Search Results - "Woelbing, Florian"

Role and Mechanism of Galactose-Alpha-1,3-Galactose in the Elicitation of Delayed Anaphylactic Reactions to Red Meat by Hilger, Christiane, Fischer, Jörg, Wölbing, Florian, Biedermann, Tilo

“…Purpose of Review The alpha-Gal (α-Gal) syndrome is characterized by the presence of IgE antibodies directed at the carbohydrate galactose-alpha-1,3-galactose…”
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Cutaneous Innate Immune Sensing of Toll-like Receptor 2-6 Ligands Suppresses T Cell Immunity by Inducing Myeloid-Derived Suppressor Cells by Skabytska, Yuliya, Wölbing, Florian, Günther, Claudia, Köberle, Martin, Kaesler, Susanne, Chen, Ko-Ming, Guenova, Emmanuella, Demircioglu, Doruk, Kempf, Wolfgang E., Volz, Thomas, Rammensee, Hans-Georg, Schaller, Martin, Röcken, Martin, Götz, Friedrich, Biedermann, Tilo

“…Skin is constantly exposed to bacteria and antigens, and cutaneous innate immune sensing orchestrates adaptive immune responses. In its absence, skin pathogens…”
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ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression by Hoetzenecker, Wolfram, Echtenacher, Bernd, Guenova, Emmanuella, Hoetzenecker, Konrad, Woelbing, Florian, Brück, Jürgen, Teske, Anna, Valtcheva, Nadejda, Fuchs, Kerstin, Kneilling, Manfred, Park, Ji-Hyeon, Kim, Kyu-Han, Kim, Kyu-Won, Hoffmann, Petra, Krenn, Claus, Hai, Tsonwin, Ghoreschi, Kamran, Biedermann, Tilo, Röcken, Martin

“…Sepsis is associated with a hyperinduction of proinflammatory cytokines. ATF3, a transcription factor, is induced in macrophages under conditions of endotoxic…”
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The History of Carbohydrates in Type I Allergy by Hils, Miriam, Wölbing, Florian, Hilger, Christiane, Fischer, Jörg, Hoffard, Nils, Biedermann, Tilo

“…Although first described decades ago, the relevance of carbohydrate specific antibodies as mediators of type I allergy had not been recognized until recently…”
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Gene-edited pigs: a translational model for human food allergy against alpha-Gal and anaphylaxis by Wang, Ying, Hils, Miriam, Fischer, Andrea, Wölbing, Florian, Biedermann, Tilo, Schnieke, Angelika, Fischer, Konrad

“…The prevalence of food allergy is rising and is estimated to approach 10%. Red meat allergy is the first known food allergy elicited by immunoglobulin E (IgE)…”
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Toll-like receptor 2 ligands promote chronic atopic dermatitis through IL-4–mediated suppression of IL-10 by Kaesler, Susanne, PhD, Volz, Thomas, MD, Skabytska, Yuliya, MSc, Köberle, Martin, PhD, Hein, Ulrike, MD, Chen, Ko-Ming, MD, Guenova, Emmanuella, MD, Wölbing, Florian, MD, Röcken, Martin, MD, Biedermann, Tilo, MD

“…Background Atopic dermatitis (AD) is a T cell–mediated inflammatory skin disease, with TH 2 cells initiating acute flares. This inflamed skin is immediately…”
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CD13/aminopeptidase N is a negative regulator of mast cell activation by Zotz, Julia S., Wölbing, Florian, Lassnig, Caroline, Kauffmann, Marlies, Schulte, Uwe, Kolb, Andreas, Whitelaw, Bruce, Müller, Mathias, Biedermann, Tilo, Huber, Michael

“…ABSTRACT Antigen‐induced mast cell (MC) activation via cross‐linking of IgE‐bound high‐affinity receptors for IgE (FcεRI) underlies type I allergy and…”
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Targeting tumor-resident mast cells for effective anti-melanoma immune responses by Kaesler, Susanne, Wölbing, Florian, Kempf, Wolfgang Eberhard, Skabytska, Yuliya, Köberle, Martin, Volz, Thomas, Sinnberg, Tobias, Amaral, Teresa, Möckel, Sigrid, Yazdi, Amir, Metzler, Gisela, Schaller, Martin, Hartmann, Karin, Weide, Benjamin, Garbe, Claus, Rammensee, Hans-Georg, Röcken, Martin, Biedermann, Tilo

“…Immune checkpoint blockade has revolutionized cancer treatment. Patients developing immune mediated adverse events, such as colitis, appear to particularly…”
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Uptake of Leishmania major by dendritic cells is mediated by Fcγ receptors and facilitates acquisition of protective immunity by Woelbing, Florian, Kostka, Susanna Lopez, Moelle, Katharina, Belkaid, Yasmine, Sunderkoetter, Cord, Verbeek, Sjef, Waisman, Ari, Nigg, Axel P., Knop, Juergen, Udey, Mark C., von Stebut, Esther

