Search Results - "Wojciak, Jonathan M"

A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay by Fleming, Jonathan K., Glass, Thomas R., Lackie, Steve J., Wojciak, Jonathan M.

“…Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive signaling lysophospholipids that activate specific G protein-coupled receptors on…”
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Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains by Wojciak, Jonathan M, Martinez-Yamout, Maria A, Dyson, H Jane, Wright, Peter E

“…CBP/p300 transcriptional coactivators mediate gene expression by integrating cellular signals through interactions with multiple transcription factors. To…”
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Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes by Crack, Peter J, Zhang, Moses, Morganti-Kossmann, Maria Cristina, Morris, Andrew J, Wojciak, Jonathan M, Fleming, Jonathan K, Karve, Ila, Wright, David, Sashindranath, Maithili, Goldshmit, Yona, Conquest, Alison, Daglas, Maria, Johnston, Leigh A, Medcalf, Robert L, Sabbadini, Roger A, Pébay, Alice

“…Lysophosphatidic acid (LPA) is a bioactive phospholipid with a potentially causative role in neurotrauma. Blocking LPA signaling with the LPA-directed…”
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High-affinity pan-specific monoclonal antibodies that target cysteinyl leukotrienes and show efficacy in an acute model of colitis by King, Ashlee N., Fleming, Jonathan K., Knapik, Stephanie S., Visentin, Barbara, Wojciak, Jonathan M., Huxford, Tom

“…Cysteinyl leukotrienes (CysLTs) are a small family of biological signaling lipids produced by active leukocytes that contribute to diverse inflammatory disease…”
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crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen by Wojciak, Jonathan M, Zhu, Norman, Schuerenberg, Karen T, Moreno, Kelli, Shestowsky, William S, Hiraiwa, Masao, Sabbadini, Roger, Huxford, Tom

“…The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, and cancer. LT1009 (also known as…”
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Ion Binding Properties of a Naturally Occurring Metalloantibody by Farokhi, Elinaz, Fleming, Jonathan K, Erasmus, M Frank, Ward, Aaron D, Wu, Yunjin, Gutierrez, Maria G, Wojciak, Jonathan M, Huxford, Tom

“…LT1009 is a humanized version of murine LT1002 IgG1 that employs two bridging Ca ions to bind its antigen, the biologically active lipid…”
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CBP/p300 TAZ1 Domain Forms a Structured Scaffold for Ligand Binding by De Guzman, Roberto N, Wojciak, Jonathan M, Martinez-Yamout, Maria A, Dyson, H. Jane, Wright, Peter E

“…The transcriptional coactivator protein CBP and its paralog p300 each contain two homologous zinc-containing TAZ domains, which constitute the interaction…”
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RNA Binding by the KTS Splice Variants of Wilms’ Tumor Suppressor Protein WT1 by Nishikawa, Tadateru, Wojciak, Jonathan M, Dyson, H. Jane, Wright, Peter E

“…Wilms’ tumor suppressor protein WT1 regulates the expression of multiple genes through binding of the Cys2-His2 zinc finger domain to promoter sites. WT1 has…”
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Matrix-Assisted Laser Desorption Ionization Mapping of Lysophosphatidic Acid Changes after Traumatic Brain Injury and the Relationship to Cellular Pathology by McDonald, Whitney S., Jones, Elizabeth E., Wojciak, Jonathan M., Drake, Richard R., Sabbadini, Roger A., Harris, Neil G.

“…Lysophosphatidic acid (LPA) levels increase in the cerebrospinal fluid and blood within 24 hours after traumatic brain injury (TBI), indicating it may be a…”
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Arm-Site Binding by λ-Integrase: Solution Structure and Functional Characterization of Its Amino-Terminal Domain by Wojciak, Jonathan M., Sarkar, Dibyendu, Landy, Arthur, Clubb, Robert T.

“…The integrase protein (Int) from bacteriophage λ catalyzes the insertion and excision of the viral genome into and out of Escherichia coli. It is a member of…”
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Identification of the λ Integrase Surface That Interacts with Xis Reveals a Residue That Is Also Critical for Int Dimer Formation by Warren, David, Sam, My D., Manley, Kate, Sarkar, Dibyendu, Lee, Sang Yeol, Abbani, Mohamad, Wojciak, Jonathan M., Clubb, Robert T., Landy, Arthur

“…Lambda integrase (Int) is a heterobivalent DNA-binding protein that together with the accessory DNA-bending proteins IHF, Fis, and Xis, forms the higher-order…”
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Biochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal Antibody by Fleming, Jonathan K., Wojciak, Jonathan M., Campbell, Mary-Ann, Huxford, Tom

“…Lysophosphatidic acid (LPA) is a common product of glycerophospholipid metabolism and an important mediator of signal transduction. Aberrantly high LPA…”
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NMR Structure and Functional Studies of the Mu Repressor DNA-Binding Domain by Ilangovan, Udayar, Wojciak, Jonathan M, Connolly, Kevin M, Clubb, Robert T

“…The repressor protein of bacteriophage Mu establishes and maintains lysogeny by shutting down transposition functions needed for phage DNA replication. It…”
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Site-specific DNA binding using a variation of the double stranded RNA binding motif by Clubb, Robert T, Connolly, Kevin M, Wojciak, Jonathan M

“…The integrase family of site-specific recombinases catalyze a diverse array of DNA rearrangements in archaebacteria, eubacteria and yeast. The solution…”
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Regulation of Directionality in Bacteriophage λ Site-specific Recombination: Structure of the Xis Protein by Sam, My D., Papagiannis, Christie V., Connolly, Kevin M., Corselli, Leah, Iwahara, Junji, Lee, James, Phillips, Martin, Wojciak, Jonathan M., Johnson, Reid C., Clubb, Robert T.

“…Upon induction of a bacteriophage λ lysogen, a site-specific recombination reaction excises the phage genome from the chromosome of its bacterial host. A…”
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The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody andits antigen by Wojciak, Jonathan M, Zhu, Norman, Schuerenberg, Karen T, Moreno, Kelli, Shestowsky, William S, Hiraiwa, Masao, Sabbadini, Roger, Huxford, Tom

“…The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, andcancer. LT1009 (also known as…”
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Improved NMR spectra of a protein-DNA complex through rational mutagenesis and the application of a sensitivity optimized isotope-filtered NOESY experiment by Iwahara, J, Wojciak, J M, Clubb, R T

“…The NMR spectra of the complex between the DNA-binding domain of the Dead ringer protein (DRI-DBD, Gly262-Gly398) and its DNA binding site (DRI-DBD:DNA, 26…”
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The Mu repressor-DNA complex contains an immobilized 'wing' within the minor groove by Clubb, Robert T, Wojciak, Jonathan M, Iwahara, Junji

“…We have determined the solution structure of the complex between the 'winged-helix' enhancer binding domain of the Mu repressor protein and its cognate DNA…”
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Finding the function buried in SAND by Clubb, Robert T, Wojciak, Jonathan M

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Major Groove Recognition by Three-stranded β-Sheets: Affinity Determinants and Conserved Structural Features by Connolly, Kevin M., Ilangovan, Udayar, Wojciak, Jonathan M., Iwahara, Mizuho, Clubb, Robert T.

“…We present the results of a rational mutagenesis and binding-affinity study of the three-stranded β-sheet-DNA interface in the complex formed by the…”
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