Search Results - "Woermann, Sonja M."

Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma by Hosein, Abdel Nasser, Dangol, Gita, Okumura, Takashi, Roszik, Jason, Rajapakshe, Kimal, Siemann, Megan, Zaid, Mohamed, Ghosh, Bidyut, Monberg, Maria, Guerrero, Paola A., Singhi, Aatur, Haymaker, Cara L., Clevers, Hans, Abou-Elkacem, Lotfi, Woermann, Sonja M., Maitra, Anirban

“…RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The…”
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Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase by Ruess, Dietrich A., Heynen, Guus J., Ciecielski, Katrin J., Ai, Jiaoyu, Berninger, Alexandra, Kabacaoglu, Derya, Görgülü, Kivanc, Dantes, Zahra, Wörmann, Sonja M., Diakopoulos, Kalliope N., Karpathaki, Angeliki F., Kowalska, Marlena, Kaya-Aksoy, Ezgi, Song, Liang, van der Laan, Eveline A. Zeeuw, López-Alberca, María P., Nazaré, Marc, Reichert, Maximilian, Saur, Dieter, Erkan, Mert M., Hopt, Ulrich T., Sainz, Bruno, Birchmeier, Walter, Schmid, Roland M., Lesina, Marina, Algül, Hana

“…The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11 , is involved in signal transduction downstream of multiple growth…”
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Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival by Wörmann, Sonja M, Song, Liang, Ai, Jiaoyu, Diakopoulos, Kalliope N, Görgülü, Kivanc, Ruess, Dietrich, Campbell, Andrew, Doglioni, Claudio, Jodrell, Duncan, Neesse, Albrecht, Demir, Ekin I, Karpathaki, Angelica-Phaedra, Barenboim, Maxim, Hagemann, Thorsten, Rose-John, Stefan, Sansom, Owen, Schmid, Roland M, Protti, Maria P, Lesina, Marina, Algül, Hana

“…Background & Aims One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of…”
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Abstract PR-15: Identifying synergistic combinations with KRAS inhibition in PDAC by Thege, Fredrik I, Hoskins, Amber, Woermann, Sonja M, Maitra, Anirban

“…Abstract Background: To date, targeted therapies have largely failed in eliciting sustained responses in advanced pancreatic ductal adenocarcinoma (PDAC)…”
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Abstract C057: Delineating tissue-specific oncogene selection with autochthonous CRISPR activation screening by Thege, Fredrik I., Woermann, Sonja M., Maitra, Anirban

“…Abstract Background: While the genetic landscapes of pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC) are well described, the…”
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Abstract C55: Mapping the pharmacotranscriptomic landscape of pancreatic circulating tumor cell organoids by Thege, Fredrik I., Barathi, Bhargavi B., Rupani, Dhwani N., Woermann, Sonja M., Rhim, Andrew D.

“…Abstract Introduction: Pancreatic cancer is characterized by early metastasis and resistance to chemotherapy. To elucidate the transcriptional reprogramming…”
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Abstract 3: In vivo CRISPR activation screening identifies tissue-specific oncogene selection by Thege, Fredrik Ivar, Woermann, Sonja M., Maitra, Anirban

“…Abstract Background: While the genetic landscapes of pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC) are relatively well…”
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Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice by Görgülü, Kivanc, Diakopoulos, Kalliope N., Ai, Jiaoyu, Schoeps, Benjamin, Kabacaoglu, Derya, Karpathaki, Angeliki-Faidra, Ciecielski, Katrin J., Kaya-Aksoy, Ezgi, Ruess, Dietrich A., Berninger, Alexandra, Kowalska, Marlena, Stevanovic, Marija, Wörmann, Sonja M., Wartmann, Thomas, Zhao, Yue, Halangk, Walter, Voronina, Svetlana, Tepikin, Alexey, Schlitter, Anna Melissa, Steiger, Katja, Artati, Anna, Adamski, Jerzy, Aichler, Michaela, Walch, Axel, Jastroch, Martin, Hartleben, Götz, Mantzoros, Christos S., Weichert, Wilko, Schmid, Roland M., Herzig, Stephan, Krüger, Achim, Sainz, Bruno, Lesina, Marina, Algül, Hana

“…Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences…”
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Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes by Ai, Jiaoyu, Wörmann, Sonja M., Görgülü, Kıvanç, Vallespinos, Mireia, Zagorac, Sladjana, Alcala, Sonia, Wu, Nan, Kabacaoglu, Derya, Berninger, Alexandra, Navarro, Diego, Kaya-Aksoy, Ezgi, Ruess, Dietrich A., Ciecielski, Katrin J., Kowalska, Marlena, Demir, Ihsan Ekin, Ceyhan, Güralp O., Heid, Irina, Braren, Rickmer, Riemann, Marc, Schreiner, Sabrina, Hofmann, Samuel, Kutschke, Maria, Jastroch, Martin, Slotta-Huspenina, Julia, Muckenhuber, Alexander, Schlitter, Anna Melissa, Schmid, Roland M., Steiger, Katja, Diakopoulos, Kalliope N., Lesina, Marina, Sainz, Bruno, Algül, Hana

“…The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient…”
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Abstract C049: Loss of RNF43 creates an OXPHOS dependency in early pancreatic neoplasia by Sagara, Akiko, Chen, Brandon, Yee, Nathaniel G., Siemann, Megan J., Lyssiotis, Costas A., Shah, Yatrik M., Woermann, Sonja M., Maitra, Anirban

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) has a dismal 5-year survival of 12%. RNF43 is frequently mutated in pancreatic cystic neoplasms, including…”
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Abstract PR-18: RNF43 Loss Induces an IRE1-dependent Metabolic Reprogramming in Pancreatic Cystic Neoplasms by Sagara, Akiko, Lv, Xiangdong, Chen, Brandon, Makino, Yuki, So, Shui Ping, Woermann, Sonja M, Lyssiotis, Costas A, Shah, Yatrik M, Ghosh, Bidyut, Chen, Xi, Fahrmann, Johannes F, Maitra, Anirban

“…Abstract Background: RNF43 is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which are cystic precursor lesions of pancreatic ductal…”
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Pharmacotherapeutic Management of Pancreatic Ductal Adenocarcinoma: Current and Emerging Concepts by Ruess, Dietrich A., Görgülü, Kivanc, Wörmann, Sonja M., Algül, Hana

“…Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment…”
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