinical efficacy in newly diagnosed acute myeloid…”
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3185 – FROM STEM CELL TO MEGAKARYOCYTE: DELINEATING LINEAGE COMMITMENT IN MURINE MEGAKARYOPOIESIS USING SINGLE-CELL RNA-SEQ by Scoones, Anita, Wojtowicz, Edyta, Madgwick, Matthew, Rushworth, Stuart, Haerty, Wilfried, Macaulay, Iain

“…Technological advances in single-cell ‘omics’ such as high-throughput scRNAseq has enabled the discovery of novel cell types and states in the hematopoietic…”
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Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals by Hellmich, Charlotte, Wojtowicz, Edyta, Maynard, Rebecca S, Hampton, Katherine, Mistry, Jayna J, Moore, Jamie A, Jibril, Aisha, Utting, Charlotte L, Macauley, Iain, Bowles, Kristian M, Rushworth, Stuart A

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BCL-Xl Driven Accumulation of Dysfunctional Mitochondria in Aged Stromal Cells Impairs the Haematopoietic Stem Cell Response to Stress by Hellmich, Charlotte, Mistry, Jayna J, Jibril, Aisha, Moore, Jamie A, Johnson, Benjamin B, Smith, James G W, Wojtowicz, Edyta, Beraza, Naiara, Bowles, Kristian M, Rushworth, Stuart A

“…The burden of infections is known to increase with age. Not only is ageing associated with greater susceptibility to infections but also an increase in…”
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LC3-Associated Phagocytosis in Bone Marrow Macrophages Suppresses AML Progression through Mitochondrial DAMP Induced Sting Activation by Moore, Jamie A, Mistry, Jayna J, Hellmich, Charlotte, Horton, Rebecca H, Wojtowicz, Edyta, Jibril, Aisha, Wileman, Tom, Jefferson, Matthew, Beraza, Naiara, Bowles, Kristian M, Rushworth, Stuart A

“…The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation and chemotherapy resistance. Following cancer cell…”
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Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression by Jibril, Aisha, Hellmich, Charlotte, Wojtowicz, Edyta, Hampton, Katherine, Maynard, Rebecca S, De Silva, Ravindu, Fowler-Shorten, Dominic J, Mistry, Jayna J., Moore, Jamie A, Bowles, Kristian M, Rushworth, Stuart A

“…Mitochondrial damage-associated molecular patterns (mtDAMPs) include proteins, lipids, metabolites and DNA and have various context specific immunoregulatory…”
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3227 – PARALLEL CLONAL AND MOLECULAR PROFILING OF HEMATOPOIETIC STEM CELLS USING RNA BARCODING by wojtowicz, edyta, Mistry, Jayna, Uzun, Vladimir, Scoones, Anita, Chin, Desmond, Kettyle, Laura, Lord, Allegra, Grasso, Francesca, Etherington, Graham, Hellmich, Charlotte, Woll, Petter, Belderbos, Mirjam, Bowles, Kristian, Bystrykh, Leonid, Nerlov, Claus, Haerty, Wilfried, Jacobsen, Sten Eirik, Rushworth, Stuart, Macaulay, Iain

“…Anucleate cells - platelets and erythrocytes - constitute over 95% of all hematopoietic stem cell (HSC) output, but the clonal dynamics of HSC contribution to…”
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MiR-125a enhances self-renewal, lifespan, and migration of murine hematopoietic stem and progenitor cell clones by Wojtowicz, Edyta Ewa, Broekhuis, Mathilde Johanna Christina, Weersing, Ellen, Dinitzen, Alexander, Verovskaya, Evgenia, Ausema, Albertina, Ritsema, Martha, Zwart, Erik, de Haan, Gerald, Bystrykh, Leonid V.

“…Expansion of hematopoietic stem cells (HSCs) is a ‘holy grail’ of regenerative medicine, as successful stem cell transplantations depend on the number and…”
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