Search Results - "Woillard, Jean‐Baptiste"

Tacrolimus Exposure Prediction Using Machine Learning by Woillard, Jean‐Baptiste, Labriffe, Marc, Debord, Jean, Marquet, Pierre

“…The aim of this work is to estimate the area‐under the blood concentration curve of tacrolimus (TAC) following b.i.d. or q.d. dosing in organ transplant…”
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Nonparametric Methods in Population Pharmacokinetics by Goutelle, Sylvain, Woillard, Jean‐Baptiste, Neely, Michael, Yamada, Walter, Bourguignon, Laurent

“…Population pharmacokinetic (PK) modeling is a widely used approach to analyze PK data obtained from groups of individuals, in both industry and academic…”
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Mycophenolic Acid Exposure Prediction Using Machine Learning by Woillard, Jean‐Baptiste, Labriffe, Marc, Debord, Jean, Marquet, Pierre

“…Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well‐established and machine learning (ML) approaches could help…”
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Pharmacokinetics, Pharmacodynamics, and Therapeutic Drug Monitoring of Valganciclovir and Ganciclovir in Transplantation by Franck, Bénédicte, Autmizguine, Julie, Marquet, Pierre, Ovetchkine, Philippe, Woillard, Jean‐Baptiste

“…Ganciclovir and valganciclovir are first choice drugs for the prevention and treatment of cytomegalovirus infection and disease in solid organ and stem cell…”
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Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts’ Discussion on Use, Strengths, and Limitations by Goutelle, Sylvain, Woillard, Jean‐Baptiste, Buclin, Thierry, Bourguignon, Laurent, Yamada, Walter, Csajka, Chantal, Neely, Michael, Guidi, Monia

“…Population pharmacokinetics consists of analyzing pharmacokinetic (PK) data collected in groups of individuals. Population PK is widely used to guide drug…”
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Machine learning‐supported interpretation of kidney graft elementary lesions in combination with clinical data by Labriffe, Marc, Woillard, Jean‐Baptiste, Gwinner, Wilfried, Braesen, Jan‐Hinrich, Anglicheau, Dany, Rabant, Marion, Koshy, Priyanka, Naesens, Maarten, Marquet, Pierre

“…Interpretation of kidney graft biopsies using the Banff classification is still heterogeneous. In this study, extreme gradient boosting classifiers learned…”
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Tacrolimus population pharmacokinetics in adult heart transplant patients by Paschier, Adrien, Destere, Alexandre, Monchaud, Caroline, Labriffe, Marc, Marquet, Pierre, Woillard, Jean‐Baptiste

“…Introduction Tacrolimus is an immunosuppressant largely used in heart transplantation. However, the calculation of its exposure based on the area under the…”
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Machine learning algorithms to estimate everolimus exposure trained on simulated and patient pharmacokinetic profiles by Labriffe, Marc, Woillard, Jean‐Baptiste, Debord, Jean, Marquet, Pierre

“…Everolimus is an immunosuppressant with a small therapeutic index and large between‐patient variability. The area under the concentration versus time curve…”
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A donor and recipient candidate gene association study of allograft loss in renal transplant recipients receiving a tacrolimus‐based regimen by Woillard, Jean‐Baptiste, Gatault, Philippe, Picard, Nicolas, Arnion, Hélène, Anglicheau, Dany, Marquet, Pierre

“…This work investigated, in two large cohorts of French renal transplants treated with tacrolimus, the influence of donor and recipient ABCB1, CYP3A4, and…”
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Diagnostic, prognostic and clinical value of left ventricular radial strain to identify paradoxical septal motion in ventilated patients with the acute respiratory distress syndrome: an observational prospective multicenter study by Evrard, Bruno, Woillard, Jean-Baptiste, Legras, Annick, Bouaoud, Misylias, Gourraud, Maeva, Humeau, Antoine, Goudelin, Marine, Vignon, Philippe

“…Background Acute cor pulmonale (ACP) is prognostic in patients with acute respiratory distress syndrome (ARDS). Identification of paradoxical septal motion…”
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Population Pharmacokinetics and Bayesian Estimators for Refined Dose Adjustment of a New Tacrolimus Formulation in Kidney and Liver Transplant Patients by Woillard, Jean-Baptiste, Debord, Jean, Monchaud, Caroline, Saint-Marcoux, Franck, Marquet, Pierre

