Search Results - "Wittkopf, Nadine"

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing by Pickert, Geethanjali, Neufert, Clemens, Leppkes, Moritz, Zheng, Yan, Wittkopf, Nadine, Warntjen, Moritz, Lehr, Hans-Anton, Hirth, Sebastian, Weigmann, Benno, Wirtz, Stefan, Ouyang, Wenjun, Neurath, Markus F, Becker, Christoph

“…Signal transducer and activator of transcription (STAT) 3 is a pleiotropic transcription factor with important functions in cytokine signaling in a variety of…”
Get full text

Immune-epithelial crosstalk at the intestinal surface by Wittkopf, Nadine, Neurath, Markus F., Becker, Christoph

“…The intestinal tract is one of the most complex organs of the human body. It has to exercise various functions including food and water absorption, as well as…”
Get full text

Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection by Wittkopf, Nadine, Pickert, Geethanjali, Billmeier, Ulrike, Mahapatro, Mousumi, Wirtz, Stefan, Martini, Eva, Leppkes, Moritz, Neurath, Markus Friedrich, Becker, Christoph

“…Gastrointestinal infections with EHEC and EPEC are responsible for outbreaks of diarrheal diseases and represent a global health problem. Innate…”
Get full text

STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis by Backert, Ingo, Koralov, Sergei B, Wirtz, Stefan, Kitowski, Vera, Billmeier, Ulrike, Martini, Eva, Hofmann, Katharina, Hildner, Kai, Wittkopf, Nadine, Brecht, Katrin, Waldner, Maximilian, Rajewsky, Klaus, Neurath, Markus F, Becker, Christoph, Neufert, Clemens

“…The Citrobacter rodentium model mimics the pathogenesis of infectious colitis and requires sequential contributions from different immune cell populations,…”
Get full text

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8 by Wittkopf, Nadine, Günther, Claudia, Martini, Eva, He, Guiwei, Amann, Kerstin, He, You–Wen, Schuchmann, Marcus, Neurath, Markus F, Becker, Christoph

“…Background & Aims The intestinal epithelium generates a barrier that protects mammals from potentially harmful intestinal contents, such as pathogenic…”
Get full text

Activation of epithelial STAT3 regulates intestinal homeostasis by Neufert, Clemens, Pickert, Geethanjali, Zheng, Yan, Wittkopf, Nadine, Warntjen, Moritz, Nikolae, Alexei, Ouyang, Wenjun, Neurath, Markus F., Becker, Christoph

“…The intestinal epithelium that lines the mucosal surface along the GI-tract is a key player for the intestinal homeostasis of the healthy individual. In case…”
Get full text

Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis by Martini, Eva, Wittkopf, Nadine, Günther, Claudia, Leppkes, Moritz, Okada, Hitoshi, Watson, Alastair J., Podstawa, Eva, Backert, Ingo, Amann, Kerstin, Neurath, Markus F., Becker, Christoph

“…A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. Survivin is…”
Get full text

Confocal laser endomicroscopy for in vivo diagnosis of Clostridium difficile associated colitis - a pilot study by Neumann, Helmut, Günther, Claudia, Vieth, Michael, Grauer, Martin, Wittkopf, Nadine, Mudter, Jonas, Becker, Christoph, Schoerner, Christoph, Atreya, Raja, Neurath, Markus F

“…Clostridium difficile infection (CDI) is one of the most dreaded causes of hospital-acquired diarrhea. Main objective was to investigate whether confocal laser…”
Get full text

Potential Stem Cell Marker CD44 is Constitutively Expressed in Permanent Cell Lines of Head and Neck Cancer by Pries, Ralph, Witrkopf, Nadine, Trenkle, Thomas, Nitsch, Stefan M, Wollenberg, Barbara

“…Background: Despite significant advances in the use of diagnosis and therapy to treat head and neck squamous cell carcinoma (HNSCC), the prognosis has improved…”
Get full text

Expression of the T cell receptor αβ on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma by Thiel, Annette, Kesselring, Rebecca, Pries, Ralph, Puzik, Alexander, Wittkopf, Nadine, Wollenberg, Barbara