“…Uptake of Leishmania major by dendritic cells (DCs) results in activation and interleukin (IL)-12 release. Infected DCs efficiently stimulate CD4− and CD8− T…”
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Staphylococcus aureus –derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2 by Kaesler, Susanne, PhD, Skabytska, Yuliya, PhD, Chen, Ko-Ming, MD, DSc, Kempf, Wolfgang E., MSc, Volz, Thomas, MD, Köberle, Martin, PhD, Wölbing, Florian, MD, Hein, Ulrike, MD, Hartung, Thomas, MD, PhD, Kirschning, Carsten, PhD, Röcken, Martin, MD, Biedermann, Tilo, MD

“…Background The interplay between microbes and surface organs, such as the skin, shapes a complex immune system with several checks and balances. The first-line…”
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Fetal Tissue-Derived Mast Cells (MC) as Experimental Surrogate for In Vivo Connective Tissue MC by Iuliano, Caterina, Absmaier-Kijak, Magdalena, Sinnberg, Tobias, Hoffard, Nils, Hils, Miriam, Köberle, Martin, Wölbing, Florian, Shumilina, Ekaterina, Heise, Nicole, Fehrenbacher, Birgit, Schaller, Martin, Lang, Florian, Kaesler, Susanne, Biedermann, Tilo

“…Bone-marrow-derived mast cells are matured from bone marrow cells in medium containing 20% fetal calf serum (FCS), interleukin (IL)-3 and stem-cell factor…”
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Augmentation to Anaphylaxis: The Role of Aspirin and Physical Exercise as Co-factors by Wölbing, F, Biedermann, T

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IL-4-mediated fine tuning of IL-12p70 production by human DC by Guenova, Emmanuella, Volz, Thomas, Sauer, Karin, Kaesler, Susanne, Müller, Martin R, Wölbing, Florian, Chen, KoMing, Schwärzler, Christoph, Brossart, Peter, Röcken, Martin, Biedermann, Tilo

“…IL-4 is expressed at high levels in allergic diseases and dominates the early phases of multiple acquired immune responses. However, the precise role of IL-4…”
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Tetraspanins in mast cells by Köberle, Martin, Kaesler, Susanne, Kempf, Wolfgang, Wölbing, Florian, Biedermann, Tilo

“…Mast cells (MC) are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator…”
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Dermal Interleukin-1 Expression and Effective and Long-lasting Therapy with Interleukin-1 Receptor Antagonist Anakinra in Schnitzler Syndrome by VOLZ, Thomas, WÖLBING, Florian, FISCHER, Jörg, BRAUN, Martin, MAGGOSCHITZ, Iryna, SCHALLER, Martin, BERNEBURG, Mark, BIEDERMANN, Tilo

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Impaired Mast Cell Activation in Gene-Targeted Mice Lacking the Serum- and Glucocorticoid-Inducible Kinase SGK1 by Sobiesiak, Malgorzata, Shumilina, Ekaterina, Lam, Rebecca S, Wolbing, Florian, Matzner, Nicole, Kaesler, Susanne, Zemtsova, Irina M, Lupescu, Adrian, Zahir, Naima, Kuhl, Dietmar, Schaller, Martin, Biedermann, Tilo, Lang, Florian

“…The PI3K pathway plays a pivotal role in the stimulation of mast cells. PI3K-dependent kinases include the serum- and glucocorticoid-inducible kinase 1 (SGK1)…”
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Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine by Guenova, Emmanuella, Lichte, Verena, Hoetzenecker, Wolfram, Woelbing, Florian, Moehrle, Matthias, Roecken, Martin, Schaller, Martin

“…Immunosuppressed patients are at increased risk of skin cancer. A 67-year-old renal transplant recipient developed a nodular malignant melanoma after 30 years…”
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Dendritic Cell-Derived IL-12p40 Homodimer Contributes to Susceptibility in Cutaneous Leishmaniasis in BALB/c Mice by Nigg, Axel P, Zahn, Sabine, Ruckerl, Dominik, Holscher, Christoph, Yoshimoto, Takayuki, Ehrchen, Jan M, Wolbing, Florian, Udey, Mark C, von Stebut, Esther

“…Protection against Leishmania major in resistant C57BL/6 mice is mediated by Th1 cells, whereas susceptibility in BALB/c mice is the result of Th2 development…”
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Septic shock after treatment of pyoderma gangrenosum with infliximab by Wölbing, Florian, Fierlbeck, Gerhard, Hötzenecker, Wolfram, Schaller, Martin, Röcken, Martin

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Blunted IgE-Mediated Activation of Mast Cells in Mice Lacking the Ca super(2+)-Activated K super(+) Channel K sub(Ca)3.1 by Shumilina, Ekaterina, Lam, Rebecca S, Woelbing, Florian, Matzner, Nicole, Zemtsova, Irina M, Sobiesiak, Malgorzata, Mahmud, Hasan, Sausbier, Ulrike, Biedermann, Tilo, Ruth, Peter, Sausbier, Matthias, Lang, Florian

“…Mast cell stimulation by Ag is followed by the opening of Ca super(2+)-activated K super(+) channels, which participate in the orchestration of mast cell…”
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