Search Results - "Wojtczak, Błażej A"

Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity by Pastwińska, Joanna, Karaś, Kaja, Sałkowska, Anna, Karwaciak, Iwona, Chałaśkiewicz, Katarzyna, Wojtczak, Błażej A, Bachorz, Rafał A, Ratajewski, Marcin

“…RORγT is a protein product of the RORC gene belonging to the nuclear receptor subfamily of retinoic-acid-receptor-related orphan receptors (RORs). RORγT is…”
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Versatile Method for the Site‐Specific Modification of DNA with Boron Clusters: Anti‐Epidermal Growth Factor Receptor (EGFR) Antisense Oligonucleotide Case by Ebenryter‐Olbińska, Katarzyna, Kaniowski, Damian, Sobczak, Milena, Wojtczak, Błażej A, Janczak, Sławomir, Wielgus, Ewelina, Nawrot, Barbara, Leśnikowski, Zbigniew J

“…A general and convenient approach for the incorporation of different types of boron clusters into specific locations of the DNA‐oligonucleotide chain based on…”
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"Chemical Ligation": A Versatile Method for Nucleoside Modification with Boron Clusters by Wojtczak, Błazej A., Andrysiak, Agnieszka, Grüner, Bohumír, Lesnikowski, Zbigniew J.

“…A general approach to the synthesis of nucleoside conjugates containing carborane and metallocarborane complexes, based on Huisgen 1,3‐dipolar cycloaddition…”
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N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins by Kopcial, Michal, Wojtczak, Blazej A, Kasprzyk, Renata, Kowalska, Joanna, Jemielity, Jacek

“…The mRNA 5' cap consists of N7-methylguanosine bound by a 5',5'-triphosphate bridge to the first nucleotide of the transcript. The cap interacts with various…”
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Adenosine and 2′-Deoxyadenosine Modified with Boron Cluster Pharmacophores as New Classes of Human Blood Platelet Function Modulators by Bednarska, Katarzyna, Olejniczak, Agnieszka B., Wojtczak, Błażej A., Sułowska, Zofia, Leśnikowski, Zbigniew J.

“…Novel types of adenosine and 2′‐deoxyadenosine derivatives containing boron clusters at positions C2′, N6, or C8 were synthesized. The effect of these modified…”
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5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes by Wojtczak, Blazej A, Sikorski, Pawel J, Fac-Dabrowska, Kaja, Nowicka, Anna, Warminski, Marcin, Kubacka, Dorota, Nowak, Elzbieta, Nowotny, Marcin, Kowalska, Joanna, Jemielity, Jacek

“…The 5′ cap consists of 7-methyl­guanosine (m7G) linked by a 5′–5′-triphosphate bridge to messenger RNA (mRNA) and acts as the master regulator of mRNA turnover…”
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Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki–Miyaura Cross-Coupling: Discovery of 7‑Methylguanosine-Based Molecular Rotors by Wojtczak, Blazej A., Bednarczyk, Marcelina, Sikorski, Pawel J., Wojtczak, Anna, Surynt, Piotr, Kowalska, Joanna, Jemielity, Jacek

“…Chemical modifications of the mRNA cap structure can enhance the stability, translational properties, and half-life of mRNAs, thereby altering the therapeutic…”
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Ethynyl, 2‑Propynyl, and 3‑Butynyl C‑Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC by Wanat, Przemyslaw, Walczak, Sylwia, Wojtczak, Blazej A, Nowakowska, Monika, Jemielity, Jacek, Kowalska, Joanna

“…The synthesis and reactivity of a novel class of clickable nucleotide analogues containing a C-phosphonate subunit that has an alkyne group at the terminal…”
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7-Methylguanosine monophosphate analogues with 5′-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase by Kozarski, Mateusz, Kubacka, Dorota, Wojtczak, Blazej A., Kasprzyk, Renata, Baranowski, Marek R., Kowalska, Joanna

“…[Display omitted] The hydrolysis of nucleoside 5′-monophosphates to the corresponding nucleosides and inorganic phosphate is catalysed by 5′-nucleotidases,…”
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Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies by Baranowski, Marek R, Nowicka, Anna, Rydzik, Anna M, Warminski, Marcin, Kasprzyk, Renata, Wojtczak, Blazej A, Wojcik, Jacek, Claridge, Timothy D. W, Kowalska, Joanna, Jemielity, Jacek

“…To broaden the scope of existing methods based on 19F nucleotide labeling, we developed a new method for the synthesis of fluorophosphate (oligo)­nucleotide…”
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Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5',5'-triphosphate bridge by Zytek, Malgorzata, Kowalska, Joanna, Lukaszewicz, Maciej, Wojtczak, Blazej A, Zuberek, Joanna, Ferenc-Mrozek, Aleksandra, Darzynkiewicz, Edward, Niedzwiecka, Anna, Jemielity, Jacek

“…A trimethylguanosine (TMG) cap is present at the 5' end of several small nuclear and nucleolar RNAs. Recently, it has been reported that the TMG cap is a…”
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Phosphorylation of Nucleoside-Metallacarborane and Carborane Conjugates by Nucleoside Kinases by Wojtczak, Blazej A., Olejniczak, Agnieszka B., Wang, Liya, Eriksson, Staffan, Lesnikowski, Zbigniew J.

“…A library of purine and pyrimidine nucleosides modified with carborane or metallacarborane boron clusters at different locations, consisting of new molecules…”
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Nucleoside modification with boron clusters and their metal complexes by Wojtczak, Blazej A, Olejniczak, Agnieszka B, Lesnikowski, Zbigniew J

“…General methods for the synthesis of nucleosides modified with borane clusters and metallacarborane complexes are presented. These include: (1) the click…”
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Highly Lipophilic p-Carborane-Modified Adenosine Phosphates by Wojtczak, Blazej A., Olejniczak, Agnieszka B., Przepiórkiewicz, Marzena, Andrysiak, Agnieszka, Lesnikowski, Zbigniew J.

“…The method was developed for the synthesis of biologically important adenosine phosphates, AMP, cAMP and ATP modified with p -carborane cluster - a highly…”
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Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19 F NMR Studies by Baranowski, Marek R., Nowicka, Anna, Rydzik, Anna M., Warminski, Marcin, Kasprzyk, Renata, Wojtczak, Blazej A., Wojcik, Jacek, Claridge, Timothy D. W., Kowalska, Joanna, Jemielity, Jacek

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