Search Results - "Wojczynski, M K"

PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study by Graff, M, North, K E, Franceschini, N, Reiner, A P, Feitosa, M, Carr, J J, Gordon-Larsen, P, Wojczynski, M K, Borecki, I B

“…BACKGROUND: Fatty liver disease (FLD) is characterized by increased intrahepatic triglyceride content with or without inflammation and is associated with…”
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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption by Cornelis, M C, Byrne, E M, Esko, T, Nalls, M A, Paynter, N, Monda, K L, Amin, N, Renstrom, F, Cavadino, A, Nolte, I M, Teumer, A, Yu, K, Manichaikul, A, Wojczynski, M K, Vink, J M, Zhao, J H, Burlutsky, G, Lahti, J, Lemaitre, R N, Eriksson, J, Musani, S K, Tanaka, T, Luan, J, Hui, J, Ho, W-K, Magnusson, P K E, Pedersen, N L, Couper, D, Oostra, B A, Tiemeier, H W, Uitterlinden, A G, Barroso, I, Xue, L, Kaakinen, M, Milani, L, Power, C, Baumeister, S E, Biffar, R, Kutalik, Z, Jacobs, D R, Lind, L, Jensen, M, Luben, R N, Wang, J J, Männistö, S, Lehtimäki, T, Viikari, J, Mozaffarian, D, Mukamal, K, Döring, A, Montgomery, G W, Dahmen, N, Tucker, K L, Ferrucci, L, Treur, J L, Mellström, D, Hottenga, J J, Tönjes, A, Deloukas, P, Kanoni, S, Lorentzon, M, Houston, D K, Liu, Y, Mason, M A, Zonderman, A B, Franke, L, Kristal, B S, Karjalainen, J, Reed, D R, Westra, H-J, Evans, M K, Dedoussis, G, Stumvoll, M, Bandinelli, S, Ordovas, J M, Chan, A T, Ohlsson, C, Gieger, C, Martin, N G, Siscovick, D S, Raitakari, O, Eriksson, J G, Mitchell, P, Hunter, D J, Rimm, E B, Borecki, I B, Vollenweider, P, Grabe, H J, Neuhouser, M L, Wolffenbuttel, B H R, Hyppönen, E, Cupples, L A, Franks, P W, van Duijn, C M, Heiss, G, Metspalu, A, North, K E, Ingelsson, E, Nettleton, J A, van Dam, R M

“…Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health…”
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Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies by Smith, C E, Ngwa, J, Tanaka, T, Qi, Q, Wojczynski, M K, Lemaitre, R N, Anderson, J S, Manichaikul, A, Mikkilä, V, van Rooij, F J A, Ye, Z, Bandinelli, S, Frazier-Wood, A C, Houston, D K, Hu, F, Langenberg, C, McKeown, N M, Mozaffarian, D, North, K E, Viikari, J, Zillikens, M C, Djoussé, L, Hofman, A, Kähönen, M, Kabagambe, E K, Loos, R J F, Saylor, G B, Forouhi, N G, Liu, Y, Mukamal, K J, Chen, Y-DI, Tsai, M Y, Uitterlinden, A G, Raitakari, O, van Duijn, C M, Arnett, D K, Borecki, I B, Cupples, L A, Ferrucci, L, Kritchevsky, S B, Lehtimäki, T, Qi, Lu, Rotter, J I, Siscovick, D S, Wareham, N J, Witteman, J C M, Ordovás, J M, Nettleton, J A

“…Objective: Low-density lipoprotein-related receptor protein 1 (LRP1) is a multi-functional endocytic receptor and signaling molecule that is expressed in…”
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The association between LRP-1 variants and chylomicron uptake after a high fat meal by Frazier-Wood, A.C, Kabagambe, E.K, Wojczynski, M.K, Borecki, I.B, Tiwari, H.K, Smith, C.E, Ordovas, J.M, Arnett, D.K

