Search Results - "Wlodarczyk, Bogdan J"

Gene Environment Interactions in the Etiology of Neural Tube Defects by Finnell, Richard H, Caiaffa, Carlo Donato, Kim, Sung-Eun, Lei, Yunping, Steele, John, Cao, Xuanye, Tukeman, Gabriel, Lin, Ying Linda, Cabrera, Robert M, Wlodarczyk, Bogdan J

“…Human structural congenital malformations are the leading cause of infant mortality in the United States. Estimates from the United States Center for Disease…”
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Antiepileptic drugs and pregnancy outcomes by Wlodarczyk, Bogdan J., Palacios, Ana M., George, Timothy M., Finnell, Richard H.

“…The treatment of epilepsy in women of reproductive age remains a clinical challenge. While most women with epilepsy (WWE) require anticonvulsant drugs for…”
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The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development by Wallingford, John B, Finnell, Richard H, Gray, Ryan S, Abitua, Philip B, Wlodarczyk, Bogdan J, Szabo-Rogers, Heather L, Blanchard, Otis, Lee, Insuk, Weiss, Greg S, Liu, Karen J, Marcotte, Edward M

“…The planar cell polarity (PCP) signalling pathway is essential for embryonic development because it governs diverse cellular behaviours, and 'core PCP'…”
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Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development by Kim, Sung-Eun, Robles-Lopez, Karla, Cao, Xuanye, Liu, Kristyn, Chothani, Pooja J, Bhavani, Nikitha, Rahman, Lauren, Mukhopadhyay, Saikat, Wlodarczyk, Bogdan J, Finnell, Richard H

“…Sonic hedgehog (Shh) signaling regulates multiple morphogenetic processes during embryonic neurogenesis and craniofacial skeletal development. Gpr161 is a…”
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Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice by Wlodarczyk, Bogdan J, Ogle, Krystal, Lin, Linda Ying, Bialer, Meir, Finnell, Richard H

“…Objectives Based on the recent findings from animal studies, it has been proposed that the therapeutic use of valnoctamide, an anxiolytic drug developed in the…”
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Excess folic acid intake increases DNA de novo point mutations by Cao, Xuanye, Xu, Jianfeng, Lin, Ying L., Cabrera, Robert M., Chen, Qiuying, Zhang, Chaofan, Steele, John W., Han, Xiao, Gross, Steven S., Wlodarczyk, Bogdan J., Lupski, James R., Li, Wei, Wang, Hongyan, Finnell, Richard H., Lei, Yunping

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Fuz regulates craniofacial development through tissue specific responses to signaling factors by Zhang, Zichao, Wlodarczyk, Bogdan J, Niederreither, Karen, Venugopalan, Shankar, Florez, Sergio, Finnell, Richard H, Amendt, Brad A

“…The planar cell polarity effector gene Fuz regulates ciliogenesis and Fuz loss of function studies reveal an array of embryonic phenotypes. However, cilia…”
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Autism-Like Behavior and Epigenetic Changes Associated with Autism as Consequences of In Utero Exposure to Environmental Pollutants in a Mouse Model by Wlodarczyk, Bogdan J., Lu, Wei, Zhu, Huiping, Wallis Schultz, Deeann, Cabrera, Robert, Hill, Denise S., Finnell, Richard H.

“…We tested the hypothesis that in utero exposure to heavy metals increases autism-like behavioral phenotypes in adult animals and induces epigenetic changes in…”
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Somatic and de novo Germline Variants of MEDs in Human Neural Tube Defects by Tian, Tian, Cao, Xuanye, Chen, Yongyan, Jin, Lei, Li, Zhiwen, Han, Xiao, Lin, Ying, Wlodarczyk, Bogdan J, Finnell, Richard H, Yuan, Zhengwei, Wang, Linlin, Ren, Aiguo, Lei, Yunping

“…Neural tube defects (NTDs) are among the most common and severe congenital defects in humans. Their genetic etiology is complex and remains poorly understood…”
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Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects by Steele, John W, Lin, Ying Linda, Chen, Nellie, Wlodarczyk, Bogdan J, Chen, Qiuying, Attarwala, Nabeel, Venkatesalu, Madhu, Cabrera, Robert M, Gross, Steven S, Finnell, Richard H

“…Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological…”
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Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model by Hill, Denise S., Wlodarczyk, Bogdan J., Finnell, Richard H.

