Search Results - "Wogensen, L"

Erythropoietin administration is associated with short-term improvement in glomerular filtration rate after ischemia-reperfusion injury by SØLLING, C., CHRISTENSEN, A. T., KRAG, S., FRØKIÆR, J., WOGENSEN, L., KROG, J., TØNNESEN, E. K.

“…Background: Erythropoietin (EPO) is a cytokine with organ‐protective properties. We hypothesized that EPO could attenuate acute renal dysfunction and…”
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Erythropoietin does not attenuate renal dysfunction or inflammation in a porcine model of endotoxemia by SØLLING, C., CHRISTENSEN, A. T., NYGAARD, U., KRAG, S., FRØKIÆR, J., WOGENSEN, L., KROG, J., TØNNESEN, E. K.

“…Background: Erythropoietin (EPO) is a multifunctional cytokine with anti‐apoptotic, anti‐inflammatory, and organ protective effects. EPO protects against…”
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Does brain death induce a pro-inflammatory response at the organ level in a porcine model? by BARKLIN, A., LARSSON, A., VESTERGAARD, C., KOEFOED-NIELSEN, J., BACH, A., NYBOE, R., WOGENSEN, L., TØNNESEN, E.

“…Background: Organs from brain‐dead donors have a poorer prognosis after transplantation than organs from living donors. A possible explanation for this is that…”
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Insulin alters cytokine content in two pivotal organs after brain death: a porcine model by BARKLIN, A., LARSSON, A., VESTERGAARD, C., KJAERGAARD, A., WOGENSEN, L., SCHMITZ, O., TØNNESEN, E.

“…Background: To optimize the quantity and quality of organs available for transplantation, it is crucial to gain further insight into the treatment of brain…”
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Renal cytokine profile in an endotoxemic porcine model by GRANFELDT, A., EBDRUP, L., TØNNESEN, E., WOGENSEN, L.

“…Introduction: In animals exposed to acute endotoxemia with lipopolysaccharide (LPS), high levels of cytokines are found in the kidney. The objective of this…”
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Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice by WOGENSEN, L, MYUNG-SHIK LEE, SARVETNICK, N

“…The T helper type 2 (Th2) cell product interleukin 10 (IL-10) inhibits the proliferation and function of Th1 lymphocytes and macrophages (M phi). The nonobese…”
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Real-time PCR: housekeeping genes in the INS-1E beta-cell line by Smidt, K, Wogensen, L, Brock, B, Schmitz, O, Rungby, J

“…Investigation of gene expression is a developing area with several methods available. One method is quantitative PCR. A major pitfall in quantitative PCR is…”
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The use of transgenic animals in the study of diabetic kidney disease by Wogensen, L, Krag, S, Chai, Q, Ledet, T

“…Diabetic nephropathy is one of the most common diseases leading to fibrosis and end-stage renal disease (ESRD) world wide. Under normal conditions, a delicate…”
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Myasthenia gravis-like syndrome induced by expression of interferon gamma in the neuromuscular junction by Gu, D, Wogensen, L, Calcutt, N A, Xia, C, Zhu, S, Merlie, J P, Fox, H S, Lindstrom, J, Powell, H C, Sarvetnick, N

“…Abnormal humoral responses toward motor end plate constituents in muscle induce myasthenia gravis (MG). To study the etiology of this disease, and whether it…”
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Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury by Mandrup-Poulsen, Thomas, Wogensen, Lise D, Jensen, Michael, Svensson, Preben, Nilsson, Povl, Emdal, Thorkil, Molvig, Jens, Dinarello, Charles A, Nerup, Jorn

“…OBJECTIVETo investigate the balance between circulating concentrations of interleukin (IL)-1 and its natural inhibitor interleukin-1 receptor antagonist…”
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Mechanisms of pancreatic beta-cell destruction in type I diabetes by Nerup, J, Mandrup-Poulsen, T, Mølvig, J, Helqvist, S, Wogensen, L, Egeberg, J

“…The pathogenetic mechanisms leading to beta-cell destruction and insulin-dependent diabetes mellitus (IDDM) are major histocompatibility complex (MHC)…”
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Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals by Mølvig, J, Pociot, F, Worsaae, H, Wogensen, L D, Baek, L, Christensen, P, Mandrup-Poulsen, T, Andersen, K, Madsen, P, Dyerberg, J

“…The effects of dietary supplementation with omega-3-polyunsaturated fatty acids (omega-3-PUFA) on the proliferative response of PBMC and on the secretion of…”
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A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin-dependent diabetes mellitus by Pociot, F, Mølvig, J, Wogensen, L, Worsaae, H, Dalbøge, H, Baek, L, Nerup, J

“…HLA-class III region genes may be associated with susceptibility to insulin-dependent diabetes mellitus (IDDM). In this study an NcoI polymorphism of the…”
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Pancreatic beta-cell function and interleukin-1 beta in plasma during the acute phase response in patients with major burn injuries by Wogensen, L, Jensen, M, Svensson, P, Worsaae, H, Welinder, B, Nerup, J

“…Animal experiments demonstrate that interleukin-1 beta (IL-1 beta) is beta-cell cytotoxic in vitro and inhibits insulin secretion in vivo. However, it is…”
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Under control of the Ren-1c promoter, locally produced transforming growth factor-beta1 induces accumulation of glomerular extracellular matrix in transgenic mice by Wogensen, L, Nielsen, C B, Hjorth, P, Rasmussen, L M, Nielsen, A H, Gross, K, Sarvetnick, N, Ledet, T

“…Under control of the Ren-1c promoter, locally produced transforming growth factor-beta1 induces accumulation of glomerular extracellular matrix in transgenic…”
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Repetitive in vivo treatment with human recombinant interleukin-1β modifies Beta-cell function in normal rats by WOGENSEN, L. D, REIMERS, J, NERUP, J, KOLB-BACHOFEN, V, KRÖNCKE, K.-D, ALMDAL, T, MANDRUP-POULSEN, T

“…It is unknown whether interleukin-1 exerts a bimodal effect on Beta-cell function in vivo, and whether interleukin-1 has a diabetogenic action in normal…”
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The pharmacokinetics, distribution and degradation of human recombinant interleukin 1 beta in normal rats by Reimers, J, Wogensen, L D, Welinder, B, Hejnaes, K R, Poulsen, S S, Nilsson, P, Nerup, J

“…Based upon in vivo rat experiments it was recently suggested that interleukin 1 in the circulation may be implicated in the initial events of beta-cell…”
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Monocyte function in IDDM patients and healthy individuals by Mølvig, J, Pociot, F, Baek, L, Worsaae, H, Dall Wogensen, L, Christensen, P, Staub-Nielsen, L, Mandrup-Poulsen, T, Manogue, K, Nerup, J

“…Interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF-alpha) may be pathogenetically important in insulin-dependent diabetes mellitus (IDDM),…”
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Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas by Wogensen, L D, Kolb-Bachofen, V, Christensen, P, Dinarello, C A, Mandrup-Poulsen, T, Martin, S, Nerup, J

“…We recently reported a potentiating effect of recombinant human interleukin-1 beta on glucose-stimulated insulin release from the isolated perfused pancreas…”
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Plasminogen activator inhibitor-1 gene deficiency attenuates TGF- beta 1-induced kidney disease by Krag, Soeren, Danielsen, Carl Christian, Carmeliet, Peter, Nyengaard, Jens, Wogensen, Lise

“…Background. Transforming growth factor- beta 1 (TGF- beta 1) stimulates the deposition of extracellular matrix (ECM), which is a hallmark in end-stage renal…”
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