Search Results - "Woithe, Katharina"
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brain-specific cytochrome P450 responsible for the majority of deltamethrin resistance in the QTC279 strain of Tribolium castaneum
Published in Proceedings of the National Academy of Sciences - PNAS (11-05-2010)“…Cytochrome P450-mediated detoxification is one of the most important mechanisms involved in insecticide resistance. However, the molecular basis of this…”
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Oxidative Phenol Coupling Reactions Catalyzed by OxyB: A Cytochrome P450 from the Vancomycin Producing Organism. Implications for Vancomycin Biosynthesis
Published in Journal of the American Chemical Society (30-05-2007)“…OxyB is a cytochrome P450 enzyme that catalyzes the first phenol coupling reaction during the biosynthesis of vancomycin-like glycopeptide antibiotics. The…”
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Asymmetric total synthesis of the indole alkaloid cyclopiazonic acid and first structure–activity data
Published in Tetrahedron (29-04-2011)“…The indole alkaloid α-cyclopiazonic acid (CPA) is one of the few known inhibitors of sarco( endo)plasmic reticulum Ca 2+-ATPase (SERCA) besides the terpenoids…”
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Intermolecular Radical Addition and Addition/Cyclization Reactions of Alkoxyamines onto Nonactivated Alkenes
Published in Organic letters (07-08-2003)“…Alkoxyamines A, which are readily prepared from commercially available starting materials, undergo efficient thermal radical carboaminoxylations onto various…”
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An Oxidative Phenol Coupling Reaction Catalyzed by OxyB, a Cytochrome P450 from the Vancomycin-Producing Microorganism
Published in Angewandte Chemie International Edition (10-12-2004)“…During the biosynthesis of glycopeptide antibiotics of the vancomycin family, several oxidative phenol coupling reactions take place. An oxygenase (OxyB) from…”
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Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis
Published in Organic & biomolecular chemistry (21-08-2008)“…OxyB is a cytochrome P450 enzyme that catalyzes the first oxidative phenol coupling reaction during vancomycin biosynthesis. The preferred substrate is a…”
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New insights into the first oxidative phenol coupling reaction during vancomycin biosynthesis
Published in Bioorganic & medicinal chemistry (15-05-2008)“…Label from 18O 2 is not incorporated into the monocyclic product shown during catalysis by OxyB. Also, a model hexapeptide containing ( R)-Tyr6, instead of (…”
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An Oxidative Phenol Coupling Reaction Catalyzed by OxyB, a Cytochrome P450 from the Vancomycin-Producing Microorganism
Published in Angewandte Chemie (10-12-2004)“…Teil der Biosynthese von Glycopeptidantibiotika der Vancomycin‐Familie sind mehrere oxidative Phenolkupplungsreaktionen. Eine Oxygenase (OxyB) des…”
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Chapter 19. In vitro studies of phenol coupling enzymes involved in vancomycin biosynthesis
Published in Methods in enzymology (2009)“…Oxidative phenol cross-linking reactions play a key role in the biosynthesis of glycopeptide antibiotics such as vancomycin. The vancomycin aglycone contains…”
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