Search Results - "Wiwie, Christian"
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Un-biased housekeeping gene panel selection for high-validity gene expression analysis
Published in Scientific reports (19-07-2022)“…Differential gene expression normalised to a single housekeeping (HK) is used to identify disease mechanisms and therapeutic targets. HK gene selection is…”
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Comparing the performance of biomedical clustering methods
Published in Nature methods (01-11-2015)“…This analysis compares 13 clustering methods on 24 data sets using the freely accessible ClustEval platform and presents guidelines for how to choose tools and…”
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Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
Published in Nature genetics (01-04-2019)“…Mesenchymal (stromal) stem cells (MSCs) constitute populations of mesodermal multipotent cells involved in tissue regeneration and homeostasis in many…”
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Guiding biomedical clustering with ClustEval
Published in Nature protocols (01-06-2018)“…Clustering is an important first step in discovering groups of similar objects in large datasets. ClustEval can be used to find data clusters using multiple…”
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ON THE POWER AND LIMITS OF SEQUENCE SIMILARITY BASED CLUSTERING OF PROTEINS INTO FAMILIES
Published in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing (2017)“…Over the last decades, we have observed an ongoing tremendous growth of available sequencing data fueled by the advancements in wet-lab technology. The…”
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Massive fungal biodiversity data re-annotation with multi-level clustering
Published in Scientific reports (30-10-2014)“…With the availability of newer and cheaper sequencing methods, genomic data are being generated at an increasingly fast pace. In spite of the high degree of…”
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Author Correction: Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
Published in Nature genetics (01-04-2019)“…In the version of this article initially published, in the graph keys in Fig. 1i, the colors indicating ‘Ob’ and ‘Ad’ were red and blue, respectively, but…”
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TiCoNE 2: A Composite Clustering Model for Robust Cluster Analyses on Noisy Data
Published 28-04-2019“…Identifying groups of similar objects using clustering approaches is one of the most frequently employed first steps in exploratory biomedical data analysis…”
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Elucidation of time-dependent systems biology cell response patterns with time course network enrichment
Published 27-10-2017“…Advances in OMICS technologies emerged both massive expression data sets and huge networks modelling the molecular interplay of genes, RNAs, proteins and…”
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