“…Abstract Background and aims In vitro studies suggest that low density lipoprotein receptor-related protein 1 (LRP1) plays a role in the secondary uptake of…”
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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women by Jones, Garan, Trajanoska, Katerina, Santanasto, Adam J., Stringa, Najada, Kuo, Chia-Ling, Atkins, Janice L., Lewis, Joshua R., Duong, ThuyVy, Hong, Shengjun, Biggs, Mary L., Luan, Jian’an, Sarnowski, Chloe, Lunetta, Kathryn L., Tanaka, Toshiko, Wojczynski, Mary K., Cvejkus, Ryan, Nethander, Maria, Ghasemi, Sahar, Yang, Jingyun, Zillikens, M. Carola, Walter, Stefan, Sicinski, Kamil, Kague, Erika, Ackert-Bicknell, Cheryl L., Arking, Dan E., Windham, B. Gwen, Boerwinkle, Eric, Grove, Megan L., Graff, Misa, Spira, Dominik, Demuth, Ilja, van der Velde, Nathalie, de Groot, Lisette C. P. G. M., Psaty, Bruce M., Odden, Michelle C., Fohner, Alison E., Langenberg, Claudia, Wareham, Nicholas J., Bandinelli, Stefania, van Schoor, Natasja M., Huisman, Martijn, Tan, Qihua, Zmuda, Joseph, Mellström, Dan, Karlsson, Magnus, Bennett, David A., Buchman, Aron S., De Jager, Philip L., Uitterlinden, Andre G., Völker, Uwe, Kocher, Thomas, Teumer, Alexander, Rodriguéz-Mañas, Leocadio, García, Francisco J., Carnicero, José A., Herd, Pamela, Bertram, Lars, Ohlsson, Claes, Murabito, Joanne M., Melzer, David, Kuchel, George A., Ferrucci, Luigi, Karasik, David, Rivadeneira, Fernando, Kiel, Douglas P., Pilling, Luke C.

“…Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study…”
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Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation by Longchamps, R. J., Yang, S. Y., Castellani, C. A., Shi, W., Lane, J., Grove, M. L., Bartz, T. M., Sarnowski, C., Liu, C., Burrows, K., Guyatt, A. L., Gaunt, T. R., Kacprowski, T., Yang, J., De Jager, P. L., Yu, L., Bergman, A., Xia, R., Fornage, M., Feitosa, M. F., Wojczynski, M. K., Kraja, A. T., Province, M. A., Amin, N., Rivadeneira, F., Tiemeier, H., Uitterlinden, A. G., Broer, L., Van Meurs, J. B. J., Van Duijn, C. M., Raffield, L. M., Lange, L., Rich, S. S., Lemaitre, R. N., Goodarzi, M. O., Sitlani, C. M., Mak, A. C. Y., Bennett, D. A., Rodriguez, S., Murabito, J. M., Lunetta, K. L., Sotoodehnia, N., Atzmon, G., Ye, K., Barzilai, N., Brody, J. A., Psaty, B. M., Taylor, K. D., Rotter, J. I., Boerwinkle, E., Pankratz, N., Arking, D. E.

“…Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both…”
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The association between LRP1 and chylomicron uptake after the ingestion of a high-fat meal by Frazier-Wood, AC, Kabagambe, EK, Wojczynski, MK, Borecki, IB, Tiwari, HK, Smith, CE, Ordovas, JM, Arnett, DK

“…Doc number: P8…”
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MORBIDITY AND MORTALITY IN CHILDREN AND GRANDCHILDREN OF LONG-LIVED SIBLINGS by Christensen, K, Wojczynski, M K, Pedersen, J K, Larsen, L A, Province, M A

“…, Exceptional longevity and disease-free survival are complex phenomena with a known familial component shown to track to the next generation. We combined…”
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DIGITAL COGNITIVE METRICS OF WRITTEN RESPONSES IN THE LONG LIFE FAMILY STUDY by Sweigart, B, Andersen, S L, Wasserman, B, Cosentino, S, Wojczynski, M K, Au, R, Sebastiani, P, Perls, T T