“…BACKGROUND: The second most common of all structural birth defects, neural tube defects (NTDs), affect approximately 2.6/1,000 births worldwide, and 1/1,000…”
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Linkage between Fuz and Gpr161 genes regulates sonic hedgehog signaling during mouse neural tube development by Kim, Sung-Eun, Kim, Hyun-Yi, Wlodarczyk, Bogdan J, Finnell, Richard H

“…Sonic hedgehog (Shh) signaling regulates embryonic morphogenesis utilizing the primary cilium, the cell's antenna, which acts as a signaling hub. Fuz, an…”
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Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube by Wong, Rebecca Lee Yean, Wlodarczyk, Bogdan J., Min, Kyung Soo, Scott, Melissa L., Kartiko, Susan, Yu, Wei, Merriweather, Michelle Y., Vogel, Peter, Zambrowicz, Brian P., Finnell, Richard H.

“…Neural tube defects (NTDs) are birth defects that can be disabling or lethal and are second in their prevalence after cardiac defects among major human…”
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Genetic basis of susceptibility to teratogen induced birth defects by Wlodarczyk, Bogdan J., Palacios, Ana M., Chapa, Claudia J., Zhu, Huiping, George, Timothy M., Finnell, Richard H.

“…Birth defects remain the leading cause of infant death in US. The field of teratology has been focused on the causes and underlying mechanisms of birth defects…”
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Dolutegravir induced neural tube defects in mice are folate responsive by Tukeman, Gabriel L., Wei, Hui, Finnell, Richard H., Cabrera, Robert M.

“…In 2018, the Botswana Tsepamo Study reported a nine-fold increased risk of neural tube defects in infants whose mothers were treated with dolutegravir (DTG)…”
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Folate regulation of planar cell polarity pathway and F‐actin through folate receptor alpha by Han, Xiao, Cao, Xuanye, Cabrera, Robert M., Ramirez, Paula Andrea Pimienta, Lin, Ying Linda, Wlodarczyk, Bogdan J., Zhang, Cuilian, Finnell, Richard H., Lei, Yunping

“…Folate deficiency contribute to neural tube defects (NTDs) which could be rescued by folate supplementation. However, the underlying mechanisms are still not…”
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Cardiovascular abnormalities in Folr1 knockout mice and folate rescue by Zhu, Huiping, Wlodarczyk, Bogdan J., Scott, Melissa, Yu, Wei, Merriweather, Michelle, Gelineau-van Waes, Janee, Schwartz, Robert J., Finnell, Richard H.

“…BACKGROUND: Periconceptional folic acid supplementation is widely believed to aid in the prevention of neural tube defects (NTDs), orofacial clefts, and…”
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Formate rescues neural tube defects caused by mutations in Slc25a32 by Kim, Jimi, Lei, Yunping, Guo, Jin, Kim, Sung-Eun, Wlodarczyk, Bogdan J., Cabrera, Robert M., Lin, Ying Linda, Nilsson, Torbjorn K., Zhang, Ting, Ren, Aiguo, Wang, Linlin, Yuan, Zhengwei, Zheng, Yu-Fang, Wang, Hong-Yan, Finnell, Richard H.

“…Periconceptional folic acid (FA) supplementation significantly reduces the prevalence of neural tube defects (NTDs). Unfortunately, some NTDs are FA resistant,…”
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Dominant negative GPR161 rare variants are risk factors of human spina bifida by Kim, Sung-Eun, Lei, Yunping, Hwang, Sun-Hee, Wlodarczyk, Bogdan J, Mukhopadhyay, Saikat, Shaw, Gary M, Ross, M Elizabeth, Finnell, Richard H

“…Abstract Spina bifida (SB) is a complex disorder of failed neural tube closure during the first month of human gestation, with a suspected etiology involving…”
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Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the Mthfd1l murine mutant by Ambekar, Yogeshwari S, Caiaffa, Carlo Donato, Wlodarczyk, Bogdan J, Singh, Manmohan, Schill, Alexander W, Steele, John W, Zhang, Jitao, Aglyamov, Salavat R, Scarcelli, Giuliano, Finnell, Richard H, Larin, Kirill V

“…Neurulation is a highly synchronized biomechanical process leading to the formation of the brain and spinal cord, and its failure leads to neural tube defects…”
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