Search Results - "Wittorf, Karli J."

Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases by Hynes-Smith, R. Willow, Wittorf, Karli J., Buckley, Shannon M.

“…Hematopoiesis is responsible for numerous functions, ranging from oxygen transportation to host defense, to injury repair. This process of hematopoiesis is…”
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Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis by Wittorf, Karli J., Weber, Kasidy K., Swenson, Samantha A., Buckley, Shannon M.

“…•In vitro knockdown of FBXO21 alters HSPC maintenance and differentiation.•Steady-state hematopoiesis is minimally altered following deletion Fbxo21 in…”
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The Role of Ubiquitin E3 Ligase, FBOX21, in Regulating Healthy and Malignant Hematopoietic Stem and Progenitor Cells (HSPC) by Wittorf, Karli J., Weber, Kasidy K., Swenson, Samantha A., Buckley, Shannon M.

“…Hematopoietic stem cells allow for the formation of all cell types in the blood and maintain these populations throughout a person’s life. Hematopoietic cell…”
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Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML by Caplan, Mika, Wittorf, Karli J., Weber, Kasidy K., Swenson, Samantha A., Gilbreath, Tyler J., Willow Hynes-Smith, R., Amador, Catalina, Hyde, R. Katherine, Buckley, Shannon M.

“…Acute myeloid leukemia (AML) is a devastating cancer affecting the hematopoietic system. Previous research has relied on RNA sequencing and microarray…”
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Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation by Swenson, Samantha A, Dobish, Kasidy K, Peters, Hendrik C, Bea Winship, C, Willow Hynes-Smith, R, Caplan, Mika, Wittorf, Karli J, Ghosal, Gargi, Buckley, Shannon M

“…Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have unique characteristics where they can both contribute to all three germ layers in…”
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FBXO21 mediated degradation of p85α regulates proliferation and survival of acute myeloid leukemia by Dobish, Kasidy K., Wittorf, Karli J., Swenson, Samantha A., Bean, Dalton C., Gavile, Catherine M., Woods, Nicholas T., Ghosal, Gargi, Hyde, R. Katherine, Buckley, Shannon M.

“…Acute myeloid leukemia (AML) is a heterogeneous disease characterized by clonal expansion of myeloid blasts in the bone marrow (BM). Despite advances in…”
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Loss of FBXO9 Enhances Proteasome Activity and Promotes Aggressiveness in Acute Myeloid Leukemia by Hynes-Smith, R Willow, Swenson, Samantha A, Vahle, Heather, Wittorf, Karli J, Caplan, Mika, Amador, Catalina, Hyde, R Katherine, Buckley, Shannon M

“…The hematopoietic system is maintained throughout life by stem cells that are capable of differentiating into all hematopoietic lineages. An intimate balance…”
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