Search Results - "Woerner, Stefan M."

Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors by Woerner, Stefan M., Tosti, Elena, Yuan, Yan P., Kloor, Matthias, Bork, Peer, Edelmann, Winfried, Gebert, Johannes

“…Different DNA mismatch repair (MMR)‐deficient mouse strains have been developed as models for the inherited cancer predisposing Lynch syndrome. It is…”
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(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A by Michalak, Malwina, Katzenmaier, Eva-Maria, Roeckel, Nina, Woerner, Stefan M, Fuchs, Vera, Warnken, Uwe, Yuan, Yan P, Bork, Peer, Neu-Yilik, Gabriele, Kulozik, Andreas, von Knebel Doeberitz, Magnus, Kloor, Matthias, Kopitz, Jürgen, Gebert, Johannes

“…DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate numerous frameshift mutations at repetitive sequences recognized as microsatellite…”
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Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers by KLOOR, Matthias, BECKER, Christina, BENNER, Axel, WOERNER, Stefan M, GEBERT, Johannes, FERRONE, Soldano, VON KNEBEL DOEBERITZ, Magnus

“…In colorectal cancer, the immune response is particularly pronounced against tumors displaying the high microsatellite instability (MSI-H) phenotype. MSI-H…”
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T25 repeat in the 3' untranslated region of the CASP2 gene : A sensitive and specific marker for microsatellite instability in colorectal cancer by FINDEISEN, Peter, KLOOR, Matthias, WAGNER, Rudolf, GEBERT, Johannes, VON KNEBEL DOEBERITZ, Magnus, MERX, Sabine, SUTTER, Christian, WOERNER, Stefan M, DOSTMANN, Nicole, BENNER, Axel, DONDOG, Bolormaa, PAWLITA, Michael, DIPPOLD, Wolfgang

“…DNA mismatch repair deficiency is observed in about 10% to 15% of all colorectal carcinomas and in up to 90% of hereditary nonpolyposis colorectal cancer…”
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Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes by WOERNER, Stefan M, BENNER, Axel, SUTTER, Christian, SCHILLER, Marian, YUAN, Yan P, KELLER, Gisela, BORK, Peer, VON KNEBEL DOEBERITZ, Magnus, GEBERT, Johannes F

“…DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other…”
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Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors by ALAZZOUZI, Hafid, DAVALOS, Veronica, IMAI, Kohzoh, YAMAMOTO, Hiroyuki, MARIADASON, John M, GEBERT, Johannes F, AALTONEN, Lauri A, SCHWARTZ, Simo JR, ARANGO, Diego, KOKKO, Antti, DOMINGO, Enric, WOERNER, Stefan M, WILSON, Andrew J, KONRAD, Lars, LAIHO, Päivi, ESPIN, Eloi, ARMENGOL, Manel

“…The receptor tyrosine kinase EPHB2 has recently been shown to be a direct transcriptional target of TCF/beta-catenin. Premalignant lesions of the colon express…”
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Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability by Korff, Sebastian, Woerner, Stefan M, Yuan, Yan P, Bork, Peer, von Knebel Doeberitz, Magnus, Gebert, Johannes

“…Protein tyrosine phosphatases (PTPs) like their antagonizing protein tyrosine kinases are key regulators of signal transduction thereby assuring normal control…”
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Microsatellite instability in the development of DNA mismatch repair deficient tumors by Woerner, Stefan M, Kloor, Matthias, von Knebel Doeberitz, Magnus, Gebert, Johannes F

“…Microsatellites are highly abundant short repetitive sequences found in the genomes across different species. They have gained increasing interest in recent…”
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SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology by Woerner, Stefan M, Yuan, Yan P, Benner, Axel, Korff, Sebastian, von Knebel Doeberitz, Magnus, Bork, Peer

“…About 15% of human colorectal cancers and, at varying degrees, other tumor entities as well as nearly all tumors related to Lynch syndrome are hallmarked by…”
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Patients' safety: is there a systemic release of gentamicin by gentamicin-coated tibia nails in clinical use? by Moghaddam, Arash, Graeser, Viola, Westhauser, Fabian, Dapunt, Ulrike, Kamradt, Till, Woerner, Stefan M, Schmidmaier, Gerhard

“…Osteitis is one of the most serious complications in orthopedic surgery. Expert Tibia Nail (ETN) PROtect™ coated with a biodegradable layer of gentamicin-laden…”
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The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers by Woerner, Stefan M., Kloor, Matthias, Schwitalle, Yvette, Youmans, Hanni, Doeberitz, Magnus von Knebel, Gebert, Johannes, Dihlmann, Susanne

