Search Results - "Wołkow, Paweł"
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Fibrin Clot Permeability as a Predictor of Stroke and Bleeding in Anticoagulated Patients With Atrial Fibrillation
Published in Stroke (1970) (01-10-2017)“…BACKGROUND AND PURPOSE—Formation of denser fiber networks has been reported in atrial fibrillation and ischemic stroke. In this longitudinal cohort study, we…”
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Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn’s disease
Published in Scientific reports (11-12-2019)“…The aetiology of inflammatory bowel diseases (IBD) seems to be strongly connected to changes in the enteral microbiome. The dysbiosis pattern seen in Crohn’s…”
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Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: Association with thrombin generation, endothelial injury and platelet activation
Published in Thrombosis research (01-08-2015)“…Abstract Introduction Formation of compact and poorly lysable fibrin clots have been demonstrated in patients following ischemic stroke. Recently, it has been…”
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In vitro maturation of monocyte-derived dendritic cells results in two populations of cells with different surface marker expression, independently of applied concentration of interleukin-4
Published in International immunopharmacology (01-04-2018)“…Dendritic cells (DCs) play a crucial role in the development of adaptive immune response. Monocyte-derived dendritic cells (MDDCs) are generated in vitro to…”
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Patterns of gene expression characterize T1 and T3 clear cell renal cell carcinoma subtypes
Published in PloS one (31-05-2019)“…Renal carcinoma is the 20th most common cancer worldwide. Clear cell renal cell carcinoma is the most frequent type of renal cancer. Even in patients diagnosed…”
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Intratumor heterogeneity in colorectal cancer: Distribution of tumor suppressor gene variants with regard to patient lymph node status
Published in Clinical genetics (01-10-2023)“…Intratumor heterogeneity (ITH) results from accumulation of somatic mutations in the fractions of successive cancer cell generations. We aimed to use deep…”
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Intensive low-density lipoprotein cholesterol lowering improves fibrin clot properties: Association with lipoproteins and C-reactive protein
Published in Vascular pharmacology (01-06-2022)“…Dense fibrin networks resistant to lysis characterize coronary artery disease (CAD) patients. We investigated whether a statin-induced decrease of low-density…”
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MicroRNA composition of plasma extracellular vesicles: a harbinger of late cardiotoxicity of doxorubicin
Published in Molecular medicine (Cambridge, Mass.) (14-12-2022)“…The use of doxorubicin is associated with an increased risk of acute and long-term cardiomyopathy. Despite the constantly growing number of cancer survivors,…”
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Characteristics of gut microbiota in adult patients with type 1 and type 2 diabetes based on next‑generation sequencing of the 16S rRNA gene fragment
Published in Polskie archiwum medycyny wewne̦trznej (30-06-2018)“…Introduction Scientific data indicate a possible influence of gut microbiota on the development of type 1 and type 2 diabetes mellitus (T1DM and T2DM,…”
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Cytosolic nucleic acid sensing and mitochondrial transcriptomic changes as early triggers of metabolic disease in db/db mice
Published in Mammalian genome (01-03-2024)“…Animal models of diabetes, such as db/db mice, are a useful tool for deciphering the genetic background of molecular changes at the initial stages of disease…”
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Dysregulation of Transcription Factor Activity During Formation of Cancer-Associated Fibroblasts
Published in International journal of molecular sciences (19-11-2020)“…The reciprocal interactions between cancer cells and the quiescent fibroblasts leading to the activation of cancer-associated fibroblasts (CAFs) serve an…”
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Expression of VEGFA-mRNA in classical and MSX2-mRNA in non-classical monocytes in patients with spondyloarthritis is associated with peripheral arthritis
Published in Scientific reports (06-05-2021)“…Spondyloarthritis (SpA) is characterized by chronic inflammation and structural damage involving spine and peripheral joints. Monocytes, as part of innate…”
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Variants influencing age at diagnosis of HNF1A-MODY
Published in Molecular medicine (Cambridge, Mass.) (14-09-2022)“…HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease…”
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Synthesis of Nonsymmetrically Substituted 2,3-Dialkoxyphenazine Derivatives and Preliminary Examination of Their Cytotoxicity
Published in Journal of organic chemistry (03-02-2023)“…Fourteen new 2,3-dialkoxyphenazine derivatives with two different alkoxy groups bearing R1 and R2 alkyl chains, defined as −CH2CH(CH3)2 and −(CH2) n−1CH3 for…”
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Negative pressure wound therapy affects circulating plasma microRNAs in patients with diabetic foot ulceration
Published in Diabetes research and clinical practice (01-07-2020)“…Negative pressure wound therapy (NPWT) is commonly used in diabetic foot ulceration (DFU). The molecular mechanisms of NPWT action, particularly outside of the…”
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The transcriptome-wide association search for genes and genetic variants which associate with BMI and gestational weight gain in women with type 1 diabetes
Published in Molecular medicine (Cambridge, Mass.) (20-01-2021)“…Clinical data suggest that BMI and gestational weight gain (GWG) are strongly interconnected phenotypes; however, the genetic basis of the latter is rather…”
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Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis
Published in Clinical biochemistry (01-07-2022)“…•The role of paraoxonase gene polymorphisms (SNPs) in coronary artery disease (CAD) is unclear.•We searched for a link between paraoxonase SNPs and the type of…”
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Therapeutic role of eicosapentaenoic and arachidonic acid in benzo(a) pyrene-induced toxicity in HUVEC endothelial cells
Published in Life sciences (1973) (15-03-2022)“…Endothelial cells are characterized by intense metabolic activity and control of homeostasis. Exposure to benzo(a)pyrene (BaP) plays an important role in the…”
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Epigenetic mechanism in search for the pathomechanism of diabetic neuropathy development in diabetes mellitus type 1 (T1DM)
Published in Endocrine (01-04-2020)“…Objective The aim of this study was to check the hypothesis concerning the crucial role of DNA methylation (one of the epigenetic mechanisms) within selected…”
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Methylation and Expression of FTO and PLAG1 Genes in Childhood Obesity: Insight into Anthropometric Parameters and Glucose-Lipid Metabolism
Published in Nutrients (15-05-2021)“…The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. ( alpha-ketoglutarate dependent dioxygenase) is a gene of…”
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