“…Digital pen data from cognitive test performance can be used to calculate metrics that may reflect aspects of cognition not captured in traditional scores. As…”
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IMPLEMENTATION OF DIGITAL DATA COLLECTION FOR COGNITIVE PERFORMANCE IN THE LONG LIFE FAMILY STUDY by Andersen, S L, Wojczynski, M K, Glynn, N W, Thyagarajan, B, Mengel-From, J, Au, R, Perls, T T, Cosentino, S

“…The Long Life Family Study, a longitudinal study of healthy aging among families with clustering for longevity, is a valuable cohort for identifying early…”
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HERITABILITY AND PREVALENCE OF PERCEIVED PHYSICAL FATIGABILITY IN THE LONG LIFE FAMILY STUDY by LaSorda, K R, Kuipers, A L, Boudreau, R M, Andersen, S L, Cosentino, S, Wojczynski, M K, Christensen, K, Glynn, N W

“…Fatigability is an important early predictor in the disablement pathway, yet little is known about its genetic basis or association with age and sex. We…”
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Sex and race differences in the prevalence of Fatty Liver Disease as measured by CT liver attenuation in European American and African American participants of the NHLBI Family Heart Study by North, K.E., Graff, M, Franceschini, N., Reiner, A.P., Feitosa, M.F., Carr, J.J., Gordon-Larsen, P., Wojczynski, M. K., Borecki, I.B.

“…Liver attenuation (LA) (Hounsfield Units, HU) by computed tomography (CT) is a validated quantitative measure inversely related to liver fat burden. We…”
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Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry by Nettleton, Jennifer A, Follis, Jack L, Ngwa, Julius S, Smith, Caren E, Ahmad, Shafqat, Tanaka, Toshiko, Wojczynski, Mary K, Voortman, Trudy, Lemaitre, Rozenn N, Kristiansson, Kati, Nuotio, Marja-Liisa, Houston, Denise K, Perälä, Mia-Maria, Qi, Qibin, Sonestedt, Emily, Manichaikul, Ani, Kanoni, Stavroula, Ganna, Andrea, Mikkilä, Vera, North, Kari E, Siscovick, David S, Harald, Kennet, Mckeown, Nicola M, Johansson, Ingegerd, Rissanen, Harri, Liu, Yongmei, Lahti, Jari, Hu, Frank B, Bandinelli, Stefania, Rukh, Gull, Rich, Stephen, Booij, Lisanne, Dmitriou, Maria, Ax, Erika, Raitakari, Olli, Mukamal, Kenneth, Männistö, Satu, Hallmans, Göran, Jula, Antti, Ericson, Ulrika, Jacobs, Jr, David R, Van Rooij, Frank J A, Deloukas, Panos, Sjögren, Per, Kähönen, Mika, Djousse, Luc, Perola, Markus, Barroso, Inês, Hofman, Albert, Stirrups, Kathleen, Viikari, Jorma, Uitterlinden, André G, Kalafati, Ioanna P, Franco, Oscar H, Mozaffarian, Dariush, Salomaa, Veikko, Borecki, Ingrid B, Knekt, Paul, Kritchevsky, Stephen B, Eriksson, Johan G, Dedoussis, George V, Qi, Lu, Ferrucci, Luigi, Orho-Melander, Marju, Zillikens, M Carola, Ingelsson, Erik, Lehtimäki, Terho, Renström, Frida, Cupples, L Adrienne, Loos, Ruth J F, Franks, Paul W

“…Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We…”
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Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study by MUALLEM, Hind, NORTH, Kari E, KAKOKI, Masao, WOJCZYNSKI, Mary K, XIA LI, GROVE, Megan, BOERWINKLE, Eric, WILHELMSEN, Kirk C, HEISS, Gerardo, MAEDA, Nobuyo

“…The low-density lipoprotein receptor (LDLR) plays a pivotal role in cholesterol homeostasis. However, the role of genetic variations in the 3'UTR of the LDLR…”
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Irritable Bowel Syndrome: A Co-Twin Control Analysis by WOJCZYNSKI, Mary K, NORTH, Kari E, PEDERSEN, Nancy L, SULLIVAN, Patrick F

“…Among individuals who satisfy diagnostic criteria for both major depressive disorder (MDD) and irritable bowel syndrome (IBS), little is known about the role…”
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