“…Background and Objectives A new once-daily formulation of tacrolimus (Envarsus ® ) has recently been developed, with alleged different pharmacokinetics from…”
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Therapeutic Drug Monitoring of Everolimus in Oncology: Evidences and Perspectives by Falkowski, Sabrina, Woillard, Jean-Baptiste

“…Everolimus is a mammalian target of rapamycin (m-TOR) inhibitor that has been approved for the treatment of hormone receptor-positive advanced breast cancer,…”
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Population pharmacokinetic model and Bayesian estimator for 2 tacrolimus formulations in adult liver transplant patients by Riff, Camille, Debord, Jean, Monchaud, Caroline, Marquet, Pierre, Woillard, Jean‐Baptiste

“…Aims Tacrolimus is a narrow therapeutic range drug that requires fine dose adjustment, for which pharmacokinetic (PK) models have been amply proposed in renal,…”
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Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology by Bergan, Stein, Brunet, Mercè, Hesselink, Dennis A., Johnson-Davis, Kamisha L., Kunicki, Paweł K., Lemaitre, Florian, Marquet, Pierre, Molinaro, Mariadelfina, Noceti, Ofelia, Pattanaik, Smita, Pawinski, Tomasz, Seger, Christoph, Shipkova, Maria, Swen, Jesse J., van Gelder, Teun, Venkataramanan, Raman, Wieland, Eberhard, Woillard, Jean-Baptiste, Zwart, Tom C., Barten, Markus J., Budde, Klemens, Dieterlen, Maja-Theresa, Elens, Laure, Haufroid, Vincent, Masuda, Satohiro, Millan, Olga, Mizuno, Tomoyuki, Moes, Dirk J. A. R., Oellerich, Michael, Picard, Nicolas, Salzmann, Linda, Tönshoff, Burkhard, van Schaik, Ron H. N., Vethe, Nils Tore, Vinks, Alexander A., Wallemacq, Pierre, Åsberg, Anders, Langman, Loralie J.

“…When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the…”
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Why dose adjust systemic exposure when looking for associations with adverse events in tacrolimus‐treated transplant recipients? by Robertsen, Ida, Woillard, Jean‐Baptiste, Åsberg, Anders

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Population pharmacokinetics and Bayesian estimators for intravenous mycophenolate mofetil in haematopoietic stem cell transplant patients by Labriffe, Marc, Vaidie, Julien, Monchaud, Caroline, Debord, Jean, Turlure, Pascal, Girault, Stephane, Marquet, Pierre, Woillard, Jean‐Baptiste

“…Aims Intravenous mycophenolate mofetil (IV MMF), a prodrug of mycophenolic acid (MPA), is used during nonmyeloablative and reduced‐intensity conditioning…”
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Pharmacokinetic models to assist the prescriber in choosing the best tacrolimus dose by Woillard, Jean-Baptiste, Saint-Marcoux, Franck, Debord, Jean, Åsberg, Anders

“…[Display omitted] Due to a high inter-individual variability in its pharmacokinetics, tacrolimus dose individualization is mandatory. Even though the expert…”
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Endogenous Metabolites‐Mediated Communication Between OAT1/OAT3 and OATP1B1 May Explain the Association Between SLCO1B1 SNPs and Methotrexate Toxicity by Martinez, David, Muhrez, Kienana, Woillard, Jean‐Baptiste, Berthelot, Aline, Gyan, Emmanuel, Choquet, Sylvain, Andrès, Christian R., Marquet, Pierre, Barin‐Le Guellec, Chantal

“…Although OATP1B1 is not expressed in the kidney, polymorphisms in SLCO1B1 have been associated with methotrexate clearance or toxicity. This unexpected…”
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Population pharmacokinetics and Bayesian estimation of mycophenolate mofetil in patients with autoimmune hepatitis by Nanga, Tom M., Woillard, Jean‐Baptiste, Rousseau, Annick, Marquet, Pierre, Prémaud, Aurélie

“…Aims Mycophenolate mofetil (MMF) is the most widely used second‐line agent in autoimmune hepatitis (AIH). Individual dose adjustment of MMF may avoid adverse…”
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Towards therapeutic drug monitoring of mycophenolic acid in mucous membrane pemphigoid: A retrospective single‐centre study by Woillard, Jean‐Baptiste, Assikar, Safae, Monchaud, Caroline, Couraud, Amélie, Marquet, Pierre, Bédane, Christophe

“…Background Mycophenolate mofetil (MMF) is theoretically a treatment of choice for mucous membrane pemphigoid (MMP), due to its good long‐term tolerance and…”
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