Search Results - "Wohlbold, Teddy"

In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen by Wohlbold, Teddy John, Krammer, Florian

“…Despite the availability of vaccine prophylaxis and antiviral therapeutics, the influenza virus continues to have a significant, annual impact on the morbidity…”
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Broadly protective human antibodies that target the active site of influenza virus neuraminidase by Stadlbauer, Daniel, Zhu, Xueyong, McMahon, Meagan, Turner, Jackson S, Wohlbold, Teddy J, Schmitz, Aaron J, Strohmeier, Shirin, Yu, Wenli, Nachbagauer, Raffael, Mudd, Philip A, Wilson, Ian A, Ellebedy, Ali H, Krammer, Florian

“…Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are…”
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An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations by Rajendran, Madhusudan, Sun, Weina, Comella, Phillip, Nachbagauer, Raffael, Wohlbold, Teddy John, Amanat, Fatima, Kirkpatrick, Ericka, Palese, Peter, Krammer, Florian

“…The standard method to quantify the hemagglutinin content of influenza virus vaccines is the single radial immunodiffusion assay. This assay primarily relies…”
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Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus by Klausberger, Miriam, Tscheliessnig, Rupert, Neff, Silke, Nachbagauer, Raffael, Wohlbold, Teddy John, Wilde, Monika, Palmberger, Dieter, Krammer, Florian, Jungbauer, Alois, Grabherr, Reingard

“…Significant genetic variability in the head region of the influenza A hemagglutinin, the main target of current vaccines, makes it challenging to develop a…”
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Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans by Nachbagauer, Raffael, Wohlbold, Teddy John, Hirsh, Ariana, Hai, Rong, Sjursen, Haakon, Palese, Peter, Cox, Rebecca J, Krammer, Florian

“…Influenza virus infections are a major public health concern and cause significant morbidity and mortality worldwide. Current vaccines are effective but strain…”
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Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine by Matsuda, Kenta, Huang, Jinghe, Zhou, Tongqing, Sheng, Zizhang, Kang, Byong H, Ishida, Elise, Griesman, Trevor, Stuccio, Sarah, Bolkhovitinov, Lyuba, Wohlbold, Teddy J, Chromikova, Veronika, Cagigi, Alberto, Leung, Kwanyee, Andrews, Sarah, Cheung, Crystal S F, Pullano, Alyssa A, Plyler, Jason, Soto, Cinque, Zhang, Baoshan, Yang, Yongping, Joyce, M Gordon, Tsybovsky, Yaroslav, Wheatley, Adam, Narpala, Sandeep R, Guo, Yicheng, Darko, Sam, Bailer, Robert T, Poole, April, Liang, C Jason, Smith, Jon, Alexander, Jeff, Gurwith, Marc, Migueles, Stephen A, Koup, Richard A, Golding, Hana, Khurana, Surender, McDermott, Adrian B, Shapiro, Lawrence, Krammer, Florian, Kwong, Peter D, Connors, Mark

“…Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and…”
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Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus by Ramos, Irene, Mansour, Mena, Wohlbold, Teddy J, Ermler, Megan E, Hirsh, Ariana, Runstadler, Jonathan A, Fernandez-Sesma, Ana, Krammer, Florian

“…Three cases of influenza A(H10N8) virus infection in humans have been reported; 2 of these infected persons died. Characterization of the receptor binding…”
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Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice by Wohlbold, Teddy John, Chromikova, Veronika, Tan, Gene S, Meade, Philip, Amanat, Fatima, Comella, Phillip, Hirsh, Ariana, Krammer, Florian

“…Between November 2013 and February 2014, China reported three human cases of H10N8 influenza virus infection in the Jiangxi province, two of which were fatal…”
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Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice by Wohlbold, Teddy John, Nachbagauer, Raffael, Xu, Haoming, Tan, Gene S, Hirsh, Ariana, Brokstad, Karl A, Cox, Rebecca J, Palese, Peter, Krammer, Florian

“…In an attempt to assess the cross-protective potential of the influenza virus neuraminidase (NA) as a vaccine antigen, different subtypes of recombinant NA…”
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Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes by Wohlbold, Teddy John, Podolsky, Kira A., Chromikova, Veronika, Kirkpatrick, Ericka, Falconieri, Veronica, Meade, Philip, Amanat, Fatima, Tan, Jessica, tenOever, Benjamin R., Tan, Gene S., Subramaniam, Sriram, Palese, Peter, Krammer, Florian

“…A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two…”
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Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate by Tran, Erin E H, Podolsky, Kira A, Bartesaghi, Alberto, Kuybeda, Oleg, Grandinetti, Giovanna, Wohlbold, Teddy John, Tan, Gene S, Nachbagauer, Raffael, Palese, Peter, Krammer, Florian, Subramaniam, Sriram

