Search Results - "Wojchowski, D M"

JAK2/Y343/STAT5 signaling axis is required for erythropoietin-mediated protection against ischemic injury in primary renal tubular epithelial cells by Breggia, A C, Wojchowski, D M, Himmelfarb, J

“…Erythropoietin has emerged as a potential therapy for the treatment of ischemic tissue injury. In erythroid cells, the JAK2/Y343/STAT5 signaling axis has been…”
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Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death by PIRCHER, T. J, SHUQING ZHAO, GEIGER, J. N, JONEJA, B, WOJCHOWSKI, D. M

“…The hematopoietic cell S/T kinase Pim-1 was originally discovered as a target of murine leukemia provirus integration, and when expressed at increased levels…”
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Erythropoietin-induced Recruitment of Shc via a Receptor Phosphotyrosine-independent, Jak2-associated Pathway by He, Tong-Chuan, Jiang, Ning, Zhuang, Hongming, Wojchowski, Don M.

“…Based on the recently implicated role of Shc as a signaling effector for type I cytokine receptors, factors which mediate the recruitment and phosphorylation…”
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Proliferative action of erythropoietin is associated with rapid protein tyrosine phosphorylation in responsive B6SUt.EP cells by Quelle, F W, Wojchowski, D M

“…Erythropoietin is a prime regulator of the growth and terminal differentiation of erythroid blood cells. However, little is understood concerning its molecular…”
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Association of the p85 Regulatory Subunit of Phosphatidylinositol 3-Kinase With an Essential Erythropoietin Receptor Subdomain by He, Tong-Chuan, Zhuang, Hongming, Jiang, Ning, Waterfield, Michael D., Wojchowski, Don M.

“…Using an active, HAI epitope-tagged form of the murine erythropoietin (EPO) receptor and via direct coimmunoprecipitation, the p85 regulatory subunit of…”
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Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor by QUELLE, D. E, WOJCHOWSKI, D. M

“…Erythrocyte development in mammals depends in part upon the interaction of the glycopeptide hormone erythropoietin (EPO) with cell surface receptors on…”
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Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization by QUELLE, D. E, QUELLE, F. W, WOJCHOWSKI, D. M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2 by Zhuang, H, Patel, S V, He, T C, Sonsteby, S K, Niu, Z, Wojchowski, D M

“…Receptors for a variety of hematopoietins, interferons alpha/beta and gamma, and growth hormone have recently been shown to mediate rapid, ligand-dependent…”
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A Minimal Cytoplasmic Subdomain of the Erythropoietin Receptor Mediates Erythroid and Megakaryocytic Cell Development by Miller, Chris P., Liu, Zi Y., Noguchi, Constance T., Wojchowski, Don M.

“…Signals provided by the erythropoietin (Epo) receptor are essential for the development of red blood cells, and at least 15 distinct signaling factors are now…”
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pIRES-CD4t, a dicistronic expression vector for MACS- or FACS-based selection of transfected cells by Gaines, P, Wojchowski, D M

“…To facilitate the selection of cell lines expressing transfected genes of interest, a plasmid vector has been constructed that directs the co-expression of…”
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The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells by He, T C, Jiang, N, Zhuang, H, Quelle, D E, Wojchowski, D M

“…The development of erythroid progenitor cells depends upon exposure to the glycoprotein hormone, erythropoietin (EPO). Binding of EPO to its transmembrane…”
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mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development by GEIGER, Justin N, KNUDSEN, Geoffry T, WOJCHOWSKI, Don M, PANEK, Leigh, PANDIT, Ajay K, YODER, Michael D, LORD, Kenneth A, CREASY, Caretha L, BURNS, Brian M, GAINES, Peter, DILLON, Susan B

“…DYRKs are a new subfamily of dual-specificity kinases that was originally discovered on the basis of homology to Yak1, an inhibitor of cell cycle progression…”
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Mechanisms of Stem Cell Factor and Erythropoietin Proliferative Co-signaling in FDC2-ER Cells by Joneja, Bhavana, Chen, Hong-Chi, Seshasayee, Dhaya, Wrentmore, Amy L., Wojchowski, Don M.

“…Studies of hematopoietic progenitor cell development in vivo, ex vivo, and in factor-dependent cell lines have shown that c-kit promotes proliferation through…”
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Signal Transduction in the Erythropoietin Receptor System by Wojchowski, Don M., Gregory, Richard C., Miller, Chris P., Pandit, Ajay K., Pircher, Tony J.

“…Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential for the development of committed erythroid progenitor cells beyond…”
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Erythropoietin rapidly alters phosphorylation of pp43, an erythroid membrane protein by Choi, H.S., Wojchowski, D.M., Sytkowski, A.J.

“…The phosphorylation of a prominent 43-kDa phosphoprotein (pp43) in the membranes of normal murine erythroid cells was reduced markedly by exposure of the…”
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Signal transduction in the erythropoietin receptor system by Wojchowski, D M, He, T C

“…Developing erythroid cells require the glycoprotein hormone, erythropoietin (EPO) as an activator of the rapid proliferation of early proerythroblasts (colony…”
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Receptor-targeted transfection using stable maleimido-transferrin/thio-poly-L-lysine conjugates by Taxman, D J, Lee, E S, Wojchowski, D M

“…Cell surface ligand-receptor systems provide favorable routes for DNA transfection due to target cell specificity, transfer efficiency, and low toxicity. Using…”
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Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells by Quelle, F W, Quelle, D E, Wojchowski, D M

“…Receptors for the hematopoietic growth factors erythropoietin, interleukin 3 (IL-3), and granulocyte-macrophage colony-stimulating factor (GM-CSF) are members…”
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Erythropoietin Receptor and STAT5-Specific Pathways Promote SKT6 Cell Hemoglobinization by Gregory, Richard C., Jiang, Ning, Todokoro, Kazuo, Crouse, Jill, Pacifici, Robert E., Wojchowski, Don M.

“…Erythrocyte production in mammals is known to depend on the exposure of committed progenitor cells to the glycoprotein hormone erythropoietin (Epo). In…”
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DYRK gene structure and erythroid-restricted features of DYRK3 gene expression by Zhang, Diya, Li, Ke, Erickson-Miller, Connie L., Weiss, Mitch, Wojchowski, Don M.

“…DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. Up to seven mammalian DYRK…”
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