“…Mismatch repair (MMR) deficiency is a major mechanism of colorectal tumorigenesis that is observed in 10–15% of sporadic colorectal cancers and those…”
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Brush border myosin Ia inactivation in gastric but not endometrial tumors by Mazzolini, Rocco, Rodrigues, Paulo, Bazzocco, Sarah, Dopeso, Higinio, Ferreira, Ana M., Mateo‐Lozano, Silvia, Andretta, Elena, Woerner, Stefan M., Alazzouzi, Hafid, Landolfi, Stefania, Hernandez‐Losa, Javier, Macaya, Irati, Suzuki, Hiromu, Ramón y Cajal, Santiago, Mooseker, Mark S., Mariadason, John M., Gebert, Johannes, Hofstra, Robert M.W., Reventós, Jaume, Yamamoto, Hiroyuki, Schwartz, Simo, Arango, Diego

“…Brush border Myosin Ia (MYO1A) has been shown to be frequently mutated in colorectal tumors with microsatellite instability (MSI) and to have tumor suppressor…”
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Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes by KLAES, R, WOERNER, S. M, RIDDER, R, WENTZENSEN, N, DUERST, M, SCHNEIDER, A, LOTZ, B, MELSHEIMER, P, VON KNEBEL DOEBERITZ, M

“…Cervical cancer emerges from cervical intraepithelial neoplasia (CIN) induced by high-risk HPV (HR-HPV) infections. However, the vast majority of CIN lesions…”
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High Frequency of LMAN1 Abnormalities in Colorectal Tumors with Microsatellite Instability by ROECKEL, Nina, WOERNER, Stefan M, KLOOR, Matthias, YUAN, Yan-Ping, PATSOS, Georgios, GROMES, Roland, KOPITZ, Juergen, GEBERT, Johannes

“…Glycosyl epitopes have been identified as tumor-specific markers in colorectal tumors and various lines of evidence indicate the significance of altered…”
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Microsatellite instability of selective target genes in HNPCC-associated colon adenomas by WOERNER, Stefan M, KLOOR, Matthias, PAGENSTECHER, Constanze, SCHACKERT, Hans K, MÖSLEIN, Gabriela, VOGELSANG, Holger, VON KNEBEL DOEBERITZ, Magnus, GEBERT, Johannes F, MUELLER, Annegret, RUESCHOFF, Josef, FRIEDRICHS, Nicolaus, BUETTNER, Reinhard, BUZELLO, Moriz, KIENLE, Peter, KNAEBEL, Hanns-Peter, KUNSTMANN, Erdmute

“…Microsatellite instability (MSI) occurs in most hereditary nonpolyposis colorectal cancers (HNPCC) and less frequently in sporadic tumors as the result of DNA…”
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Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair‐deficient cancer cells by Woerner, Stefan M., Gebert, Johannes, Yuan, Yan P., Sutter, Christian, Ridder, Ruediger, Bork, Peer, von Knebel Doeberitz, Magnus

“…Microsatellite instability (MSI) caused by deficient DNA mismatch‐repair functions is a hallmark of cancers associated with the hereditary nonpolyposis…”
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Sensitive detection of rare cancer cells in sputum and peripheral blood samples of patients with lung cancer by preproGRP‐specific RT‐PCR by Lacroix, Jeannine, Becker, Heinrich D., Woerner, Stefan M., Rittgen, Werner, Drings, Peter, von Knebel Doeberitz, Magnus

“…RT‐PCR‐based amplification of transcripts expressed in cancer but not in normal non‐neoplastic cells is increasingly used for the sensitive detection of rare…”
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T sub(25) Repeat in the 3' Untranslated Region of the CASP2 Gene: A Sensitive and Specific Marker for Microsatellite Instability in Colorectal Cancer by Findeisen, Peter, Kloor, Matthias, Merx, Sabine, Sutter, Christian, Woerner, Stefan M, Dostmann, Nicole, Benner, Axel, Dondog, Bolormaa, Pawlita, Michael, Dippold, Wolfgang, Wagner, Rudolf, Gebert, Johannes, von Knebel Doeberitz, Magnus

“…DNA mismatch repair deficiency is observed in about 10% to 15% of all colorectal carcinomas and in up to 90% of hereditary nonpolyposis colorectal cancer…”
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Expression of CD44 splice variants in normal respiratory epithelium and bronchial carcinomas: no evidence for altered CD44 splicing in metastasis by Givehchian, M, Woerner, S M, Lacroix, J, Zöller, M, Drings, P, Becker, H, Kayser, K, Ridder, R, von Knebel Doeberitz, M

“…Expression of alternatively spliced CD44 adhesion molecules has been implicated in metastatic spread of various rodent and human tumors. To determine whether…”
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Expression of CD44 splice variants in normal, dysplastic, and neoplastic cervical epithelium by Woerner, S M, Givehchian, M, Dürst, M, Schneider, A, Costa, S, Melsheimer, P, Lacroix, J, Zöller, M, Doeberitz, M K

“…Expression of splice variants of the CD44 adhesion molecule has been implicated in metastatic spread of various human tumor cells, including malignant…”
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