“…Human Plasmacytoid Dendritic Cells (PDCs) infiltrating solid tumor tissues and draining lymph nodes of Head and Neck Squamous Cell Carcinoma (HNSCC) show an…”
Get full text

Advanced endoscopic imaging: from the top of the fold to the single bacterium by Neumann, Helmut, MD, PhD, Wittkopf, Nadine, MS, Atreya, Raja, MD, PhD, Becker, Christoph, PhD, Vieth, Michael, MD, PhD, Neurath, Markus F., MD, PhD

Get full text

Decreased Migration of Myeloid Dendritic Cells through Increased Levels of C-Reactive Protein by FRENZEL, Henning, PRIES, Ralph, BROCKS, Carsten P, JABS, Wolfram J, WITTKOPF, Nadine, WOLLENBERG, Barbara

“…Background: In head and neck squamous cell carcinoma (HNSCC), a variety of immunomodulatory mediators contribute to strongly impaired immune functions. The…”
Get full text

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis by Günther, Claudia, Martini, Eva, Wittkopf, Nadine, Amann, Kerstin, Weigmann, Benno, Neumann, Helmut, Waldner, Maximilian J., Hedrick, Stephen M., Tenzer, Stefan, Neurath, Markus F., Becker, Christoph

“…Epithelial cell death in intestinal inflammatory disease Two groups identify the regulation of death-receptor-induced necroptosis as an epithelial intrinsic…”
Get full text

Caspase-8 controls the gut response to microbial challenges by Tnf-α-dependent and independent pathways by Günther, Claudia, Buchen, Barbara, He, Gui-Wei, Hornef, Mathias, Torow, Natalia, Neumann, Helmut, Wittkopf, Nadine, Martini, Eva, Basic, Marijana, Bleich, André, Watson, Alastair J M, Neurath, Markus F, Becker, Christoph

“…Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient…”
Get more information

β-(1→3)-D-glucan modulates DNA binding of nuclear factors κB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1β/IL-1 receptor antagonist ratio by Luhm, Juergen, Langenkamp, Ulrich, Hensel, Jenny, Frohn, Christoph, Brand, Joerg M, Hennig, Holger, Rink, Lothar, Koritke, Petra, Wittkopf, Nadine, Williams, David L, Mueller, Antje

“…Abstract Background β-1→3-D-glucans represent a pathogen-associated molecular pattern and are able to modify biological responses. Employing a comprehensive…”
Get full text

VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis by Foersch, Sebastian, Sperka, Tobias, Lindner, Christina, Taut, Astrid, Rudolph, Karl L, Breier, Georg, Boxberger, Frank, Rau, Tilman T, Hartmann, Arndt, Stürzl, Michael, Wittkopf, Nadine, Haep, Lisa, Wirtz, Stefan, Neurath, Markus F, Waldner, Maximilian J

“…Background & Aims Senescence prevents cellular transformation. We investigated whether vascular endothelial growth factor (VEGF) signaling via its receptor,…”
Get full text

Lack of Intestinal Epithelial Atg7 Affects Paneth Cell Granule Formation but Does Not Compromise Immune Homeostasis in the Gut by Günther, Claudia, Waldner, Maximilian J., Wittkopf, Nadine, Becker, Christoph, Neurath, Markus F., Amann, Kerstin U., Martini, Eva

“…Genetic polymorphisms of autophagy-related genes have been associated with an increased risk to develop inflammatory bowel disease (IBD). Autophagy is an…”
Get full text

403 Survivin Deletion Drives Mitotic Catastrophe in Intestinal Epithelial Cells by Martini, Eva, Wittkopf, Nadine, Günther, Claudia, Okada, Hitoshi, Neurath, Markus F, Becker, Christoph

Get full text

Tu1731 Survivin Controls the Homeostasis of the Intestinal Stem Cell Niche by Martini, Eva, Wittkopf, Nadine, Günther, Claudia, Okada, Hitoshi, Neurath, Markus FF, Becker, Christoph

Get full text

Su1868 Constant Stimulation of Epithelial Cell Death in the Steady-State Gut Is Controlled via CFLIP by Wittkopf, Nadine, Günther, Claudia, Martini, Eva, He, You-Wen, Schuchmann, Marcus, Neurath, Markus F, Becker, Christoph

Get full text