Search Results - "Wojtaszewski, J."

Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training by Deshmukh, A. S., Steenberg, D. E., Hostrup, M., Birk, J. B., Larsen, J. K., Santos, A., Kjøbsted, R., Hingst, J. R., Schéele, C. C., Murgia, M., Kiens, B., Richter, E. A., Mann, M., Wojtaszewski, J. F. P.

“…Skeletal muscle conveys several of the health-promoting effects of exercise; yet the underlying mechanisms are not fully elucidated. Studying skeletal muscle…”
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Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle by Birk, J. B., Wojtaszewski, J. F. P.

“…5′AMP‐activated protein kinase (AMPK) is a key regulator of cellular metabolism and is regulated in muscle during exercise. We have previously established that…”
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Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training by Vind, B. F, Pehmøller, C, Treebak, J. T, Birk, J. B, Hey-Mogensen, M, Beck-Nielsen, H, Zierath, J. R, Wojtaszewski, J. F. P, Højlund, K

“…Aims/hypothesis Insulin-mediated glucose disposal rates (R d) are reduced in type 2 diabetic patients, a process in which intrinsic signalling defects are…”
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Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle by Treebak, J. T, Frøsig, C, Pehmøller, C, Chen, S, Maarbjerg, S. J, Brandt, N, MacKintosh, C, Zierath, J. R, Hardie, D. G, Kiens, B, Richter, E. A, Pilegaard, H, Wojtaszewski, J. F. P

“…Aims/hypothesis TBC1 domain family, member 4 (TBC1D4; also known as AS160) is a cellular signalling intermediate to glucose transport regulated by…”
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Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes by Vind, B. F., Birk, J. B., Vienberg, S. G., Andersen, B., Beck-Nielsen, H., Wojtaszewski, J. F. P., Højlund, K.

“…Aims/hypothesis In type 2 diabetes, reduced insulin-stimulated glucose disposal, primarily glycogen synthesis, is associated with defective insulin activation…”
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Author Correction: Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training by Deshmukh, A. S., Steenberg, D. E., Hostrup, M., Birk, J. B., Larsen, J. K., Santos, A., Kjøbsted, R., Hingst, J. R., Schéele, C. C., Murgia, M., Kiens, B., Richter, E. A., Mann, M., Wojtaszewski, J. F. P.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22015-4…”
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AMP-activated protein kinase in contraction regulation of skeletal muscle metabolism: necessary and/or sufficient? by Jensen, T.E, Wojtaszewski, J.F.P, Richter, E.A

“…In skeletal muscle, the contraction-activated heterotrimeric 5'-AMP-activated protein kinase (AMPK) protein is proposed to regulate the balance between…”
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The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate‐intensity exercise in human skeletal muscle by Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A. B., Prats, C., Greenhaff, P. L., Constantin‐Teodosiu, D., Birk, J. B., Wojtaszewski, J. F. P., Dela, F., Helge, J. W.

“…Key points This study aimed to provide molecular insight into the differential effects of age and physical inactivity on the regulation of substrate metabolism…”
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Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise by Vendelbo, M H, Møller, A B, Treebak, J T, Gormsen, L C, Goodyear, L J, Wojtaszewski, J F P, Jørgensen, J O L, Møller, N, Jessen, N

“…phosphorylation of AS160 and TBC1D1 plays an important role for GLUT4 mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in…”
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IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice by Brandt, C., Jakobsen, A. H., Adser, H., Olesen, J., Iversen, N., Kristensen, J. M., Hojman, P., Wojtaszewski, J. F. P., Hidalgo, J., Pilegaard, H.

“…Aim:  The aim of this study was to test the hypothesis that IL‐6 regulates exercise‐induced gene responses in subcutaneous adipose tissue in mice. Methods: …”
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A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase by Maile, C.A., Hingst, J.R., Mahalingan, K.K., O'Reilly, A.O., Cleasby, M.E., Mickelson, J.R., McCue, M.E., Anderson, S.M., Hurley, T.D., Wojtaszewski, J.F.P., Piercy, R.J.

“…Equine type 1 polysaccharide storage myopathy (PSSM1) is associated with a missense mutation (R309H) in the glycogen synthase (GYS1) gene, enhanced glycogen…”
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A common variation of the PTEN gene is associated with peripheral insulin resistance by Grinder-Hansen, L, Ribel-Madsen, R, Wojtaszewski, J.F.P, Poulsen, P, Grunnet, L.G, Vaag, A

“…Abstract Aim Phosphatase and tensin homologue (PTEN) reduces insulin sensitivity by inhibiting the phosphatidylinositol 3-kinase (PI3K)/v-akt murine thymoma…”
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Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle by Vendelbo, M H, Clasen, B F F, Treebak, J T, Møller, L, Krusenstjerna-Hafstrøm, T, Madsen, M, Nielsen, T S, Stødkilde-Jørgensen, H, Pedersen, S B, Jørgensen, J O L, Goodyear, L J, Wojtaszewski, J F P, Møller, N, Jessen, N

“…During fasting, human skeletal muscle depends on lipid oxidation for its energy substrate metabolism. This is associated with the development of insulin…”
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Reduced plasma adiponectin concentrations may contribute to impaired insulin activation of glycogen synthase in skeletal muscle of patients with type 2 diabetes by HØJLUND, K, FRYSTYK, J, LEVIN, K, FLYVBJERG, A, WOJTASZEWSKI, J. F. P, BECK-NIELSEN, H

“…Circulating levels of adiponectin are negatively associated with multiple indices of insulin resistance, and the concentration is reduced in humans with…”
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Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery by Leick, L., Plomgaard, P., Grønløkke, L., Al-Abaiji, F., Wojtaszewski, J. F. P., Pilegaard, H.

“…Exercise‐induced adaptations in skeletal muscle oxidative enzymes are suggested to result from the cumulative effects of transient changes in gene expression…”
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Differential aetiology and impact of phosphoinositide 3-kinase (PI3K) and Akt signalling in skeletal muscle on in vivo insulin action by Friedrichsen, M, Poulsen, P, Richter, E. A, Hansen, B. F, Birk, J. B, Ribel-Madsen, R, Stender-Petersen, K, Nilsson, E, Beck-Nielsen, H, Vaag, A, Wojtaszewski, J. F. P

“…Aims/hypothesis Insulin resistance in skeletal muscle is a key factor in the development of type 2 diabetes and although some studies indicate that this could…”
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Interleukin-6 modifies mRNA expression in mouse skeletal muscle by Adser, H., Wojtaszewski, J. F. P., Jakobsen, A. H., Kiilerich, K., Hidalgo, J., Pilegaard, H.

“…Aim:  The aim of this study was to test the hypothesis that interleukin (IL)‐6 plays a role in exercise‐induced peroxisome proliferator‐activated receptor γ…”
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Skeletal muscle mitochondrial respiration in AMPKα2 kinase-dead mice by Larsen, S., Kristensen, J. M., Stride, N., Wojtaszewski, J. F. P., Helge, J. W., Dela, F.

“…Aim: To study whether the phenotypical characteristics (exercise intolerance; reduced spontaneous activity) of the AMPKα2 kinase‐dead (KD) mice can be…”
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Role of 5′AMP-activated protein kinase in skeletal muscle by Treebak, J T, Wojtaszewski, J F P

“…5′AMP-activated protein kinase (AMPK) is recognized as an important intracellular energy sensor, shutting down energy-consuming processes and turning on…”
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AMP-activated protein kinase in Sickness and Health - From Molecule to Man by Wojtaszewski, J. F. P.

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