Search Results - "Woerner, Francis"

Control of Mechanical Stability of Hollow Silica Particles, and Its Measurement by Mercury Intrusion Porosimetry by Lasio, Jelena, Allgeier, Alan M, Chan, Christopher D, Londono, J. David, Najafi, Ebrahim, Woerner, Francis J

“…Hollow silica particles (HSPs) have become the focus of interest in many laboratories recently, because of their versatility, stemming from the ability to…”
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Phenyltriazolinones as potent factor Xa inhibitors by Quan, Mimi L., Pinto, Donald J.P., Rossi, Karen A., Sheriff, Steven, Alexander, Richard S., Amparo, Eugene, Kish, Kevin, Knabb, Robert M., Luettgen, Joseph M., Morin, Paul, Smallwood, Angela, Woerner, Francis J., Wexler, Ruth R.

“…We have discovered that phenyltriazolinone is a novel and potent P 1 moiety for coagulation factor Xa. X-ray structures of the inhibitors with a…”
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Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds by Smallheer, Joanne M., Weigelt, Carolyn A., Woerner, Francis J., Wells, Jennifer S., Daneker, Wayne F., Mousa, Shaker A., Wexler, Ruth R., Jadhav, Prabhakar K.

“…Analogues of isoxazoline α vβ 3 antagonist 1 designed to further restrict the four carbon alkyl tether were prepared by incorporating two spirocyclic…”
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Cyclic Urea Amides:  HIV-1 Protease Inhibitors with Low Nanomolar Potency against both Wild Type and Protease Inhibitor Resistant Mutants of HIV by Jadhav, Prabhakar K, Ala, Paul, Woerner, Francis J, Chang, Chong-Hwan, Garber, Sena S, Anton, Elizabeth D, Bacheler, Lee T

“…Cyclic urea amides, a novel series of HIV-1 protease (HIV PR) inhibitors, have increased activity against drug-resistant mutants of the HIV PR. The design…”
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Nonbenzamidine tetrazole derivatives as factor Xa inhibitors by Quan, Mimi L, Ellis, Christopher D, He, Ming Y, Liauw, Ann Y, Woerner, Francis J, Alexander, Richard S, Knabb, Robert M, Lam, Patrick Y.S, Luettgen, Joseph M, Wong, Pancras C, Wright, Matthew R, Wexler, Ruth R

“…Factor Xa (fXa) is an important serine protease that holds the central position linking the intrinsic and extrinsic activation mechanisms in the blood…”
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Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies by Jadhav, Prabhakar K, Woerner, Francis J, Lam, Patrick Y. S, Hodge, C. Nicholas, Eyermann, Charles J, Man, Hon-Wah, Daneker, Wayne F, Bacheler, Lee T, Rayner, Marlene M, Meek, James L, Erickson-Viitanen, Susan, Jackson, David A, Calabrese, Joseph C, Schadt, Margaret, Chang, Chong-Hwan

“…Comparison of the high-resolution X-ray structures of the native HIV-1 protease and its complexes with the inhibitors suggested that the enzyme flaps are…”
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Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors by Quan, Mimi L, Wong, Pancras C, Wang, Cailan, Woerner, Francis, Smallheer, Joanne M, Barbera, Frank A, Bozarth, Jeffrey M, Brown, Randi L, Harpel, Mark R, Luettgen, Joseph M, Morin, Paul E, Peterson, Tara, Ramamurthy, Vidhyashankar, Rendina, Alan R, Rossi, Karen A, Watson, Carol A, Wei, Anzhi, Zhang, Ge, Seiffert, Dietmar, Wexler, Ruth R

“…Antithrombotic agents that are inhibitors of factor XIa (FXIa) have the potential to demonstrate robust efficacy with a low bleeding risk profile. Herein, we…”
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Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties by Pinto, Donald J.P., Galemmo, Robert A., Quan, Mimi L., Orwat, Michael J., Clark, Charles, Li, Renhua, Wells, Brian, Woerner, Francis, Alexander, Richard S., Rossi, Karen A., Smallwood, Angela, Wong, Pancras C., Luettgen, Joseph M., Rendina, Alan R., Knabb, Robert M., He, Kan, Wexler, Ruth R., Lam, Patrick Y.S.

“…The bicyclic tetrahydropyrazolopiperidinone scaffold allowed for the incorporation of multiple neutral P1 moieties with subnanomolar binding affinities for…”
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Synthesis of 8-membered cyclic sulfamides: Novel HIV-1 protease inhibitors by Jadhav, Prabhakar K., Woerner, Francis J.

“…One pot synthesis of pseudo C2 symmetric (2S,6S)-2,6-dihydroxy-1,7-diphenylhept-4-one in high enantiomeric purity has been developed and the intermediate was…”
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Calculated and Experimental Low-Energy Conformations of Cyclic Urea HIV Protease Inhibitors by Hodge, C. Nicholas, Lam, Patrick Y. S, Eyermann, Charles J, Jadhav, Prabhakar K, Ru, Y, Fernandez, Christina H, De Lucca, George V, Chang, Chong-Hwan, Kaltenbach, Robert F, Holler, Edward R, Woerner, Francis, Daneker, Wayne F, Emmett, George, Calabrese, Joseph C, Aldrich, Paul E

“…One important factor influencing the affinity of a flexible ligand for a receptor is the internal strain energy required to attain the bound conformation…”
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Synthesis of 7-membered cyclic hydroxyguanidines: Novel HIV-1 protease inhibitors by Jadhav, Prabhakar K., Woerner, Francis J., Man, Hon-Wah

“…Novel cyclic 7-membered hydroxyguanidine based HIV-1 protease inhibitors have been synthesized from 7-membered cyclic thiourea. Graphic…”
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Synthesis of water soluble prodrug of DMP323 by Jadhav, Prabhakar K., Woerner, Francis J., Aungst, Bruce J.

“…A water soluble bisphosphate prodrug of DMP323 was synthesized from DMP323. Pharmacokinetic studies of the prodrug indicate that it is orally absorbed as the…”
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