“…Influenza viruses expressing chimeric hemagglutinins (HAs) are important tools in the quest for a universal vaccine. Using cryo-electron tomography, we have…”
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Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice by Asthagiri Arunkumar, Guha, Ioannou, Andriani, Wohlbold, Teddy John, Meade, Philip, Aslam, Sadaf, Amanat, Fatima, Ayllon, Juan, García-Sastre, Adolfo, Krammer, Florian

“…Protection from influenza virus infection is canonically associated with antibodies that neutralize the virus by blocking the interaction between the viral…”
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Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies by Chen, Yao-Qing, Wohlbold, Teddy John, Zheng, Nai-Ying, Huang, Min, Huang, Yunping, Neu, Karlynn E., Lee, Jiwon, Wan, Hongquan, Rojas, Karla Thatcher, Kirkpatrick, Ericka, Henry, Carole, Palm, Anna-Karin E., Stamper, Christopher T., Lan, Linda Yu-Ling, Topham, David J., Treanor, John, Wrammert, Jens, Ahmed, Rafi, Eichelberger, Maryna C., Georgiou, George, Krammer, Florian, Wilson, Patrick C.

“…Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we…”
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Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses by Wohlbold, Teddy John, Nachbagauer, Raffael, Margine, Irina, Tan, Gene S, Hirsh, Ariana, Krammer, Florian

“…Abstract Current influenza virus vaccines provide solid protection from infection with viruses that are well matched with the vaccine strains. However, they do…”
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An H10N8 influenza virus vaccine strain and mouse challenge model based on the human isolate A/Jiangxi-Donghu/346/13 by Wohlbold, Teddy John, Hirsh, Ariana, Krammer, Florian

“…Abstract Three human cases of H10N8 viruses were reported in China in late 2013 and early 2014, two of which were fatal. This was the first time the H10N8…”
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Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial by Bernstein, David I, Guptill, Jeffrey, Naficy, Abdollah, Nachbagauer, Raffael, Berlanda-Scorza, Francesco, Feser, Jodi, Wilson, Patrick C, Solórzano, Alicia, Van der Wielen, Marie, Walter, Emmanuel B, Albrecht, Randy A, Buschle, Kristen N, Chen, Yao-qing, Claeys, Carine, Dickey, Michelle, Dugan, Haley L, Ermler, Megan E, Freeman, Debra, Gao, Min, Gast, Christopher, Guthmiller, Jenna J, Hai, Rong, Henry, Carole, Lan, Linda Yu-Ling, McNeal, Monica, Palm, Anna-Karin E, Shaw, Dustin G, Stamper, Christopher T, Sun, Weina, Sutton, Victoria, Tepora, Micah E, Wahid, Rahnuma, Wenzel, Heather, Wohlbold, Teddy John, Innis, Bruce L, García-Sastre, Adolfo, Palese, Peter, Krammer, Florian

“…Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the…”
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SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19 by Rybkina, Ksenia, Bell, Joseph N, Bradley, Marissa C, Wohlbold, Teddy, Scafuro, Marika, Meng, Wenzhao, Korenberg, Rebecca C, Davis-Porada, Julia, Anderson, Brett R, Weller, Rachel J, Milner, Joshua D, Moscona, Anne, Porotto, Matteo, Luning Prak, Eline T, Pethe, Kalpana, Connors, Thomas J, Farber, Donna L

“…SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare cases severe disease can develop, including a multisystem…”
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Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model by Duehr, James, Wohlbold, Teddy John, Oestereich, Lisa, Chromikova, Veronika, Amanat, Fatima, Rajendran, Madhusudan, Gomez-Medina, Sergio, Mena, Ignacio, tenOever, Benjamin R, García-Sastre, Adolfo, Basler, Christopher F, Munoz-Fontela, Cesar, Krammer, Florian

“…Out of an estimated 31,100 cases since their discovery in 1976, ebolaviruses have caused approximately 13,000 deaths. The vast majority (∼11,000) of these…”
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A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies by Nachbagauer, Raffael, Liu, Wen-Chun, Choi, Angela, Wohlbold, Teddy John, Atlas, Talia, Rajendran, Madhusudan, Solórzano, Alicia, Berlanda-Scorza, Francesco, García-Sastre, Adolfo, Palese, Peter, Albrecht, Randy A., Krammer, Florian

“…Influenza viruses evade human adaptive immune responses due to continuing antigenic changes. This makes it necessary to re-formulate and re-administer current…”
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Cryo-EM Tomographic Analysis of a Universal Influenza Virus Vaccine Candidate by Tran, Erin, Podolsky, Kira, Bartesaghi, Alberto, Kuybeda, Oleg, Grandinetti, Giovanna, John Wohlbold, Teddy, Tan, Gene, Nachbagauer, Raffael, Palese, Peter, Krammer, Florian, Subramaniam, Sriram

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