Search Results - "Wojtala, Martyna"
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Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States
Published in Nutrients (17-03-2020)“…Ketone bodies (KBs), comprising β-hydroxybutyrate, acetoacetate and acetone, are a set of fuel molecules serving as an alternative energy source to glucose…”
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Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule
Published in Scientific reports (24-01-2019)“…Butyrate and R-β-hydroxybutyrate are two related short chain fatty acids naturally found in mammals. Butyrate, produced by enteric butyric bacteria, is present…”
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The Role of Lysine-Specific Demethylase 1 (LSD1) in Shaping the Endothelial Inflammatory Response
Published in Cellular physiology and biochemistry (06-10-2021)“…Inflammation is the body's natural response to stress in the broadest sense. The regulatory mechanisms that control this process, some of which are still…”
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Piceatannol effectively counteracts glyceraldehyde-3-phosphate dehydrogenase aggregation and nuclear translocation in hippocampal cells
Published in Journal of functional foods (01-07-2019)“…[Display omitted] •Piceatannol significantly abolishes GAPDH nuclear translocation.•Piceatannol exerts anti-aggregation activity.•Piceatannol enhances catalase…”
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Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells
Published in Cells (Basel, Switzerland) (07-10-2019)“…The methylation of histone lysine residues modifies chromatin conformation and regulates the expression of genes implicated in cell metabolism. Lysine-specific…”
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Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics
Published in BioFactors (Oxford) (01-01-2017)“…Rather than being a passive barrier between circulating blood and smooth muscle cells and the underlying tissues, the endothelium is a fundamental functional…”
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Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells
Published in Pharmacological research (01-02-2018)“…[Display omitted] Epigenetic mechanisms, including histone post-translational modifications, are central regulators of cell cycle control. The euchromatic G9a…”
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Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells
Published in Journal of bioenergetics and biomembranes (01-02-2016)“…Novel approaches to cancer chemotherapy employ metabolic differences between normal and tumor cells, including the high dependence of cancer cells on…”
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Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells
Published in Biochemical pharmacology (01-12-2016)“…[Display omitted] Posttranslational modifications of histone tails can alter chromatin structure and regulate gene transcription. While recent studies…”
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